KEGG   ENZYME: 2.3.1.78Help
Entry
EC 2.3.1.78                 Enzyme                                 
Name heparan-alpha-glucosaminide N-acetyltransferase;
acetyl-CoA:alpha-glucosaminide N-acetyltransferase
Class Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase
Reaction(IUBMB) acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan
sulfate N-acetyl-alpha-D-glucosaminide [RN:R04466 R07815]
Reaction(KEGG) R04466 R07815(G)
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Substrate acetyl-CoA [CPD:C00024];
heparan sulfate alpha-D-glucosaminide [CPD:C04384]
Product CoA [CPD:C00010];
heparan sulfate N-acetyl-alpha-D-glucosaminide [CPD:C04649]
Comment Brings about the acetylation of glucosamine groups of heparan
sulfate and heparin from which the sulfate has been removed. Also
acts on heparin. Not identical with EC 2.3.1.3 glucosamine
N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate
N-acetyltransferase.
Pathway PATH: ec00531  Glycosaminoglycan degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K10532  heparan-alpha-glucosaminide N-acetyltransferase
Genes HSA: 138050(HGSNAT)
PTR: 464155(HGSNAT)
MCC: 720331
MMU: 52120(Hgsnat)
RNO: 361165(RGD1560755)
CFA: 482833(HGSNAT)
BTA: 511607(HGSNAT)
ECB: 100053359
MDO: 100015953 100033053
OAA: 100086649
GGA: 422490(HGSNAT)
DRE: 565246 568024
BFO: BRAFLDRAFT_251788
CIN: 100185618
SPU: 584064 590342
DME: Dmel_CG6903
DPO: Dpse_GA19944
DAN: Dana_GF20351
DER: Dere_GG18736
DPE: Dper_GL15027
DSE: Dsec_GM12376
DSI: Dsim_GD16714
DYA: Dyak_GE16376
DGR: Dgri_GH12115
DMO: Dmoj_GI16326
AGA: AgaP_AGAP005761
AAG: AaeL_AAEL000933
CQU: CpipJ_CPIJ000061
AME: 413119 551314
NVI: 100113968
TCA: 655343 663306
API: 100159605
ISC: IscW_ISCW000750
NVE: NEMVE_v1g160704 NEMVE_v1g87128
HMG: 100199128
TAD: TRIADDRAFT_54611 TRIADDRAFT_59909
ATH: AT5G27730
POP: POPTR_1096163 POPTR_898175 POPTR_915861
RCU: RCOM_1353730
VVI: 100243512
OSA: 4326815(Os01g0931100)
SBI: SORBI_03g044830(SORBIDRAFT_03g044830)
ZMA: 100193372(gpm184)
PPP: PHYPADRAFT_136084
MBR: MONBRDRAFT_30330
DDI: DDB_0234045
Taxonomy
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:33384]
Klein U, Kresse H, von Figura K.
Sanfilippo syndrome type C: deficiency of
acetyl-CoA:alpha-glucosaminide N-acetyltransferase in skin
fibroblasts.
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 5185-9.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:7346380]
Pohlmann R, Klein U, Fromme HG, von Figura K.
Localisation of acetyl-CoA: alpha-glucosaminide N-acetyltransferase
in microsomes and lysosomes of rat liver.
Hoppe. Seylers. Z. Physiol. Chem. 362 (1981) 1199-207.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 2.3.1.78
IUBMB Enzyme Nomenclature: 2.3.1.78
ExPASy - ENZYME nomenclature database: 2.3.1.78
BRENDA, the Enzyme Database: 2.3.1.78
CAS: 79955-83-2
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