KEGG   ENZYME: 2.3.1.78Help
Entry
EC 2.3.1.78                 Enzyme                                 
Name
heparan-alpha-glucosaminide N-acetyltransferase;
acetyl-CoA:alpha-glucosaminide N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide [RN:R04466 R07815]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
heparan sulfate alpha-D-glucosaminide [CPD:C04384]
Product
CoA [CPD:C00010];
heparan sulfate N-acetyl-alpha-D-glucosaminide [CPD:C04649]
Comment
Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase.
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K10532  
heparan-alpha-glucosaminide N-acetyltransferase
Genes
HSA: 
138050(HGSNAT)
PTR: 
464155(HGSNAT)
PPS: 
100984595(HGSNAT)
GGO: 
101149295(HGSNAT)
PON: 
100447325(HGSNAT)
MCC: 
MMU: 
52120(Hgsnat)
CFA: 
482833(HGSNAT)
AML: 
FCA: 
101101049(HGSNAT)
BTA: 
511607(HGSNAT)
SSC: 
100517562
ECB: 
100053359
MDO: 
100015953 100033053(HGSNAT)
SHR: 
100926947 100930224(HGSNAT)
OAA: 
100086649(HGSNAT)
GGA: 
422490(HGSNAT)
MGP: 
100540377(HGSNAT)
TGU: 
100228309
ACS: 
100567269(hgsnat)
XTR: 
100485725(hgsnat)
DRE: 
565246 568024
TRU: 
101077979 101078824
OLA: 
101155794 101166687
BFO: 
BRAFLDRAFT_217958 BRAFLDRAFT_251788
CIN: 
100185618
SPU: 
584064 590342
DME: 
Dmel_CG6903
DPO: 
Dpse_GA19944
DAN: 
Dana_GF20351
DER: 
Dere_GG18736
DPE: 
Dper_GL15027
DSE: 
Dsec_GM12376
DSI: 
Dsim_GD16714
DWI: 
Dwil_GK25317
DYA: 
Dyak_GE16376
DGR: 
Dgri_GH12115
DMO: 
Dmoj_GI16326
DVI: 
Dvir_GJ15666
AGA: 
AgaP_AGAP005761
AAG: 
AaeL_AAEL000933
CQU: 
CpipJ_CPIJ000061
AME: 
413119 551314
NVI: 
100113968(NV17676)
TCA: 
655343 663306
API: 
100159605
PHU: 
Phum_PHUM127270 Phum_PHUM535950
ISC: 
IscW_ISCW000750
NVE: 
NEMVE_v1g160704 NEMVE_v1g87128
HMG: 
100199128
TAD: 
TRIADDRAFT_54611 TRIADDRAFT_59909
AQU: 
100639521
ATH: 
AT5G27730
ALY: 
ARALYDRAFT_489556
GMX: 
100797783 100802361 100816453 100819967
MTR: 
MTR_1g087750 MTR_7g112720
CSV: 
101210116 101216301 101220222 101224463
RCU: 
RCOM_1348030 RCOM_1353730
POP: 
POPTR_1096163 POPTR_1115737 POPTR_898175 POPTR_915861
VVI: 
100243512 100264954
OSA: 
4326815
DOSA: 
Os01t0931100-02(Os01g0931100)
BDI: 
100824114 100839989
SBI: 
SORBI_03g044830(SORBIDRAFT_03g044830)
ZMA: 
100193372(gpm184)
SMO: 
SELMODRAFT_119497 SELMODRAFT_75452 SELMODRAFT_78688
PPP: 
PHYPADRAFT_117698 PHYPADRAFT_136084
MBR: 
MONBRDRAFT_30330
DDI: 
DDB_G0286315
DPP: 
DICPUDRAFT_49381
 » show all
Taxonomy
Reference
1  [PMID:33384]
  Authors
Klein U, Kresse H, von Figura K.
  Title
Sanfilippo syndrome type C: deficiency of acetyl-CoA:alpha-glucosaminide N-acetyltransferase in skin fibroblasts.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 5185-9.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:7346380]
  Authors
Pohlmann R, Klein U, Fromme HG, von Figura K.
  Title
Localisation of acetyl-CoA: alpha-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 362 (1981) 1199-207.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
79955-83-2
DBGET integrated database retrieval system