KEGG   ENZYME: 2.3.1.78Help
Entry
EC 2.3.1.78                 Enzyme                                 

Name
heparan-alpha-glucosaminide N-acetyltransferase;
acetyl-CoA:alpha-glucosaminide N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide [RN:R04466 R07815]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
heparan sulfate alpha-D-glucosaminide [CPD:C04384]
Product
CoA [CPD:C00010];
heparan sulfate N-acetyl-alpha-D-glucosaminide [CPD:C04649]
Comment
Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase.
History
EC 2.3.1.78 created 1984
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K10532  
heparan-alpha-glucosaminide N-acetyltransferase
Genes
HSA: 
138050(HGSNAT)
PTR: 
464155(HGSNAT)
PPS: 
100984595(HGSNAT)
GGO: 
101149295(HGSNAT)
PON: 
100447325(HGSNAT)
MCC: 
MCF: 
MMU: 
52120(Hgsnat)
CGE: 
HGL: 
TUP: 
102478224(HGSNAT)
CFA: 
482833(HGSNAT)
AML: 
FCA: 
101101049(HGSNAT)
PTG: 
102958238(HGSNAT)
BTA: 
511607(HGSNAT)
BOM: 
102272015(HGSNAT)
PHD: 
102332946(HGSNAT)
CHX: 
102179068(HGSNAT)
SSC: 
100517562(HGSNAT)
CFR: 
102515446(HGSNAT)
ECB: 
100053359(HGSNAT)
MYB: 
102255817(HGSNAT)
MYD: 
102753313(HGSNAT)
PALE: 
102898024(HGSNAT)
MDO: 
SHR: 
OAA: 
100086649(HGSNAT)
GGA: 
422490(HGSNAT)
MGP: 
100540377(HGSNAT)
TGU: 
FAB: 
101811325(HGSNAT)
PHI: 
102113040(HGSNAT)
APLA: 
FPG: 
101916028(HGSNAT)
FCH: 
102048397(HGSNAT)
CLV: 
102088426(HGSNAT)
ASN: 
PSS: 
CMY: 
102929508(HGSNAT)
ACS: 
100567269(hgsnat)
XTR: 
100485725(hgsnat)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413119(GB19592) 551314(GB11225)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0004s18250g(POPTRDRAFT_556656) POPTR_0005s02530g POPTR_0006s12440g POPTR_0009s13900g(POPTRDRAFT_557061) POPTR_0013s01760g(POPTRDRAFT_1096163) POPTR_0014s11890g(POPTRDRAFT_898175)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os05t0155700-01(Os05g0155700)
OBR: 
BDI: 
SBI: 
SORBI_03g044830(SORBIDRAFT_03g044830) SORBI_05g006970(SORBIDRAFT_05g006970)
ZMA: 
SITA: 
ATR: 
s00045p00217350(AMTR_s00045p00217350) s00057p00089970(AMTR_s00057p00089970) s00131p00031270(AMTR_s00131p00031270)
SMO: 
PPP: 
CSL: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:33384]
  Authors
Klein U, Kresse H, von Figura K.
  Title
Sanfilippo syndrome type C: deficiency of acetyl-CoA:alpha-glucosaminide N-acetyltransferase in skin fibroblasts.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 5185-9.
  Organism
Homo sapiens
Reference
2  [PMID:7346380]
  Authors
Pohlmann R, Klein U, Fromme HG, von Figura K.
  Title
Localisation of acetyl-CoA: alpha-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 362 (1981) 1199-207.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
79955-83-2

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