KEGG   ENZYME: 2.3.1.86Help
Entry
EC 2.3.1.86                 Enzyme                                 

Name
fatty-acyl-CoA synthase;
yeast fatty acid synthase;
FAS1 (gene name);
FAS2 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ [RN:R05190]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain-acyl-CoA;
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, 3-oxoacyl-[acyl-carrier-protein] synthase, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid ester dehydrogenase. The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
History
EC 2.3.1.86 created 1984, modified 2003, modified 2013
Pathway
Fatty acid biosynthesis
Metabolic pathways
Orthology
K00667  
fatty acid synthase subunit alpha, fungi type
K00668  
fatty acid synthase subunit beta, fungi type
Genes
SCE: 
YKL182W(FAS1) YPL231W(FAS2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0G01260(NCAS0G01260) NCAS_0J01680(NCAS0J01680)
NDI: 
NDAI_0F01390(NDAI0F01390) NDAI_0J02670(NDAI0J02670)
TPF: 
TPHA_0B02040(TPHA0B02040) TPHA_0H01860(TPHA0H01860)
TBL: 
TBLA_0C02010(TBLA0C02010) TBLA_0I03120(TBLA0I03120)
TDL: 
TDEL_0A06700(TDEL0A06700) TDEL_0C04130(TDEL0C04130) TDEL_0E00900(TDEL0E00900)
KAF: 
KAFR_0A05730(KAFR0A05730) KAFR_0F01200(KAFR0F01200)
DHA: 
PIC: 
PGU: 
LEL: 
SPAA: 
CAL: 
CTP: 
CDU: 
COT: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_156104(AO090124000083) AOR_1_158104(AO090124000084) AOR_1_184024(AO090010000107) AOR_1_26014(AO090026000012) AOR_1_276024(AO090010000156) AOR_1_28014(AO090026000013) AOR_1_300024(AO090010000171) AOR_1_62054(AO090011000040) AOR_1_74054(AO090011000046)
ANG: 
ANI_1_1114084(An09g01740) ANI_1_1156084(An09g02010) ANI_1_1466104(An12g01980) ANI_1_202174(An10g00630) ANI_1_2488074(An08g10860) ANI_1_2494074(An08g10930) ANI_1_6014(An01g00060)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
PGR: 
ACAN: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:4590449]
  Authors
Schweizer E, Kniep B, Castorph H, Holzner U.
  Title
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
  Journal
Eur. J. Biochem. 39 (1973) 353-62.
  Organism
Saccharomyces cerevisiae
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu. Rev. Biochem. 52 (1983) 537-79.
Reference
3  [PMID:16950653]
  Authors
Tehlivets O, Scheuringer K, Kohlwein SD
  Title
Fatty acid synthesis and elongation in yeast.
  Journal
Biochim. Biophys. Acta. 1771 (2007) 255-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
94219-29-1

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