| Entry |
|
|---|
| Name |
aralkylamine N-acetyltransferase;
serotonin acetyltransferase;
serotonin acetylase;
arylalkylamine N-acetyltransferase;
serotonin N-acetyltransferase;
AANAT;
melatonin rhythm enzyme |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acetyl-CoA:2-arylethylamine N-acetyltransferase |
|---|
| Reaction(IUBMB) |
acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine
[RN:R03760] |
|---|
| Reaction(KEGG) |
R03760 > R02911
 |
|---|
| Substrate |
acetyl-CoA [CPD:C00024];
2-arylethylamine [CPD:C15534] |
|---|
| Product |
CoA [CPD:C00010];
N-acetyl-2-arylethylamine [CPD:C15535] |
|---|
| Comment |
Narrow specificity towards 2-arylethylamines, including serotonin
(5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and
phenylethylamine. This is the penultimate enzyme in the production
of melatonin (5-methoxy-N-acetyltryptamine) and controls its
synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase).
Differs from EC 2.3.1.5 arylamine N-acetyltransferase. |
|---|
| Pathway |
PATH: ec00380 Tryptophan metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00669 arylalkylamine N-acetyltransferase |
|---|
| Genes |
HSA: 15(AANAT)
PTR: 503504(AANAT)
MCC: 706924(AANAT)
MMU: 11298(Aanat)
RNO: 25120(Aanat)
CFA: 483331(AANAT)
BTA: 281583(AANAT) 618594(AANAT)
ECB: 100058770
MDO: 100026619
OAA: 100076568
GGA: 396066(AANAT)
DRE: 30685(aanat2) 393677(aanat1)
DME: Dmel_CG3318(Dat)
PIC: PICST_62543(SNA1)
 |
|---|
| Structures |
PDB: 1B6B 1IB1 1KUV 1KUX 1KUY 1L0C |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6469990]
Voisin P, Namboodiri MA, Klein DC.
Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase
in the mammalian pineal gland.
J. Biol. Chem. 259 (1984) 10913-8.
Rattus norvegicus [GN:rno], Ovis aries |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10722724]
Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange
P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E,
Fauchere JL, Boutin JA.
Substrate specificity and inhibition studies of human serotonin
N-acetyltransferase.
J. Biol. Chem. 275 (2000) 8794-805.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
|
3
Khalil, E.M. and Cole, P.A.
A potent inhibitor of the melatonin rhythm enzyme.
J. Am. Chem. Soc. 120 (1998) 6195-6196. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.87
IUBMB Enzyme Nomenclature: 2.3.1.87
ExPASy - ENZYME nomenclature database: 2.3.1.87
BRENDA, the Enzyme Database: 2.3.1.87
CAS: 92941-56-5 |
|---|
