KEGG   ENZYME: 2.3.1.87Help
Entry
EC 2.3.1.87                 Enzyme                                 

Name
aralkylamine N-acetyltransferase;
serotonin acetyltransferase;
serotonin acetylase;
arylalkylamine N-acetyltransferase;
serotonin N-acetyltransferase;
AANAT;
melatonin rhythm enzyme
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:2-arylethylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine [RN:R03760]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
2-arylethylamine [CPD:C15534]
Product
CoA [CPD:C00010];
N-acetyl-2-arylethylamine [CPD:C15535]
Comment
Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.
History
EC 2.3.1.87 created 1986, modified 2005
Pathway
Tryptophan metabolism
Metabolic pathways
Orthology
K00669  
arylalkylamine N-acetyltransferase
Genes
HSA: 
15(AANAT)
PTR: 
503504(AANAT)
PPS: 
100977321(AANAT)
GGO: 
101129527(AANAT)
PON: 
100433977(AANAT)
MCC: 
706924(AANAT)
MCF: 
102127968(AANAT)
MMU: 
11298(Aanat)
RNO: 
25120(Aanat)
CGE: 
100755392(Aanat)
HGL: 
101713893(Aanat)
TUP: 
102470373(AANAT)
CFA: 
483331(AANAT)
AML: 
FCA: 
101098178(AANAT)
PTG: 
102953543(AANAT)
BTA: 
281583(AANAT) 618594
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
102522698(AANAT)
BACU: 
103011665(AANAT)
LVE: 
103071739(AANAT)
ECB: 
100058770(AANAT)
MYB: 
102257691(AANAT)
PALE: 
102898841(AANAT)
MDO: 
100026619(AANAT)
SHR: 
100924836(AANAT)
OAA: 
100076568(AANAT)
GGA: 
396066(AANAT)
MGP: 
TGU: 
100228432(AANAT)
FAB: 
101817679(AANAT)
PHI: 
102107121(AANAT)
APLA: 
101798734(AANAT)
FPG: 
101917150(AANAT)
FCH: 
102045840(AANAT)
CLV: 
102097087(AANAT)
ASN: 
102385650(AANAT)
AMJ: 
102558329(AANAT)
PSS: 
102454343(AANAT)
CMY: 
102939980(AANAT)
ACS: 
PBI: 
103059427(AANAT)
XLA: 
100335045(aanat-a) 100335046(aanat)
XTR: 
100497589(aanat)
DRE: 
30685(aanat2) 393677(aanat1)
TRU: 
MZE: 
OLA: 
100049467(aanat1a) 100049488(aanat2) 100049507(aanat1b)
XMA: 
LCM: 
102349438(AANAT)
CMK: 
103188407(aanat)
DME: 
 » show all
Taxonomy
Reference
1  [PMID:6469990]
  Authors
Voisin P, Namboodiri MA, Klein DC.
  Title
Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.
  Journal
J. Biol. Chem. 259 (1984) 10913-8.
  Organism
Rattus norvegicus, Ovis aries
Reference
2  [PMID:10722724]
  Authors
Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchere JL, Boutin JA.
  Title
Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.
  Journal
J. Biol. Chem. 275 (2000) 8794-805.
  Organism
Homo sapiens
Reference
3
  Authors
Khalil, E.M. and Cole, P.A.
  Title
A potent inhibitor of the melatonin rhythm enzyme.
  Journal
J. Am. Chem. Soc. 120 (1998) 6195-6196.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
92941-56-5

DBGET integrated database retrieval system