KEGG   ENZYME: 2.3.2.13Help
Entry
EC 2.3.2.13                 Enzyme                                 
Name
protein-glutamine gamma-glutamyltransferase;
transglutaminase;
Factor XIIIa;
fibrinoligase;
fibrin stabilizing factor;
glutaminylpeptide gamma-glutamyltransferase;
polyamine transglutaminase;
tissue transglutaminase;
R-glutaminyl-peptide:amine gamma-glutamyl transferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
protein-glutamine:amine gamma-glutamyltransferase
Reaction(IUBMB)
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 [RN:R03983]
Reaction(KEGG)
Substrate
protein glutamine [CPD:C02583];
alkylamine [CPD:C01664]
Product
protein N5-alkylglutamine [CPD:C03636];
NH3 [CPD:C00014]
Comment
Requires Ca2+. The gamma-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII
Orthology
K00686  
protein-glutamine gamma-glutamyltransferase
K03917  
coagulation factor XIII A1 polypeptide
K05619  
transglutaminase 1
K05620  
transglutaminase 3
K05621  
transglutaminase 4
K05622  
transglutaminase 5
K05623  
transglutaminase 7
K05624  
transglutaminase 6
K05625  
transglutaminase 2
Genes
HSA: 
116179(TGM7) 2162(F13A1) 343641(TGM6) 7047(TGM4) 7051(TGM1) 7052(TGM2) 7053(TGM3) 9333(TGM5)
PTR: 
452814(TGM1) 453375(TGM5) 458043(TGM3) 458044(TGM6) 460311(TGM4) 462413(F13A1) 467667(TGM7) 469937(TGM2)
PPS: 
100977152(TGM7) 100977828(TGM5) 100978535(TGM1) 100980699(TGM4) 100982798(F13A1) 100994168(TGM3) 100994169(TGM2) 100995088(TGM6)
GGO: 
101124803(TGM1) 101138298(TGM4) 101143373(TGM6) 101144333 101149000(TGM5) 101149948(TGM7) 101154327(TGM2)
PON: 
100189556(TGM4) 100440931 100441290(TGM2) 100453552(TGM6) 100454156(TGM3) 100457869(TGM1) 100459707(TGM5) 100460447(TGM7)
MCC: 
100430348(TGM6) 706777(TGM2) 711264(F13A1) 712605(TGM5) 712676(TGM7) 714883(TGM4) 715854(TGM1) 716498(TGM3)
MMU: 
21816(Tgm1) 21817(Tgm2) 21818(Tgm3) 241636(Tgm6) 331046(Tgm4) 640543(Tgm7) 74145(F13a1) 74176(Tgm5)
RNO: 
296152(Tgm6) 366189(Tgm3) 56083(Tgm2) 60327(F13a1) 60335(Tgm1) 64679(Tgm4) 691932
CFA: 
403630(TGM1) 477180(TGM3) 478711(F13A1) 485807(TGM6) 485867(TGM2) 487522(TGM5) 487523(TGM7)
AML: 
100468726(TGM7) 100468973 100471855(TGM6) 100472103(TGM3) 100473377(TGM1) 100477542(TGM2) 100479900(F13A1)
FCA: 
101080534(F13A1) 101080542(TGM7) 101080797(TGM5) 101082066(TGM1) 101083506(TGM6) 101083762(TGM3) 101098215(TGM2)
BTA: 
281528(TGM2) 407997(TGM1) 505080(TGM3) 514767(TGM5) 536356(TGM6) 538521(TGM7) 617881(F13A1)
SSC: 
100152931(TGM7) 100153504(F13A1) 100154530 100155471(TGM6) 100156489 100158178 100523828
ECB: 
100053068(TGM3) 100054584 100060428(F13A1) 100067214(TGM6) 100070046 100070842 100630434(TGM7)
MDO: 
100011026 100011115(TGM7) 100020636(F13A1) 100022632(TGM6) 100022686 100030812 100032853
SHR: 
100913640(TGM6) 100913906(TGM3) 100918933(TGM1) 100926340(TGM5) 100926605(TGM7) 100930830(TGM2) 100931287(F13A1)
OAA: 
100074981 100079042 100082527
GGA: 
395420(F13A1) 396432(TGM2) 419215(TGM3) 420706(TGM4) 771144(TGM6)
MGP: 
100539806(F13A1) 100541357(TGM4) 100542248 100542556 100546827
TGU: 
100219158(TGM6) 100223004 100223885(TGM2) 100224907 100227373(TGM4) 100228667(F13A1)
ACS: 
100551686 100552886 100557793 100559370 100563103
XLA: 
386605(tgm2) 443836(tgm2)
XTR: 
100170618(tgm2) 100485935 100486682(tgm5) 100487465 100488625 100491279
DRE: 
323856(tgm2b) 447909(tgm2a) 559012 559691 561287(f13a1b) 566581(tgm1l1)
TRU: 
101064049 101067089 101071398 101077747
OLA: 
100049464(etgase) 101165180 101168458
BFO: 
BRAFLDRAFT_97108
CIN: 
100186234 445739(tgm2)
SPU: 
578380(etg)
TCA: 
661504
API: 
100164391
PHU: 
Phum_PHUM442960
ISC: 
IscW_ISCW013869 IscW_ISCW019478
TSP: 
Tsp_05711
NVE: 
NEMVE_v1g97278
HMG: 
100205231
AQU: 
100634778
BSU: 
BSU31270(tgl)
BSR: 
I33_3214(tgl)
BSL: 
A7A1_2238
BSH: 
BSU6051_31270(tgl)
BSY: 
I653_15025(tgl)
BSS: 
BSUW23_15185(tgl)
BST: 
GYO_3411(tgl)
BSO: 
BSNT_04600(tgl)
BSN: 
BSn5_06500(tgl)
BSQ: 
B657_31270(tgl)
BSUB: 
BEST7613_6262(tgl)
BSX: 
C663_2981(tgl)
BLI: 
BL02523(tgl)
BLD: 
BLi03298(tgl)
BAO: 
BAMF_2924(tgl)
BAY: 
RBAM_028330(tgl)
BAQ: 
BACAU_2858(tgl)
BYA: 
BANAU_3020(tgl)
BAMP: 
B938_14475(tgl)
BAML: 
BAM5036_2744(tgl)
BAZ: 
BAMTA208_15520(tgl)
BQL: 
LL3_03190(tgl)
BXH: 
BAXH7_03171(tgl)
BQY: 
MUS_3406(tgl)
BAMI: 
KSO_005010(tgl)
BAE: 
BATR1942_13460(tgl)
BHA: 
BH3970(tgl)
BAN: 
BA_4173(tgl)
BAR: 
GBAA_4173(tgl)
BAT: 
BAS3875(tgl)
BAH: 
BAMEG_4216(tgl)
BAI: 
BAA_4198(tgl)
BAX: 
H9401_3980
BAL: 
BACI_c39200(tgl)
BCE: 
BC3963(tgl)
BCZ: 
BCZK3723(tgl)
BCR: 
BCAH187_A4082(tgl)
BCB: 
BCB4264_A4066(tgl)
BCU: 
BCAH820_3978(tgl)
BCG: 
BCG9842_B1174(tgl)
BCQ: 
BCQ_3752(tgl)
BCX: 
BCA_4068(tgl)
BNC: 
BCN_3863
BCF: 
bcf_19690
BCER: 
BCK_15420(tgl)
BCY: 
Bcer98_2665(tgl)
BTK: 
BT9727_3708(tgl)
BTL: 
BALH_3589(tgl)
BTB: 
BMB171_C3628(tgl)
BTT: 
HD73_4248
BTC: 
CT43_CH3969(tgl)
BTF: 
YBT020_19475(tgl)
BTM: 
MC28_3249
BTG: 
BTB_c40960(tgl)
BTI: 
BTG_29615(tgl)
BTN: 
BTF1_18115(tgl)
BTHT: 
H175_ch4031
BWE: 
BcerKBAB4_3789(tgl)
BCL: 
ABC2191(tgl)
BPU: 
BPUM_2792(tgl)
BPF: 
BpOF4_04260(tgl)
BMQ: 
BMQ_2447
BMD: 
BMD_2424
BMH: 
BMWSH_2770(tgl)
BJS: 
MY9_3135
GKA: 
GK2914(tgl)
GTN: 
GTNG_2863(tgl)
GTH: 
Geoth_0662
GTE: 
GTCCBUS3UF5_32600
GYC: 
GYMC61_2991(tgl)
GYA: 
GYMC52_3014
GCT: 
GC56T3_0591
GMC: 
GY4MC1_0649
GGH: 
GHH_c29940(tgl)
HHD: 
HBHAL_4227(tgl)
BBE: 
BBR47_08610(tgl)
PJD: 
Pjdr2_0339(tgl)
PPY: 
PPE_02788
PPM: 
PPSC2_c3163
PPO: 
PPM_2976(tgl)
PMS: 
KNP414_00341
PMQ: 
PM3016_296
PMW: 
B2K_01500(tgl)
PTA: 
HPL003_23605(tgl)
CBO: 
CBO2291(tgl)
CBA: 
CLB_2236(tgl)
CBH: 
CLC_2219(tgl)
CBY: 
CLM_2599(tgl)
CBL: 
CLK_1739(tgl)
CBB: 
CLD_2279(tgl)
CBI: 
CLJ_B2602(tgl)
CBF: 
CLI_2345(tgl)
CBM: 
CBF_2335
CBJ: 
H04402_02394
CKL: 
CKL_0538(tgl)
CKR: 
CKR_0475(tgl)
CCL: 
Clocl_0994
CSS: 
Cst_c03560(tgl)
CSD: 
Clst_0338
MEZ: 
Mtc_0300
 » show all
Taxonomy
Reference
1  [PMID:4151471]
  Authors
Folk JE, Chung SI.
  Title
Molecular and catalytic properties of transglutaminases.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 38 (1973) 109-91.
  Organism
Cavia porcellus
Reference
2  [PMID:5928192]
  Authors
Folk JE, Cole PW.
  Title
Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity.
  Journal
J. Biol. Chem. 241 (1966) 5518-25.
  Organism
Cavia porcellus
Reference
3  [PMID:73346]
  Authors
Folk JE, Finlayson JS.
  Title
The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases.
  Journal
Adv. Protein. Chem. 31 (1977) 1-133.
Reference
4  [PMID:2877456]
  Authors
Takahashi N, Takahashi Y, Putnam FW.
  Title
Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 8019-23.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80146-85-6
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