| Entry |
|
|---|
| Name |
gamma-glutamylcyclotransferase;
gamma-glutamyl-amino acid cyclotransferase;
gamma-L-glutamylcyclotransferase;
L-glutamic cyclase;
(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing) |
|---|
| Class |
Transferases;
Acyltransferases;
Aminoacyltransferases
 |
|---|
| Sysname |
(gamma-L-glutamyl)-L-amino-acid gamma-glutamyltransferase
(cyclizing) |
|---|
| Reaction(IUBMB) |
(gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid
[RN:R03749] |
|---|
| Reaction(KEGG) |
R03749 > R02743
 |
|---|
| Substrate |
(gamma-L-glutamyl)-L-amino acid |
|---|
| Product |
5-oxoproline [CPD:C01879];
L-amino acid [CPD:C00151] |
|---|
| Comment |
The enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate,
L-alanine and glycine. |
|---|
| Pathway |
PATH: ec00480 Glutathione metabolism |
|---|
| Orthology |
KO: K00682 gamma-glutamylcyclotransferase |
|---|
| Genes |
HSA: 79017(GGCT)
PTR: 463327(GGCT)
MMU: 110175(Ggct)
RNO: 362368(Ggct)
CFA: 611603(GGCT)
BTA: 533374(GGCT)
ECB: 100069874
MDO: 100032519
OAA: 100081401
GGA: 420676(C7orf24)
TGU: 100230215
XTR: 613056(TEgg094f14.1)
DRE: 406278(ggct)
 |
|---|
| Structures |
PDB: 2PN7 2RBH |
|---|
Reference
Authors
Title
Journal
|
1
Bodnaryk, R.P. and McGirr, L.
Purification, properties and function of a unique gamma-glutamyl
cyclotransferase from the housefly, Musca domestica L.
Biochim. Biophys. Acta 315 (1973) 352-362. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5781001]
Orlowski M, Richman PG, Meister A.
Isolation and properties of gamma-L-glutamylcyclotransferase from
human brain.
Biochemistry. 8 (1969) 1048-55.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.2.4
IUBMB Enzyme Nomenclature: 2.3.2.4
ExPASy - ENZYME nomenclature database: 2.3.2.4
BRENDA, the Enzyme Database: 2.3.2.4
CAS: 9045-44-7 |
|---|
