KEGG   ENZYME: 2.3.2.4Help
Entry
EC 2.3.2.4                  Enzyme                                 

Name
gamma-glutamylcyclotransferase;
gamma-glutamyl-amino acid cyclotransferase;
gamma-L-glutamylcyclotransferase;
L-glutamic cyclase;
(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
(gamma-L-glutamyl)-L-amino-acid gamma-glutamyltransferase (cyclizing)
Reaction(IUBMB)
(gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid [RN:R03749]
Reaction(KEGG)
Substrate
(gamma-L-glutamyl)-L-amino acid
Product
5-oxoproline [CPD:C01879];
L-amino acid [CPD:C00151]
Comment
The enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine.
History
EC 2.3.2.4 created 1972
Pathway
Glutathione metabolism
Orthology
K00682  
gamma-glutamylcyclotransferase
Genes
HSA: 
79017(GGCT)
PTR: 
463327(GGCT)
PPS: 
GGO: 
101138956(GGCT)
PON: 
100444244(GGCT)
MCC: 
695547(GGCT)
MCF: 
102142709(GGCT)
MMU: 
110175(Ggct)
RNO: 
362368(Ggct)
CGE: 
100774679(Ggct)
HGL: 
101723887(Ggct)
TUP: 
102497631(GGCT)
CFA: 
611603(GGCT)
AML: 
FCA: 
101087219(GGCT)
PTG: 
102972301(GGCT)
BTA: 
533374(GGCT)
BOM: 
102265622(GGCT)
PHD: 
102343124(GGCT)
CHX: 
102187188(GGCT)
SSC: 
CFR: 
102512131(GGCT)
BACU: 
102997196(GGCT)
LVE: 
103085194(GGCT)
ECB: 
100069874(GGCT)
MYB: 
MYD: 
102766806(GGCT)
PALE: 
102887499(GGCT)
MDO: 
100032519(GGCT)
SHR: 
100919793(GGCT)
OAA: 
100081401(GGCT)
GGA: 
420676(GGCT)
MGP: 
TGU: 
FAB: 
101818892(GGCT)
PHI: 
102099497(GGCT)
APLA: 
101805349(GGCT)
FPG: 
101921074(GGCT)
FCH: 
102047880(GGCT)
CLV: 
102083440(GGCT)
ASN: 
102385482(GGCT)
AMJ: 
102567732(GGCT)
PSS: 
102455884(GGCT)
CMY: 
102934944(GGCT)
ACS: 
PBI: 
XTR: 
613056(ggct)
DRE: 
406278(ggctb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103176267(ggct)
BFO: 
SPU: 
CEL: 
CELE_C44B7.7(C44B7.7)
CBR: 
LOA: 
TAD: 
AQU: 
 » show all
Taxonomy
Reference
1
  Authors
Bodnaryk, R.P. and McGirr, L.
  Title
Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L.
  Journal
Biochim. Biophys. Acta 315 (1973) 352-362.
Reference
2  [PMID:5781001]
  Authors
Orlowski M, Richman PG, Meister A.
  Title
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain.
  Journal
Biochemistry. 8 (1969) 1048-55.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9045-44-7

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