KEGG   ENZYME: 2.3.2.5Help
Entry
EC 2.3.2.5                  Enzyme                                 

Name
glutaminyl-peptide cyclotransferase;
glutaminyl-tRNA cyclotransferase;
glutaminyl cyclase;
glutaminyl-transfer ribonucleate cyclotransferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)
Reaction(IUBMB)
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3 [RN:R04058]
Reaction(KEGG)
Substrate
L-glutaminyl-peptide [CPD:C02986]
Product
5-oxoprolyl-peptide [CPD:C02805];
NH3 [CPD:C00014]
Comment
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
History
EC 2.3.2.5 created 1972, modified 1990
Orthology
K00683  
glutaminyl-peptide cyclotransferase
Genes
HSA: 
25797(QPCT) 54814(QPCTL)
PTR: 
456135(QPCTL) 744549(QPCT)
PPS: 
100979371(QPCT) 100991841(QPCTL)
GGO: 
101132677(QPCTL) 101133593(QPCT)
PON: 
100433368(QPCTL) 100437832(QPCT)
NLE: 
100582022(QPCT) 100598189(QPCTL)
MCC: 
712233(QPCT) 715134(QPCTL)
MCF: 
102119245(QPCT) 102124146(QPCTL)
CJC: 
100396713(QPCT) 100400276(QPCTL)
MMU: 
67369(Qpctl) 70536(Qpct)
RNO: 
292687(Qpctl) 313837(RGD1562284)
CGE: 
100755692(Qpct) 100757515(Qpctl)
NGI: 
103725274(Qpct) 103749202(Qpctl)
HGL: 
101706611(Qpctl) 101707285(Qpct)
OCU: 
100338215(QPCT) 100347713(QPCTL)
TUP: 
102472989(QPCT) 102485817(QPCTL)
CFA: 
403861(QPCT) 484437(QPCTL)
AML: 
UMR: 
103657058(QPCTL) 103671573(QPCT)
FCA: 
101093478(QPCTL) 101100635(QPCT)
PTG: 
102951193(QPCT) 102969927(QPCTL)
BTA: 
281437(QPCT) 530871(QPCTL)
BOM: 
102282169(QPCT) 102282845(QPCTL)
PHD: 
102319892(QPCT) 102331411(QPCTL)
CHX: 
102172750(QPCTL) 102174483(QPCT)
OAS: 
101117870(QPCTL) 443019(QPCT)
SSC: 
100626801(QPCTL) 397424(QPCT)
CFR: 
102506286(QPCTL) 102511708(QPCT)
BACU: 
103012431(QPCT) 103015696(QPCTL)
LVE: 
103072219(QPCTL) 103083894(QPCT)
ECB: 
100065716(QPCTL) 100070174(QPCT)
MYB: 
102242729(QPCTL) 102251114(QPCT)
MYD: 
102769797(QPCTL) 102775303(QPCT)
PALE: 
102892426(QPCT) 102894066(QPCTL)
MDO: 
SHR: 
OAA: 
100077983(QPCT) 100088523(QPCTL)
GGA: 
421479(QPCT)
MGP: 
100546290(QPCT)
APLA: 
101796173(QPCT)
TGU: 
100217805(QPCT)
FAB: 
101805973(QPCT)
PHI: 
102109669(QPCT)
CCW: 
104684388(QPCT)
FPG: 
101919834(QPCT)
FCH: 
102051783(QPCT)
CLV: 
102088250(QPCT)
ASN: 
102377565(QPCT)
AMJ: 
102569232(QPCTL) 102571884(QPCT)
PSS: 
102453205(QPCT)
CMY: 
102946459(QPCT)
ACS: 
100560754(qpctl) 100563262(qpct)
PBI: 
XLA: 
447416(qpct)
XTR: 
100379672(qpctl) 549999(qpct)
DRE: 
561142(qpctla)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181784(qpct)
BFO: 
CIN: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
411943(GB13372)
NVI: 
TCA: 
BMOR: 
API: 
ISC: 
CEL: 
CELE_H27A22.1(H27A22.1)
CBR: 
BMY: 
LOA: 
TSP: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CGR: 
AOR: 
AOR_1_1504114(AO090701000860)
MBR: 
DDI: 
ACAN: 
GTT: 
TBR: 
Tb927.7.6940(Tb07.21H15.500)
NGR: 
YPN: 
XCC: 
XCB: 
XCV: 
XAC: 
XOO: 
XOM: 
MMR: 
SPZ: 
SPH: 
SPI: 
SPJ: 
SPK: 
SPF: 
SPA: 
SPB: 
CGB: 
CGT: 
SEN: 
SUS: 
GFO: 
DGE: 
 » show all
Taxonomy
Reference
1  [PMID:3597387]
  Authors
Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS.
  Title
An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.
  Journal
J. Biol. Chem. 262 (1987) 8532-6.
Reference
2  [PMID:3473473]
  Authors
Fischer WH, Spiess J.
  Title
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 3628-32.
Reference
3  [PMID:5846578]
  Authors
Messer M, Ottesen M.
  Title
Isolation and properties of glutamine cyclotransferase of dried papaya latex.
  Journal
C. R. Trav. Lab. Carlsberg. 35 (1965) 1-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-21-9

DBGET integrated database retrieval system