KEGG   ENZYME: 2.3.3.11Help
Entry
EC 2.3.3.11                 Enzyme                                 

Name
2-hydroxyglutarate synthase;
2-hydroxyglutaratic synthetase;
2-hydroxyglutaric synthetase;
alpha-hydroxyglutarate synthase;
hydroxyglutarate synthase;
2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating)
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)
Reaction(IUBMB)
propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA [RN:R00932]
Reaction(KEGG)
Substrate
propanoyl-CoA [CPD:C00100];
H2O [CPD:C00001];
glyoxylate [CPD:C00048]
Product
2-hydroxyglutarate [CPD:C02630];
CoA [CPD:C00010]
History
EC 2.3.3.11 created 1965 as EC 4.1.3.9, transferred 2002 to EC 2.3.3.11
Pathway
C5-Branched dibasic acid metabolism
Reference
1  [PMID:14491016]
  Authors
REEVES HC, AJL SJ.
  Title
Alpha-hydroxyglutaric acid synthetase.
  Journal
J. Bacteriol. 84 (1962) 186-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9024-02-6

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