| Entry |
|
|---|
| Name |
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase;
(Lea)-dependent (alpha-3/4)-fucosyltransferase;
alpha(1,3/1,4) fucosyltransferase III;
alpha-(1->4)-L-fucosyltransferase;
alpha-4-L-fucosyltransferase;
beta-acetylglucosaminylsaccharide fucosyltransferase;
FucT-II;
Lewis alpha-(1->3/4)-fucosyltransferase;
Lewis blood group alpha-(1->3/4)-fucosyltransferase;
Lewis(Le) blood group gene-dependent
alpha-(1->3/4)-L-fucosyltransferase;
blood group Lewis alpha-4-fucosyltransferase;
blood-group substance Lea-dependent fucosyltransferase;
guanosine diphosphofucose-beta-acetylglucosaminylsaccharide
4-alpha-L-fucosyltransferase;
guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase;
guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase;
3-alpha-galactosyl-N-acetylglucosaminide
4-alpha-L-fucosyltransferase;
GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
4I-alpha-L-fucosyltransferase;
GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
4I-alpha-L-fucosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R
4I-alpha-L-fucosyltransferase |
|---|
| Reaction(IUBMB) |
GDP-beta-L-fucose +
beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-
glucosaminyl-R [RN:R04553] |
|---|
| Reaction(KEGG) |
R04553 > R06155(G);
(other) R06162(G) R06163(G) R06164(G) R06165(G)
 |
|---|
| Substrate |
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R |
|---|
| Product |
GDP [CPD:C00035];
beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-
glucosaminyl-R |
|---|
| Comment |
This enzyme is the product of the Lewis blood group gene. Normally
acts on a glycoconjugate where R (see reaction) is a glycoprotein or
glycolipid. Although it is a 4-fucosyltransferase, it has a
persistent 3-fucosyltransferase activity towards the glucose residue
in free lactose. This enzyme fucosylates on O-4 of an
N-acetylglucosamine that carries a galactosyl group on O-3, unlike
EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide
3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an
N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes
catalysing the 4-alpha-fucosylation of the GlcNAc in
beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as
3-alpha-fucosyltransferases) are present in plants, where the
function in vivo is the modification of N-glycans. In addition, the
fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase
with both 3-alpha- and 4-alpha-fucosyltransferase activities. |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00716 galactoside 3(4)-fucosyltransferase 3
KO: K07633 galactoside alpha-1,3-fucosyltransferase 5
KO: K07634 galactoside alpha-1,3-fucosyltransferase 6 |
|---|
| Genes |
HSA: 2525(FUT3) 2527(FUT5) 2528(FUT6)
PTR: 455628(FUT5) 493975(FUT3) 493976(FUT6)
MCC: 697582(FUT3)
CFA: 449024(FUT5)
BTA: 338077(FUT5)
GGA: 428341(FUT3)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7287719]
Prieels JP, Monnom D, Dolmans M, Beyer TA, Hill RL.
Co-purification of the Lewis blood group N-acetylglucosaminide alpha
1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1
goes to 3 fucosyltransferase from human milk.
J. Biol. Chem. 256 (1981) 10456-63.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10671538]
Rasko DA, Wang G, Palcic MM, Taylor DE.
Cloning and characterization of the alpha(1,3/4) fucosyltransferase
of Helicobacter pylori.
J. Biol. Chem. 275 (2000) 4988-94.
Helicobacter pylori |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:12084979]
Wilson IB.
Identification of a cDNA encoding a plant Lewis-type
alpha1,4-fucosyltransferase.
Glycoconj. J. 18 (2001) 439-47.
Solanum lycopersicum |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:12676935]
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE.
C-terminal amino acids of Helicobacter pylori alpha1,3/4
fucosyltransferases determine type I and type II transfer.
J. Biol. Chem. 278 (2003) 21893-900.
Helicobacter pylori |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.65
IUBMB Enzyme Nomenclature: 2.4.1.65
ExPASy - ENZYME nomenclature database: 2.4.1.65
BRENDA, the Enzyme Database: 2.4.1.65
CAS: 37277-69-3 |
|---|
