| Entry |
|
|---|
| Name |
alpha-1,3-mannosyl-glycoprotein
2-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase I;
N-glycosyl-oligosaccharide-glycoprotein
N-acetylglucosaminyltransferase I;
uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein
beta-1,2-N-acetylglucosaminyltransferase;
UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-
acetylglucosaminyltransferase I;
UDP-N-acetylglucosaminyl:alpha-3-D-mannoside
beta-1,2-N-acetylglucosaminyltransferase I;
alpha-1,3-mannosyl-glycoprotein
beta-1,2-N-acetylglucosaminyltransferase;
GnTI |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glyc
oprotein 2-beta-N-acetyl-D-glucosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R
= UDP +
3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-
mannosyl-R [RN:R05983] |
|---|
| Reaction(KEGG) |
R05983(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-glucosamine [CPD:C00043];
3-(alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04614] |
|---|
| Product |
UDP [CPD:C00015];
3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-
mannosyl-R [CPD:C04880] |
|---|
| Comment |
R represents the remainder of the N-linked oligosaccharide in the
glycoprotein acceptor. Note that this enzyme acts before
N-acetylglucosaminyltransferases II, III, IV, V and VI (click here
for diagram). |
|---|
| Pathway |
PATH: ec00510 N-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00726 alpha-1,3-mannosyl-glycoprotein
beta-1,2-N-acetylglucosaminyltransferase |
|---|
| Genes |
HSA: 4245(MGAT1)
PTR: 462340(MGAT1)
MCC: 707375(MGAT1)
MMU: 17308(Mgat1)
RNO: 81519(Mgat1)
CFA: 491674(MGAT1)
BTA: 534248(MGAT1)
SSC: 780412
ECB: 100057819
MDO: 100019068
OAA: 100078839
TGU: 100223060
XLA: 379038(gntI) 379047(MGC52514)
XTR: 496815(mgat1)
DRE: 393649 558524
BFO: BRAFLDRAFT_227954
SPU: 594485
DME: Dmel_CG13431(Mgat1)
DPO: Dpse_GA12283
DAN: Dana_GF12760
DER: Dere_GG20851
DPE: Dper_GL10391
DSE: Dsec_GM19778
DSI: Dsim_GD25269
DYA: Dyak_GE13790
DGR: Dgri_GH22116
DMO: Dmoj_GI19251
AGA: AgaP_AGAP005347
AAG: AaeL_AAEL002329
CQU: CpipJ_CPIJ003929
AME: 410105
NVI: 100117242
TCA: 662130
API: 100160307
ISC: IscW_ISCW009302
CEL: B0416.6(gly-13) F48E3.1(gly-12) M01F1.1(gly-14)
CBR: CBG09783 CBG16168 CBG16700
BMY: Bm1_21155
SMM: Smp_026930
NVE: NEMVE_v1g101514
HMG: 100210187
TAD: TRIADDRAFT_19831
ATH: AT4G38240(CGL1)
POP: POPTR_1085909
RCU: RCOM_0600390
VVI: 100266799
OSA: 4331263(Os02g0832800)
SBI: SORBI_08g003660(SORBIDRAFT_08g003660)
ZMA: 100274447
PPP: PHYPADRAFT_214349
MBR: MONBRDRAFT_28515
DDI: DDB_0231456(gnt3)
PTI: PHATRDRAFT_54844
 |
|---|
| Structures |
PDB: 1FO8 1FO9 1FOA 2AM3 2AM4 2AM5 2APC |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6445358]
Harpaz N, Schachter H.
Control of glycoprotein synthesis. Bovine colostrum
UDP-N-acetylglucosamine:alpha-D-mannoside beta
2-N-acetylglucosaminyltransferase I. Separation from
UDP-N-acetylglucosamine:alpha-D-mannoside beta
2-N-acetylglucosaminyltransferase II, partial purification, and
substrate specificity.
J. Biol. Chem. 255 (1980) 4885-93.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6452163]
Mendicino J, Chandrasekaran EV, Anumula KR, Davila M.
Isolation and properties of
alpha-D-mannose:beta-1,2-N-acetylglucosaminyltransferase from
trachea mucosa.
Biochemistry. 20 (1981) 967-76.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6170335]
Miyagi T, Tsuiki S.
Studies on UDP-N-acetylglucosamine : alpha-mannoside
beta-N-acetylglucosaminyltransferase of rat liver and hepatomas.
Biochim. Biophys. Acta. 661 (1981) 148-57.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6457827]
Oppenheimer CL, Eckhardt AE, Hill RL.
The nonidentity of porcine N-acetylglucosaminyltransferases I and
II.
J. Biol. Chem. 256 (1981) 11477-82.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:6450208]
Oppenheimer CL, Hill RL.
Purification and characterization of a rabbit liver alpha 1 goes to
3 mannoside beta 1 goes to 2 N-acetylglucosaminyltransferase.
J. Biol. Chem. 256 (1981) 799-804.
Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
|
6 [PMID:6366476]
Schachter H, Narasimhan S, Gleeson P, Vella G.
Glycosyltransferases involved in elongation of N-glycosidically
linked oligosaccharides of the complex or N-acetyllactosamine type.
Methods. Enzymol. 98 (1983) 98-134. |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:6235906]
Vella GJ, Paulsen H, Schachter H.
Control of glycoprotein synthesis. IX. A terminal Man alpha l-3Man
beta 1- sequence in the substrate is the minimum requirement for
UDP-N-acetyl-D-glucosamine: alpha-D-mannoside (GlcNAc to Man alpha
1-3) beta 2-N-acetylglucosaminyltransferase I.
Can. J. Biochem. Cell. Biol. 62 (1984) 409-17.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
8 [PMID:11032794]
Unligil UM, Zhou S, Yuwaraj S, Sarkar M, Schachter H, Rini JM.
X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I:
catalytic mechanism and a new protein superfamily.
EMBO. J. 19 (2000) 5269-80.
Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.101
IUBMB Enzyme Nomenclature: 2.4.1.101
ExPASy - ENZYME nomenclature database: 2.4.1.101
BRENDA, the Enzyme Database: 2.4.1.101
CAS: 102576-81-8 |
|---|
