KEGG   ENZYME: 2.4.1.102Help
Entry
EC 2.4.1.102                Enzyme                                 

Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I;
beta6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase;
core 2 acetylglucosaminyltransferase;
core 6-beta-GlcNAc-transferase A;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl-R [RN:R04575 R05912]
Reaction(KEGG)
R04575 R05912(G);
(other) R05910(G)
Show
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [CPD:C04750]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl-R [CPD:C04902]
Comment
The enzyme is involved in O-glycosylation of several proteins, such as mucins.
History
EC 2.4.1.102 created 1983
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K00727  
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Genes
HSA: 
2650(GCNT1)
PTR: 
472959(GCNT1)
PPS: 
100990909(GCNT1)
GGO: 
101144738(GCNT1)
PON: 
100453351(GCNT1)
MCC: 
704639(GCNT1)
MCF: 
102121951(GCNT1)
MMU: 
14537(Gcnt1)
RNO: 
64043(Gcnt1)
CGE: 
100767124(Gcnt1)
HGL: 
101713056(Gcnt1)
TUP: 
102474618(GCNT1)
CFA: 
484158(GCNT1)
AML: 
100481771(GCNT1)
FCA: 
101093969(GCNT1)
PTG: 
102952027(GCNT1)
BTA: 
281778(GCNT1)
BOM: 
102285997(GCNT1)
PHD: 
102317499(GCNT1)
CHX: 
102187590(GCNT1)
OAS: 
101121316(GCNT1)
SSC: 
100157004(GCNT1)
CFR: 
102509033(GCNT1)
BACU: 
103015488(GCNT1)
LVE: 
103084201(GCNT1)
ECB: 
100061416(GCNT1)
MYB: 
102248045(GCNT1)
MYD: 
102759783(GCNT1)
PALE: 
102898105(GCNT1)
MDO: 
100011966(GCNT1)
SHR: 
OAA: 
100075656(GCNT1)
GGA: 
427260(GCNT1)
MGP: 
TGU: 
100221628(GCNT1)
FAB: 
101808578(GCNT1)
PHI: 
102103854(GCNT1)
APLA: 
101796875(GCNT1)
FPG: 
101912116(GCNT1)
FCH: 
102047162(GCNT1)
CLV: 
102085044(GCNT1)
ASN: 
102385228(GCNT1)
AMJ: 
PSS: 
102449351(GCNT1)
CMY: 
102941735(GCNT1)
ACS: 
100565751(gcnt1)
PBI: 
103048092(GCNT1)
XLA: 
380501(gcnt1)
XTR: 
100490337(gcnt1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102357208(GCNT1)
CMK: 
CEL: 
CELE_T15D6.2(gly-16)
CBR: 
CBG04363(Cbr-gly-15)
 » show all
Taxonomy
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr. Res. 120 (1983) 3-16.
Reference
2  [PMID:6449508]
  Authors
Williams D, Longmore G, Matta KL, Schachter H.
  Title
Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase.
  Journal
J. Biol. Chem. 255 (1980) 11253-61.
Reference
3  [PMID:6449507]
  Authors
Williams D, Schachter H.
  Title
Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.
  Journal
J. Biol. Chem. 255 (1980) 11247-52.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
95978-15-7

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