| Entry |
|
|---|
| Name |
beta-1,3-galactosyl-O-glycosyl-glycoprotein
beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein
N-acetylglucosaminyltransferase I;
beta6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-mucin
beta-(1->6)-acetylglucosaminyltransferase;
core 2 acetylglucosaminyltransferase;
core 6-beta-GlcNAc-transferase A;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein
(N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of
beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R)
beta-1,6-N-acetyl-D-glucosaminyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
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| Sysname |
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein
(N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of
beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R)
6-beta-N-acetyl-D-glucosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine +
beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP +
beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-
acetyl-D-galactosaminyl-R [RN:R04575 R05912] |
|---|
| Reaction(KEGG) |
R04575 R05912(G);
(other) R05910(G)
 |
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| Substrate |
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R |
|---|
| Product |
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-
acetyl-D-galactosaminyl-R |
|---|
| Comment |
cf. EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein
beta-1,3-N-acetylglucosaminyltransferase), EC 2.4.1.147
(acetylgalactosaminyl-O-glycosyl-glycoprotein
beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148
(acetylgalactosaminyl-O-glycosyl-glycoprotein
beta-1,6-N-acetylglucosaminyltransferase). |
|---|
| Pathway |
PATH: ec00512 O-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00727 beta-1,3-galactosyl-O-glycosyl-glycoprotein
beta-1,6-N-acetylglucosaminyltransferase |
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| Genes |
HSA: 2650(GCNT1)
PTR: 472959(GCNT1)
MCC: 704639(GCNT1)
MMU: 14537(Gcnt1)
RNO: 64043(Gcnt1)
CFA: 484158(GCNT1)
BTA: 281778(GCNT1)
SSC: 100157004
ECB: 100061416(GCNT1)
MDO: 100011966
OAA: 100075656(GCNT1)
GGA: 427260(GCNT1)
TGU: 100221628
XLA: 380501(gcnt1)
CEL: T15D6.2(gly-16)
 |
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| Structures |
PDB: 2GAK 2GAM |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:6226356]
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
The separation by liquid chromatography (under elevated pressure) of
phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides.
Analysis of substrates and products for four
N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
Carbohydr. Res. 120 (1983) 3-16.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6449508]
Williams D, Longmore G, Matta KL, Schachter H.
Mucin synthesis. II. Substrate specificity and product
identification studies on canine submaxillary gland UDP-GlcNAc:Gal
beta 1-3GalNAc(GlcNAc leads to GalNAc) beta
6-N-acetylglucosaminyltransferase.
J. Biol. Chem. 255 (1980) 11253-61.
Canis familiaris [GN:cfa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6449507]
Williams D, Schachter H.
Mucin synthesis. I. Detection in canine submaxillary glands of an
N-acetylglucosaminyltransferase which acts on mucin substrates.
J. Biol. Chem. 255 (1980) 11247-52.
Sus scofa [GN:ssc], Ovis aries |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.102
IUBMB Enzyme Nomenclature: 2.4.1.102
ExPASy - ENZYME nomenclature database: 2.4.1.102
BRENDA, the Enzyme Database: 2.4.1.102
CAS: 95978-15-7 |
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