| Entry |
|
| Name |
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I;
beta6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase;
core 2 acetylglucosaminyltransferase;
core 6-beta-GlcNAc-transferase A;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase
|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
| Sysname |
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase
|
| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R [RN: R04575 R05912]
|
| Reaction(KEGG) |
|
| Substrate |
UDP-N-acetyl-D-glucosamine [CPD: C00043];
beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R
|
| Product |
UDP [CPD: C00015];
beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R
|
| Comment |
cf. EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase), EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).
|
| Pathway |
| Mucin type O-Glycan biosynthesis | | Metabolic pathways |
|
| Orthology |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | TRU: | | OLA: | | CEL: | | CBR: | | » show all
 |
| Reference |
|
| Authors |
Brockhausen I, Rachaman ES, Matta KL, Schachter H. |
| Title |
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis. |
| Journal |
Carbohydr. Res. 120 (1983) 3-16. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Williams D, Longmore G, Matta KL, Schachter H. |
| Title |
Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase. |
| Journal |
J. Biol. Chem. 255 (1980) 11253-61. |
| Organism |
Canis familiaris [GN: cfa] |
| Reference |
|
| Authors |
Williams D, Schachter H. |
| Title |
Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates. |
| Journal |
J. Biol. Chem. 255 (1980) 11247-52. |
| Organism |
Sus scofa [GN: ssc], Ovis aries |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 95978-15-7 |