KEGG   ENZYME: 2.4.1.11Help
Entry
EC 2.4.1.11                 Enzyme                                 

Name
glycogen(starch) synthase;
UDP-glucose---glycogen glucosyltransferase;
glycogen (starch) synthetase;
UDP-glucose-glycogen glucosyltransferase;
UDP-glycogen synthase;
UDPG-glycogen synthetase;
UDPG-glycogen transglucosylase;
uridine diphosphoglucose-glycogen glucosyltransferase;
UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:glycogen 4-alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl]n = UDP + [(1->4)-alpha-D-glucosyl]n+1 [RN:R00292 R06051]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
[(1->4)-alpha-D-glucosyl]n
Product
UDP [CPD:C00015];
[(1->4)-alpha-D-glucosyl]n+1
Comment
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
History
EC 2.4.1.11 created 1961
Pathway
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
Orthology
K00693  glycogen synthase
K16150  glycogen synthase
K16153  glycogen phosphorylase/synthase
Genes
HSA: 2997(GYS1) 2998(GYS2)
PTR: 456196(GYS1) 465336(GYS2)
PPS: 100972797(GYS2) 100990031(GYS1)
GGO: 101131537(GYS2) 101132203(GYS1)
PON: 100172871(GYS1) 100452879(GYS2)
NLE: 100579728(GYS1) 101177222(GYS2)
MCC: 574233(GYS1) 706152(GYS2)
MCF: 102134439(GYS1) 102145637(GYS2)
CSAB: 103218736(GYS2) 103235009(GYS1)
RRO: 104660892(GYS2) 104666538(GYS1)
RBB: 108523620(GYS1) 108539726(GYS2)
CJC: 100406574(GYS1)
SBQ: 101040983(GYS2) 101050509(GYS1)
MMU: 14936(Gys1) 232493(Gys2)
RNO: 25623(Gys2) 690987(Gys1)
CGE: 100769788(Gys1) 100770628(Gys2)
NGI: 103743640(Gys1) 103748807(Gys2)
HGL: 101699800(Gys2) 101712358(Gys1)
OCU: 100008660(GYS1) 100352840(GYS2)
TUP: 102469649(GYS1) 102472146(GYS2)
CFA: 403737(GYS2) 611993(GYS1)
AML: 100470220(GYS2) 100476206(GYS1)
UMR: 103657110(GYS1) 103665227(GYS2)
ORO: 101368722(GYS2) 101370584(GYS1)
FCA: 101092123(GYS2) 101100682(GYS1)
PTG: 102950123(GYS1) 102965400(GYS2)
AJU: 106967981(GYS2) 106988702(GYS1)
BTA: 511047(GYS1) 537451(GYS2) 786335(GYS1)
BOM: 102272943(GYS2) 102278988(GYS1)
BIU: 109559597(GYS2) 109571966 109572216(GYS1)
PHD: 102324800(GYS1) 102332125(GYS2)
CHX: 102188970(GYS1) 102189015(GYS2)
OAS: 101108772(GYS1) 101118685(GYS2)
SSC: 100157080(GYS2) 574064(GYS1)
CFR: 102511249(GYS1) 102511313(GYS2)
CDK: 105096485(GYS2) 105102888(GYS1)
BACU: 103007749(GYS2) 103019791(GYS1)
LVE: 103074944(GYS2) 103084996(GYS1)
OOR: 101284496(GYS1) 101287552(GYS2)
ECB: 100054723(GYS1) 100064264(GYS2)
EPZ: 103553309(GYS1) 103554933(GYS2)
EAI: 106825573(GYS2) 106838266(GYS1)
MYB: 102251419(GYS2) 102262755(GYS1)
MYD: 102771674(GYS2) 102775147(GYS1)
HAI: 109375142(GYS2) 109390996(GYS1)
RSS: 109450635(GYS2) 109452589(GYS1)
PALE: 102884634(GYS1) 102890809(GYS2)
LAV: 100658178(GYS2) 100659799(GYS1)
MDO: 100010618(GYS2) 100030435(GYS1)
SHR: 100918400(GYS2) 100920298(GYS1)
OAA: 100074446(GYS1)
GGA: 418201(GYS2)
MGP: 100547308(GYS2)
CJO: 107316995(GYS2)
APLA: 101795011(GYS2)
ACYG: 106038297(GYS2)
TGU: 100232653(GYS2)
GFR: 102038432(GYS2)
FAB: 101821843(GYS2)
PHI: 102105522(GYS2) 102106773(GYS1)
PMAJ: 107205059(GYS2)
CCW: 104696143(GYS2)
FPG: 101918224(GYS2) 106112713(GYS1)
FCH: 102051571(GYS2)
CLV: 102095088(GYS2)
EGZ: 104135134(GYS2)
AAM: 106486701 106488410(GYS2)
ASN: 102372928(GYS1) 102375223(GYS2)
AMJ: 102573726(GYS1) 106737074(GYS2)
PSS: 102449457(GYS2) 102462946(GYS1)
CMY: 102943466(GYS1) 102944417(GYS2)
CPIC: 101939182(GYS2) 101947252(GYS1)
ACS: 100555409(gys2) 100563034(gys1)
PVT: 110078508(GYS1) 110083005(GYS2)
PBI: 103048016(GYS1) 103058373(GYS2)
GJA: 107116591(GYS1) 107122425
XLA: 108696758 108697802 431912(gys2.L)
XTR: 100490155(gys1) 548515(gys2)
DRE: 373082(gys2) 394155(gys1)
IPU: 108256446(gys1) 108279630(gys2)
AMEX: 103022388 103040242(gys2)
TRU: 101077099(gys1) 101079536(gys2)
LCO: 104927634(gys2) 104930340(gys1) 109142472
MZE: 101474059(gys2) 101485531(gys1)
OLA: 101155437(gys1) 101163866(gys2)
XMA: 102217274 102233516(gys1)
PRET: 103459579(gys2) 103469092(gys1)
NFU: 107376658 107381436(gys2)
CSEM: 103383026(gys2) 103392977
HCQ: 109514852(gys1) 109520116(gys2)
BPEC: 110158208(gys1) 110162197 110172488(gys2)
ELS: 105007707 105020183(gys2)
LCM: 102359961(GYS2) 102360620(GYS1)
CIN: 100183713
SPU: 578305
APLC: 110975475
SKO: 100368259
DME: Dmel_CG6904(GlyS)
DSI: Dsimw501_GD20381(Dsim_GD20381)
MDE: 101890004
AAG: 5564353
AME: 552328
BIM: 100748309
BTER: 100647195
SOC: 105206087
AEC: 105155041
ACEP: 105620164
PBAR: 105432338
HST: 105182643
CFO: 105249547
LHU: 105669367
PGC: 109860044
NVI: 100119226
TCA: 662050
DPA: 109542106
NVL: 108564856
BMOR: 101736417
PMAC: 106716340
PRAP: 110996075
API: 100166026
ZNE: 110833071
FCD: 110845614
TUT: 107372104
CEL: CELE_Y46G5A.31(gsy-1)
CBR: CBG18401(Cbr-gsy-1)
TSP: Tsp_00121
CRG: 105341160
MYI: 110453713
OBI: 106882342
LAK: 106168839
SHX: MS3_08291
EPA: 110233733
HMG: 100197472(gys1)
AQU: 100640802
SCE: YFR015C(GSY1) YLR258W(GSY2)
ERC: Ecym_1276
KMX: KLMA_30370(GSY2)
NCS: NCAS_0A08870(NCAS0A08870) NCAS_0D00640(NCAS0D00640)
NDI: NDAI_0G05290(NDAI0G05290) NDAI_0H03510(NDAI0H03510)
TPF: TPHA_0B03550(TPHA0B03550) TPHA_0O01130(TPHA0O01130)
TBL: TBLA_0D05020(TBLA0D05020)
TDL: TDEL_0B06310(TDEL0B06310)
KAF: KAFR_0C04470(KAFR0C04470) KAFR_0I02020(KAFR0I02020)
PIC: PICST_81231(GSY1)
CAL: CAALFM_CR00780CA(GSY1)
CAUR: QG37_03063
SLB: AWJ20_4133(GSY1)
NCR: NCU06687(gsy-1)
NTE: NEUTE1DRAFT57176(NEUTE1DRAFT_57176)
MGR: MGG_07289
TRE: TRIREDRAFT_44529(gys1)
MAW: MAC_05928
MAJ: MAA_07866
CMT: CCM_03736
MBE: MBM_08435
ANI: AN8010.2
ANG: ANI_1_1448024(An02g10310)
ABE: ARB_06804
TVE: TRV_06758
PTE: PTT_15101
CNE: CNJ00590
CNB: CNBJ2910
ABP: AGABI1DRAFT77702(AGABI1DRAFT_77702)
ABV: AGABI2DRAFT212415(AGABI2DRAFT_212415)
DDI: DDB_G0267674(glcS)
DFA: DFA_00663(glcS)
DDS: Ddes_0468
DAS: Daes_2709
LIP: LI0332(glgP)
LIR: LAW_00344
SAT: SYN_00879
SSAN: NX02_00195
LPIL: LIP_1759
MTU: Rv3032
MTV: RVBD_3032
MTC: MT3116
MRA: MRA_3063
MTUR: CFBS_3199
MTD: UDA_3032
MTUC: J113_21130
MTUE: J114_16205
MTUL: TBHG_02961
MTUT: HKBT1_3186
MTUU: HKBT2_3191
MBB: BCG_3055
MBT: JTY_3050
MBX: BCGT_2878
MAF: MAF_30390
MMIC: RN08_3342
MLE: ML1715
MLB: MLBr01715
MPA: MAP_3064
MAO: MAP4_0736
MAVI: RC58_03590
MAVU: RE97_03595
MAV: MAV_3879
MAVD: NF84_17700
MAVR: LA63_17880
MAVA: LA64_17870
MIT: OCO_37000
MIA: OCU_37080
MIR: OCQ_38210
MID: MIP_05606
MYO: OEM_37660
MVA: Mvan_2096
MGI: Mflv_4262
MVQ: MYVA_1984
MUL: MUL_1919
MAB: MAB_3366
MABB: MASS_3307
MABO: NF82_16855
MCHE: BB28_16975
MSTE: MSTE_03333
MMC: Mmcs_1867
MKM: Mkms_1913
MJL: Mjls_1847
MMI: MMAR_1681
MMM: W7S_18520
MHAD: B586_15815
ASD: AS9A_3225
NFA: NFA_42820
RER: RER_23700
REY: O5Y_11105
ROP: ROP_65120
REQ: REQ_31760
RHB: NY08_1537
GBR: Gbro_3263
GOR: KTR9_3301
TPR: Tpau_2920
SRT: Srot_1400
IDO: I598_3217
SEN: SACE_6200
AMD: AMED_1646
AMN: RAM_08365
AMM: AMES_1634
AMZ: B737_1635
AOI: AORI_6275
PDX: Psed_1742
PSEA: WY02_10525
PSEE: FRP1_03730
PSEH: XF36_19100
AMI: Amir_6058
SESP: BN6_72610(gtuS4-14)
KAL: KALB_7484
ACAD: UA74_06385
ALL: CRK58937
MIL: ML5_4113
ACTN: L083_6171
CAI: Caci_3232
SNA: Snas_2349
CWO: Cwoe_4652
GLJ: GKIL_4397
AFD: Alfi_1237
CHU: CHU_1581(glgA)
DFE: Dfer_3735
SLI: Slin_5697
LBY: Lbys_2865
FAE: FAES_1227
HSW: Hsw_2975
FLM: MY04_1504(glgA)
COC: Coch_1285
MOX: DAMO_1068
NAA: Nps_00385
 » show all
Taxonomy
Reference
1  [PMID:13682402]
  Authors
ALGRANATI ID, CABIB E.
  Title
The synthesis of glycogen in yeast.
  Journal
Biochim. Biophys. Acta. 43 (1960) 141-2.
Reference
2  [PMID:13687710]
  Authors
BASU DK, BACHHAWAT BK.
  Title
Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain.
  Journal
Biochim. Biophys. Acta. 50 (1961) 123-8.
Reference
3
  Authors
Leloir, L.F. and Cardini, C.E.
  Title
UDPG-glycogen transglucosylase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 317-326.
Reference
4  [PMID:14415527]
  Authors
LELOIR LF, GOLDEMBERG SH.
  Title
Synthesis of glycogen from uridine diphosphate glucose in liver.
  Journal
J. Biol. Chem. 235 (1960) 919-23.
Reference
5  [PMID:2970965]
  Authors
Pitcher J, Smythe C, Cohen P.
  Title
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
  Journal
Eur. J. Biochem. 176 (1988) 391-5.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.11
IUBMB Enzyme Nomenclature: 2.4.1.11
ExPASy - ENZYME nomenclature database: 2.4.1.11
BRENDA, the Enzyme Database: 2.4.1.11
CAS: 9014-56-6

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