KEGG   ENZYME: 2.4.1.115Help
Entry
EC 2.4.1.115                Enzyme                                 

Name
anthocyanidin 3-O-glucosyltransferase;
uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase;
UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase;
UDP-glucose:cyanidin-3-O-glucosyltransferase;
UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase;
3-GT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase
Reaction(IUBMB)
UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside [RN:R03797]
Reaction(KEGG)
Substrate
UDP-D-glucose [CPD:C00029];
anthocyanidin [CPD:C02003]
Product
UDP [CPD:C00015];
anthocyanidin-3-O-beta-D-glucoside
Comment
The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.11.19, leucocyanidin oxygenase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].
History
EC 2.4.1.115 created 1984 (EC 2.4.1.233 created 2004, incorporated 2005), modified 2005
Pathway
Anthocyanin biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K12930  
anthocyanidin 3-O-glucosyltransferase
Genes
CIT: 
CIC: 
TCC: 
FVE: 
RCU: 
POP: 
VVI: 
100233099(UFGT)
Taxonomy
Reference
1  [PMID:751640]
  Authors
Kamsteeg J, van Brederode J, van Nigtevecht G.
  Title
Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).
  Journal
Biochem. Genet. 16 (1978) 1045-58.
Reference
2  [PMID:9535914]
  Authors
Ford CM, Boss PK, Hoj PB.
  Title
Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo.
  Journal
J. Biol. Chem. 273 (1998) 9224-33.
  Sequence
[vvi:100233099]
Reference
3  [PMID:11316805]
  Authors
Nakajima  J, Tanaka Y, Yamazaki M, Saito K.
  Title
Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis.
  Journal
J. Biol. Chem. 276 (2001) 25797-803.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65607-32-1

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