KEGG   ENZYME: 2.4.1.122Help
Entry
EC 2.4.1.122                Enzyme                                 

Name
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase;
uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase;
UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine [RN:R05908]
Reaction(KEGG)
R05908(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
glycoprotein N-acetyl-D-galactosamine
Product
UDP [CPD:C00015];
glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
Comment
The non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins can act as acceptors.
History
EC 2.4.1.122 created 1984
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K00731  
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
Genes
HSA: 
56913(C1GALT1)
PTR: 
472288(C1GALT1)
PPS: 
GGO: 
101145951(C1GALT1)
PON: 
100452461(C1GALT1)
MCC: 
696870(C1GALT1)
MCF: 
102137839(C1GALT1)
MMU: 
94192(C1galt1)
RNO: 
65044(C1galt1)
CGE: 
100761169(C1galt1)
HGL: 
TUP: 
102479007(C1GALT1)
CFA: 
482314(C1GALT1)
AML: 
100483848(C1GALT1)
FCA: 
101096459(C1GALT1)
PTG: 
102965358(C1GALT1)
BTA: 
539417(C1GALT1)
BOM: 
PHD: 
CHX: 
102169248(C1GALT1)
OAS: 
101120567(C1GALT1)
SSC: 
100525767(C1GALT1)
CFR: 
102514986(C1GALT1)
BACU: 
103001219(C1GALT1)
LVE: 
103071088(C1GALT1)
ECB: 
100063865(C1GALT1)
MYB: 
MYD: 
102754234(C1GALT1)
PALE: 
102883390(C1GALT1)
SHR: 
100932643(C1GALT1)
OAA: 
GGA: 
420575(C1GALT1)
MGP: 
TGU: 
100221974(C1GALT1)
FAB: 
PHI: 
APLA: 
101797632(C1GALT1)
FPG: 
101923797(C1GALT1)
FCH: 
102059381(C1GALT1)
CLV: 
102088254(C1GALT1)
ASN: 
AMJ: 
PSS: 
102460792(C1GALT1)
CMY: 
ACS: 
PBI: 
XLA: 
444326(c1galt1)
XTR: 
DRE: 
337131(c1galt1b) 555344 557675(c1galt1a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG9520(C1GalTA)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409263(GB18554)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_C38H2.2(C38H2.2)
CBR: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
OTA: 
MBR: 
TPS: 
PIF: 
NGD: 
NGA_0449900(C1GALT1)
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:6789880]
  Authors
Hesford FJ, Berger EG, Van den Eijnden DH.
  Title
Identification of the product formed by human erythrocyte galactosyltransferase.
  Journal
Biochim. Biophys. Acta. 659 (1981) 302-11.
Reference
2  [PMID:6801057]
  Authors
Mendicino J, Sivakami S, Davila M, Chandrasekaran EV.
  Title
Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa.
  Journal
J. Biol. Chem. 257 (1982) 3987-94.
Reference
3  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-61-7

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