KEGG   ENZYME: 2.4.1.133Help
Entry
EC 2.4.1.133                Enzyme                                 
Name
xylosylprotein 4-beta-galactosyltransferase;
UDP-D-galactose:D-xylose galactosyltransferase;
UDP-D-galactose:xylose galactosyltransferase;
galactosyltransferase I;
uridine diphosphogalactose-xylose galactosyltransferase;
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:O-beta-D-xylosyl-[protein] 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein] = UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] [RN:R05926]
Reaction(KEGG)
R05926(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
O-beta-D-xylosyl-[protein]
Product
UDP [CPD:C00015];
4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways
Orthology
K00733  
xylosylprotein 4-beta-galactosyltransferase
Genes
HSA: 
11285(B4GALT7)
PTR: 
664711(B4GALT7)
PPS: 
100969443(B4GALT7)
PON: 
100438606(B4GALT7)
MCC: 
701000(B4GALT7)
MMU: 
218271(B4galt7)
RNO: 
364675(B4galt7)
CFA: 
481445(B4GALT7)
AML: 
FCA: 
101099172(B4GALT7)
BTA: 
507559(B4GALT7)
SSC: 
100316855(B4GALT7)
ECB: 
100058225
MDO: 
100027902
SHR: 
100922950(B4GALT7)
OAA: 
100088745
GGA: 
416359(B4GALT7)
TGU: 
100217536
ACS: 
100556890
XLA: 
495369(b4galt7)
XTR: 
100144979(b4galt7)
DRE: 
445022(b4galt7)
TRU: 
778009(b4gal-t7)
OLA: 
100049391(b4gal-t7)
BFO: 
BRAFLDRAFT_124266
CIN: 
779002(b4gal-t7)
SPU: 
100893036
DME: 
Dmel_CG11780(beta4GalT7)
DPO: 
Dpse_GA11195
DAN: 
Dana_GF16319(Dana_beta4GalT7)
DER: 
Dere_GG11346(Dere_beta4GalT7)
DSE: 
Dsec_GM17784(Dsec_beta4GalT7)
DSI: 
Dsim_GD21157(Dsim_beta4GalT7)
DWI: 
Dwil_GK14189
DYA: 
Dyak_GE23542(Dyak_beta4GalT7)
DGR: 
Dgri_GH22239
DMO: 
Dmoj_GI22222(Dmoj_beta4GalT7)
DVI: 
Dvir_GJ24343
AAG: 
AaeL_AAEL007895
CQU: 
CpipJ_CPIJ015322
AME: 
551662(beta4GalT7)
NVI: 
100120002(NV17801)
TCA: 
662423
API: 
100159143
PHU: 
Phum_PHUM457130
ISC: 
IscW_ISCW003979
CEL: 
CELE_R10E11.4(sqv-3)
CBR: 
CBG09970(Cbr-sqv-3)
BMY: 
Bm1_44360
TSP: 
Tsp_04693
NVE: 
NEMVE_v1g82559
HMG: 
100206713
TAD: 
TRIADDRAFT_61457
AQU: 
100633202
 » show all
Taxonomy
Reference
1  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J. Biol. Chem. 250 (1975) 5200-7.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:10438455]
  Authors
Okajima T, Yoshida K, Kondo T, Furukawa K.
  Title
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
  Journal
J. Biol. Chem. 274 (1999) 22915-8.
  Organism
Homo sapiens [GN:hsa], Caenorhabditis elegans [GN:cel]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-72-2
DBGET integrated database retrieval system