KEGG   ENZYME: 2.4.1.133Help
Entry
EC 2.4.1.133                Enzyme                                 

Name
xylosylprotein 4-beta-galactosyltransferase;
UDP-D-galactose:D-xylose galactosyltransferase;
UDP-D-galactose:xylose galactosyltransferase;
galactosyltransferase I;
uridine diphosphogalactose-xylose galactosyltransferase;
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:O-beta-D-xylosyl-[protein] 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein] = UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] [RN:R05926]
Reaction(KEGG)
R05926(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
O-beta-D-xylosyl-[protein]
Product
UDP [CPD:C00015];
4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.133 created 1984, modified 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways
Orthology
K00733  
xylosylprotein 4-beta-galactosyltransferase
Genes
HSA: 
11285(B4GALT7)
PTR: 
664711(B4GALT7)
PPS: 
100969443(B4GALT7)
PON: 
100438606(B4GALT7)
MCC: 
701000(B4GALT7)
MCF: 
102134376(B4GALT7)
MMU: 
218271(B4galt7)
RNO: 
364675(B4galt7)
CGE: 
100769652(B4galt7)
HGL: 
101713013(B4galt7)
TUP: 
CFA: 
481445(B4GALT7)
AML: 
FCA: 
101099172(B4GALT7)
PTG: 
102949589(B4GALT7)
BTA: 
507559(B4GALT7)
BOM: 
102274604(B4GALT7)
PHD: 
102324782(B4GALT7)
CHX: 
102189205(B4GALT7)
OAS: 
100316848(B4GALT7)
SSC: 
100316855(B4GALT7)
CFR: 
102509297(B4GALT7)
BACU: 
102998185(B4GALT7)
LVE: 
103085357(B4GALT7)
ECB: 
100058225(B4GALT7)
MYB: 
102252387(B4GALT7)
MYD: 
102753871(B4GALT7)
PALE: 
102884700(B4GALT7)
MDO: 
100027902(B4GALT7)
SHR: 
100922950(B4GALT7)
OAA: 
100088745(B4GALT7)
GGA: 
416359(B4GALT7)
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
102455627(B4GALT7)
CMY: 
102946711(B4GALT7)
ACS: 
100556890(b4galt7)
PBI: 
103051226(B4GALT7)
XLA: 
495369(b4galt7)
XTR: 
100144979(b4galt7)
DRE: 
445022(b4galt7)
TRU: 
778009(b4gal-t7)
MZE: 
OLA: 
100049391(b4gal-t7)
XMA: 
LCM: 
BFO: 
CIN: 
779002(b4gal-t7)
SPU: 
DME: 
Dmel_CG11780(beta4GalT7)
DPO: 
DAN: 
Dana_GF16319(Dana_beta4GalT7)
DER: 
Dere_GG11346(Dere_beta4GalT7)
DSE: 
Dsec_GM17784(Dsec_beta4GalT7) Dsec_GM17785
DSI: 
Dsim_GD21157(Dsim_beta4GalT7)
DWI: 
DYA: 
Dyak_GE23542(Dyak_beta4GalT7)
DGR: 
DMO: 
Dmoj_GI22222(Dmoj_beta4GalT7)
DVI: 
AAG: 
CQU: 
AME: 
551662(beta4GalT7)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG09970(Cbr-sqv-3)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
TAD: 
AQU: 
MIS: 
MPP: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J. Biol. Chem. 250 (1975) 5200-7.
Reference
2  [PMID:10438455]
  Authors
Okajima T, Yoshida K, Kondo T, Furukawa K.
  Title
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
  Journal
J. Biol. Chem. 274 (1999) 22915-8.
  Sequence
[hsa:11285]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-72-2

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