| Entry |
|
|---|
| Name |
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein
3-beta-D-galactosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP +
3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
[RN:R05927] |
|---|
| Reaction(KEGG) |
R05927(G)
 |
|---|
| Substrate |
UDP-galactose [CPD:C00052];
4-beta-D-galactosyl-O-beta-D-xylosylprotein |
|---|
| Product |
UDP [CPD:C00015];
3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
[CPD:C04825] |
|---|
| Cofactor |
Manganese [CPD:C00034] |
|---|
| Comment |
Involved in the biosynthesis of the linkage region of
glycosaminoglycan chains as part of proteoglycan biosynthesis
(chondroitin, dermatan and heparan sulfates). Requires Mn2+. |
|---|
| Pathway |
PATH: ec00532 Chondroitin sulfate biosynthesis
PATH: ec00534 Heparan sulfate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00734 galactosylxylosylprotein 3-beta-galactosyltransferase |
|---|
| Genes |
HSA: 126792(B3GALT6)
PTR: 457187(B3GALT6)
MMU: 117592(B3galt6)
RNO: 298690(B3galt6)
CFA: 664717(B3GALT6)
BTA: 522406(B3GALT6)
ECB: 100146417
MDO: 100024991
GGA: 428185(B3GALT6)
TGU: 100225099
XTR: 548849
DRE: 572324
CIN: 778996(b3galt6)
SPU: 753784
AME: 552538
CEL: Y110A2AL.14(sqv-2)
NVE: NEMVE_v1g175792
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3924029]
Robinson JA, Robinson HC.
Initiation of chondroitin sulphate synthesis by beta-D-galactosides.
Substrates for galactosyltransferase II.
Biochem. J. 227 (1985) 805-14.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1150655]
Schwartz NB, Roden L.
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin
sulfate glycosyltransferases and partial purification of uridine
diphosphate-D-galactose:D-xylose galactosyltrans.
J. Biol. Chem. 250 (1975) 5200-7.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:11551958]
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD.
Biosynthesis of the linkage region of glycosaminoglycans: cloning
and activity of galactosyltransferase II, the sixth member of the
beta 1,3-galactosyltransferase family (beta 3GalT6).
J. Biol. Chem. 276 (2001) 48189-95.
Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Drosophila
melanogaster [GN:dme], Caenorhabditis elegans [GN:cel] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.134
IUBMB Enzyme Nomenclature: 2.4.1.134
ExPASy - ENZYME nomenclature database: 2.4.1.134
BRENDA, the Enzyme Database: 2.4.1.134
CAS: 56626-21-2 56626-19-8 |
|---|
