KEGG   ENZYME: 2.4.1.134Help
Entry
EC 2.4.1.134                Enzyme                                 

Name
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] [RN:R05927]
Reaction(KEGG)
R05927(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
Product
UDP [CPD:C00015];
3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.134 created 1984, modified 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways
Orthology
K00734  
galactosylxylosylprotein 3-beta-galactosyltransferase
Genes
HSA: 
126792(B3GALT6)
PTR: 
457187(B3GALT6)
PPS: 
100971409(B3GALT6)
MCC: 
MCF: 
102115188(B3GALT6)
MMU: 
117592(B3galt6)
RNO: 
298690(B3galt6)
CGE: 
HGL: 
101721217(B3galt6)
TUP: 
102502785(B3GALT6)
CFA: 
664717(B3GALT6)
AML: 
FCA: 
BTA: 
522406(B3GALT6)
BOM: 
102265005(B3GALT6)
PHD: 
102320877(B3GALT6)
CHX: 
102191357(B3GALT6)
SSC: 
100523125(B3GALT6)
CFR: 
102522264(B3GALT6)
ECB: 
100146417(B3GALT6)
MDO: 
GGA: 
428185(B3GALT6)
TGU: 
100225099(B3GALT6)
FAB: 
101808759(B3GALT6)
PHI: 
102108353(B3GALT6)
APLA: 
101798225(B3GALT6)
FPG: 
101913380(B3GALT6)
FCH: 
102056999(B3GALT6)
CLV: 
102096830(B3GALT6)
ASN: 
102373206(B3GALT6)
PSS: 
102452076(B3GALT6)
XTR: 
548849(b3galt6)
DRE: 
572324(b3galt6)
TRU: 
777996(b3galt6)
MZE: 
OLA: 
100049392(b3galt6)
XMA: 
LCM: 
BFO: 
CIN: 
778996(b3galt6)
SPU: 
DME: 
Dmel_CG8734(beta3GalTII)
DPO: 
Dpse_GA28758(Dpse_beta3galt6)
DAN: 
DER: 
Dere_GG10628(Dere_beta3galt6)
DPE: 
Dper_GL21178(Dper_beta3galt6)
DSE: 
Dsec_GM20673(Dsec_beta3galt6)
DWI: 
DYA: 
Dyak_GE22868(Dyak_beta3galt6)
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG19617(Cbr-sqv-2)
BMY: 
LOA: 
NVE: 
HMG: 
AQU: 
CSL: 
CVR: 
MBR: 
ACAN: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:3924029]
  Authors
Robinson JA, Robinson HC.
  Title
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.
  Journal
Biochem. J. 227 (1985) 805-14.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J. Biol. Chem. 250 (1975) 5200-7.
  Organism
Gallus gallus [GN:gga]
Reference
3  [PMID:11551958]
  Authors
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD.
  Title
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
  Journal
J. Biol. Chem. 276 (2001) 48189-95.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
  Sequence
[hsa:126792] [mmu:117592]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56626-21-2 56626-19-8

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