| Entry |
|
|---|
| Name |
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase;
glucuronosyltransferase I;
uridine diphosphate glucuronic acid:acceptor
glucuronosyltransferase;
UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-
xylosyl-protein D-glucuronosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xyl
osylprotein D-glucuronosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-glucuronate +
3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein =
UDP +
3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-
beta-D-xylosylprotein [RN:R04607 R05928] |
|---|
| Reaction(KEGG) |
R04607 R05928(G)
 |
|---|
| Substrate |
UDP-glucuronate [CPD:C00167];
3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
[CPD:C04825] |
|---|
| Product |
UDP [CPD:C00015];
3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-
beta-D-xylosylprotein [CPD:C04903] |
|---|
| Cofactor |
Manganese [CPD:C00034] |
|---|
| Comment |
Involved in the biosynthesis of the linkage region of
glycosaminoglycan chains as part of proteoglycan biosynthesis
(chondroitin, dermatan and heparan sulfates). Requires Mn2+. |
|---|
| Pathway |
PATH: ec00532 Chondroitin sulfate biosynthesis
PATH: ec00534 Heparan sulfate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00735 galactosylgalactosylxylosylprotein
3-beta-glucuronosyltransferase 1
KO: K10157 galactosylgalactosylxylosylprotein
3-beta-glucuronosyltransferase 2
KO: K10158 galactosylgalactosylxylosylprotein
3-beta-glucuronosyltransferase 3
KO: K10812 galactosylgalactosylxylosylprotein
3-beta-glucuronosyltransferase |
|---|
| Genes |
HSA: 135152(B3GAT2) 26229(B3GAT3) 27087(B3GAT1)
PTR: 462813(B3GAT2) 466859(B3GAT1) 641458(B3GAT3)
MCC: 695293(B3GAT1) 718744
MMU: 280645(B3gat2) 72727(B3gat3) 76898(B3gat1)
RNO: 117108(B3gat1) 293722(B3gat3) 64544(B3gat2)
CFA: 481875(B3GAT2) 483785(B3GAT3) 489265(B3GAT1)
BTA: 404162(B3GAT3) 541595(B3GAT2) 541596(B3GAT1)
ECB: 100063587 100072914
MDO: 100010236 100016092 100017866
OAA: 100090509
GGA: 373949(B3GAT1) 408180 428638(B3GAT2)
TGU: 100224397 100227480
XLA: 398597(b3gat3) 494776 733177(b3gat2)
XTR: 594895(b3gat3) 594896(b3gat1) 594928(b3gat2)
DRE: 192334(b3gat3) 445060(b3gat2) 548607 790914(b3gat3)
SPU: 579023
DME: Dmel_CG32775(GlcAT-I) Dmel_CG3881(GlcAT-S) Dmel_CG6207(GlcAT-P)
CEL: ZK1307.5(sqv-8)
NVE: NEMVE_v1g98778
 |
|---|
| Structures |
PDB: 1V82 1V83 1V84 2D0J 3CU0 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5770003]
Helting T, Roden L.
Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in
the formation of the carbohydrate-protein linkage region.
J. Biol. Chem. 244 (1969) 2799-805.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4260846]
Helting T.
Biosynthesis of heparin. Solubilization and partial purification of
uridine diphosphate glucuronic acid: acceptor
glucuronosyltransferase from mouse mastocytoma.
J. Biol. Chem. 247 (1972) 4327-32.
Mus musculus [GN:mmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9506957]
Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki
T, Sugahara K.
Molecular cloning and expression of glucuronyltransferase I involved
in the biosynthesis of the glycosaminoglycan-protein linkage region
of proteoglycans.
J. Biol. Chem. 273 (1998) 6615-8.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.135
IUBMB Enzyme Nomenclature: 2.4.1.135
ExPASy - ENZYME nomenclature database: 2.4.1.135
BRENDA, the Enzyme Database: 2.4.1.135
CAS: 227184-75-0 |
|---|
