| Entry |
|
|---|
| Name |
sucrose-phosphate synthase;
UDP-glucose---fructose-phosphate glucosyltransferase;
sucrosephosphate---UDP glucosyltransferase;
UDP-glucose-fructose-phosphate glucosyltransferase;
SPS;
uridine diphosphoglucose-fructose phosphate glucosyltransferase;
sucrose 6-phosphate synthase;
sucrose phosphate synthetase;
sucrose phosphate-uridine diphosphate glucosyltransferase;
sucrose phosphate synthase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6F-phosphate
[RN:R00766 R06073] |
|---|
| Reaction(KEGG) |
R00766 R06073(G)
 |
|---|
| Substrate |
UDP-glucose [CPD:C00029];
D-fructose 6-phosphate [CPD:C00085] |
|---|
| Product |
UDP [CPD:C00015];
sucrose 6F-phosphate [CPD:C02591] |
|---|
| Comment |
Requires Mg2+ or Mn2+ for maximal activity [2]. The enzyme from
Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as
it can use ADP-glucose and, to a lesser extent, GDP-glucose as
substrates [2]. The enzyme from rice leaves is activated by glucose
6-phosphate but that from cyanobacterial species is not [2]. While
the reaction catalysed by this enzyme is reversible, the enzyme
usually works in concert with EC 3.1.3.24, sucrose-phosphate
phosphatase, to form sucrose, making the above reaction essentially
irreversible [3]. The F in sucrose 6F-phosphate is used to indicate
that the fructose residue of sucrose carries the substituent. |
|---|
| Pathway |
PATH: ec00500 Starch and sucrose metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00696 sucrose-phosphate synthase |
|---|
| Genes |
ATH: AT1G04920 AT4G10120 AT5G20280
POP: POPTR_242863 POPTR_745684 POPTR_779065 POPTR_783315
POPTR_797985
RCU: RCOM_0271410 RCOM_0923320 RCOM_1018300 RCOM_1329250
VVI: 100232974 100241955(GSVIVT00006423001) 100262385
OSA: 4328527(Os02g0184400) 4345220(Os08g0301500)
SBI: SORBI_03g043900(SORBIDRAFT_03g043900)
SORBI_04g005720(SORBIDRAFT_04g005720)
SORBI_09g028570(SORBIDRAFT_09g028570)
ZMA: 542711(sps1)
PPP: PHYPADRAFT_210965
VSP: VS_1178
VSA: VSAL_I1623
TCX: Tcr_1794
NOC: Noc_3069
TGR: Tgr7_0708
HNA: Hneap_0227
AFE: Lferr_1267
AFR: AFE_1551
NEU: NE1213(sps)
NET: Neut_1080
NMU: Nmul_A2267
MFA: Mfla_2610
MEI: Msip34_2763
DBA: Dbac_2912
DOL: Dole_0650
DAT: HRM2_24290(spsA)
MEX: Mext_0200
MEA: Mex_1p0091
MDI: METDI0081
MPO: Mpop_0284
MCH: Mchl_0143
MGM: Mmc1_3516
HOR: Hore_18210
FJO: Fjoh_3967
RBA: RB5197(sps)
SYN: sll0045(sps)
SYW: SYNW2520(sps)
SYC: syc0730_d(sps)
SYF: Synpcc7942_0808
SYD: Syncc9605_2689
SYE: Syncc9902_2315
SYG: sync_2936
SYR: SynRCC307_2529(sps)
SYX: SynWH7803_2527
SYP: SYNPCC7002_A0888(spsA)
TEL: tlr0582(sps)
NPU: Npun_F4709
PMA: Pro1880(rfaG)
PMM: PMM1711(sps)
PMT: PMT2268(sps)
PMN: PMN2A_1322
PMI: PMT9312_1803
PMB: A9601_19201
PMC: P9515_19021
PMF: P9303_30171(sps)
PMG: P9301_19011
PMH: P9215_19831
PMJ: P9211_18491
PME: NATL1_21951(sps)
TME: Tmel_0533
TAF: THA_1341
FNO: Fnod_0446
PMO: Pmob_1867
KOL: Kole_1069
 |
|---|
| Structures |
PDB: 2R60 2R66 2R68 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13769376]
MENDICINO J.
Sucrose phosphate synthesis in wheat germ and green leaves.
J. Biol. Chem. 235 (1960) 3347-52.
Triticum aestivum, Spinacia oleracea |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:9852031]
Curatti L, Folco E, Desplats P, Abratti G, Limones V,
Herrera-Estrella L, Salerno G
Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803:
identification of the spsA gene and characterization of the enzyme
expressed in Escherichia coli.
J. Bacteriol. 180 (1998) 6776-9.
Synechocystis sp. [GN:syn] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:15012296]
Huber SC, Huber JL
ROLE AND REGULATION OF SUCROSE-PHOSPHATE SYNTHASE IN HIGHER PLANTS.
Annu. Rev. Plant. Physiol. Plant. Mol. Biol. 47 (1996) 431-444.
Zea mays [GN:zma], Spinacia oleracea |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:12062401]
Cumino A, Curatti L, Giarrocco L, Salerno GL
Sucrose metabolism: Anabaena sucrose-phosphate synthase and
sucrose-phosphate phosphatase define minimal functional domains
shuffled during evolution.
FEBS. Lett. 517 (2002) 19-23.
Anabaena sp. [GN:ana] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:18424616]
Chua TK, Bujnicki JM, Tan TC, Huynh F, Patel BK, Sivaraman J
The structure of sucrose phosphate synthase from Halothermothrix
orenii reveals its mechanism of action and binding mode.
Plant. Cell. 20 (2008) 1059-72.
Halothermothrix orenii [GN:hor] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.14
IUBMB Enzyme Nomenclature: 2.4.1.14
ExPASy - ENZYME nomenclature database: 2.4.1.14
BRENDA, the Enzyme Database: 2.4.1.14
CAS: 9030-06-2 |
|---|
