| Entry |
|
|---|
| Name |
alpha-1,6-mannosyl-glycoprotein
2-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase II;
N-glycosyl-oligosaccharide-glycoprotein
N-acetylglucosaminyltransferase II;
acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mannoside
alpha1->6-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein
beta-1-2-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-D-mannoside
beta1-2-acetylglucosaminyltransferase;
UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase;
alpha-1,6-mannosyl-glycoprotein
beta-1,2-N-acetylglucosaminyltransferase;
GnTII |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glyc
oprotein 2-beta-N-acetyl-D-glucosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R
= UDP +
6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-
mannosyl-R [RN:R07258] |
|---|
| Reaction(KEGG) |
R07258;
(other) R04653 R05985(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-glucosamine [CPD:C00043];
6-(alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C15543] |
|---|
| Product |
UDP [CPD:C00015];
6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-
mannosyl-R [CPD:C04944] |
|---|
| Comment |
R represents the remainder of the N-linked oligosaccharide in the
glycoprotein acceptor. Note that this enzyme acts after
N-acetylglucosaminyltransferase I but before
N-acetylglucosaminyltransferases III, IV, V and VI (click here for
diagram). |
|---|
| Pathway |
PATH: ec00510 N-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00736 alpha-1,6-mannosyl-glycoprotein
beta-1,2-N-acetylglucosaminyltransferase |
|---|
| Genes |
HSA: 4247(MGAT2)
PTR: 740608(MGAT2)
MMU: 217664(Mgat2)
RNO: 94273(Mgat2)
CFA: 480312(MGAT2)
BTA: 539918(MGAT2)
SSC: 100151745(MGAT2)
ECB: 100065740
MDO: 100023862
XLA: 414590
XTR: 448439(mgat2)
DRE: 100000478
BFO: BRAFLDRAFT_241527
SPU: 593053
DME: Dmel_CG7921(Mgat2)
DPO: Dpse_GA26865
DAN: Dana_GF16208
DER: Dere_GG11975
AGA: AgaP_AGAP004397
AAG: AaeL_AAEL005949
CQU: CpipJ_CPIJ003883
AME: 726476
NVI: 100115420
TCA: 658173
API: 100159651
CEL: C03E10.4(gly-20)
OSA: 4331021(Os02g0798100)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2952644]
Bendiak B, Schachter H.
Control of glycoprotein synthesis. Purification of
UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2
N-acetylglucosaminyltransferase II from rat liver.
J. Biol. Chem. 262 (1987) 5775-83.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6445358]
Harpaz N, Schachter H.
Control of glycoprotein synthesis. Bovine colostrum
UDP-N-acetylglucosamine:alpha-D-mannoside beta
2-N-acetylglucosaminyltransferase I. Separation from
UDP-N-acetylglucosamine:alpha-D-mannoside beta
2-N-acetylglucosaminyltransferase II, partial purification, and
substrate specificity.
J. Biol. Chem. 255 (1980) 4885-93.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6452163]
Mendicino J, Chandrasekaran EV, Anumula KR, Davila M.
Isolation and properties of
alpha-D-mannose:beta-1,2-N-acetylglucosaminyltransferase from
trachea mucosa.
Biochemistry. 20 (1981) 967-76.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6457827]
Oppenheimer CL, Eckhardt AE, Hill RL.
The nonidentity of porcine N-acetylglucosaminyltransferases I and
II.
J. Biol. Chem. 256 (1981) 11477-82.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
|
5 [PMID:6366476]
Schachter H, Narasimhan S, Gleeson P, Vella G.
Glycosyltransferases involved in elongation of N-glycosidically
linked oligosaccharides of the complex or N-acetyllactosamine type.
Methods. Enzymol. 98 (1983) 98-134. |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:2952644]
Bendiak B, Schachter H.
Control of glycoprotein synthesis. Purification of
UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2
N-acetylglucosaminyltransferase II from rat liver.
J. Biol. Chem. 262 (1987) 5775-83.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.143
IUBMB Enzyme Nomenclature: 2.4.1.143
ExPASy - ENZYME nomenclature database: 2.4.1.143
BRENDA, the Enzyme Database: 2.4.1.143
CAS: 105913-04-0 |
|---|
