KEGG   ENZYME: 2.4.1.143Help
Entry
EC 2.4.1.143                Enzyme                                 
Name
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase II;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase;
UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase;
alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase;
GnTII
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [RN:R07258]
Reaction(KEGG)
R07258;
(other) R04653 R05985(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
6-(alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C15543]
Product
UDP [CPD:C00015];
6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04944]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor. Note that this enzyme acts after N-acetylglucosaminyltransferase I but before N-acetylglucosaminyltransferases III, IV, V and VI (click here for diagram).
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K00736  
alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Genes
HSA: 
4247(MGAT2)
PTR: 
740608(MGAT2)
PPS: 
100985211(MGAT2)
GGO: 
101130348(MGAT2)
PON: 
100460559(MGAT2)
MMU: 
217664(Mgat2)
RNO: 
94273(Mgat2)
CFA: 
480312(MGAT2)
AML: 
100469937(MGAT2)
FCA: 
101092119(MGAT2)
SSC: 
100151745(MGAT2)
ECB: 
100065740
MDO: 
100023862(MGAT2)
SHR: 
100927464(MGAT2)
OAA: 
100084500
GGA: 
428925
MGP: 
100539456
XLA: 
414590(mgat2) 444674
XTR: 
448439(mgat2)
DRE: 
100000478(mgat2)
TRU: 
101063078
OLA: 
101165022
BFO: 
BRAFLDRAFT_241527
SPU: 
593053
DME: 
Dmel_CG7921(Mgat2)
DPO: 
Dpse_GA26865
DAN: 
Dana_GF16208
DER: 
Dere_GG11975
DPE: 
Dper_GL13486
DSE: 
Dsec_GM12193
DSI: 
Dsim_GD17443
DWI: 
Dwil_GK13428
DYA: 
Dyak_GE23425
DGR: 
Dgri_GH22139
DMO: 
Dmoj_GI18065 Dmoj_GI21962
DVI: 
Dvir_GJ14322
AGA: 
AgaP_AGAP004397
AAG: 
AaeL_AAEL005949
CQU: 
CpipJ_CPIJ003883 CpipJ_CPIJ003884
AME: 
726476(Mgat2)
NVI: 
100115420(NV13086)
TCA: 
658173
API: 
100159651
PHU: 
Phum_PHUM003200
ISC: 
IscW_ISCW014205 IscW_ISCW022527
CEL: 
CELE_C03E10.4(gly-20)
CBR: 
CBG23158(Cbr-gly-20)
BMY: 
Bm1_39220
TSP: 
Tsp_00241
SMM: 
Smp_089240
NVE: 
NEMVE_v1g239681
HMG: 
100199919
TAD: 
TRIADDRAFT_31240
ATH: 
AT2G05320
ALY: 
ARALYDRAFT_480143
GMX: 
100819421
CSV: 
101213679
RCU: 
RCOM_0347110
POP: 
POPTR_896156
VVI: 
100240895
OSA: 
4331021
DOSA: 
Os02t0798100-00(Os02g0798100)
BDI: 
100832652
SBI: 
SORBI_04g036090(SORBIDRAFT_04g036090)
ZMA: 
100381400
SMO: 
SELMODRAFT_80130(GntII)
PPP: 
PHYPADRAFT_113818 PHYPADRAFT_226628
 » show all
Taxonomy
Reference
1  [PMID:2952644]
  Authors
Bendiak B, Schachter H.
  Title
Control of glycoprotein synthesis. Purification of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2 N-acetylglucosaminyltransferase II from rat liver.
  Journal
J. Biol. Chem. 262 (1987) 5775-83.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:6445358]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase II, partial purification, and substrate specificity.
  Journal
J. Biol. Chem. 255 (1980) 4885-93.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:6452163]
  Authors
Mendicino J, Chandrasekaran EV, Anumula KR, Davila M.
  Title
Isolation and properties of alpha-D-mannose:beta-1,2-N-acetylglucosaminyltransferase from trachea mucosa.
  Journal
Biochemistry. 20 (1981) 967-76.
  Organism
Sus scofa [GN:ssc]
Reference
4  [PMID:6457827]
  Authors
Oppenheimer CL, Eckhardt AE, Hill RL.
  Title
The nonidentity of porcine N-acetylglucosaminyltransferases I and II.
  Journal
J. Biol. Chem. 256 (1981) 11477-82.
  Organism
Sus scofa [GN:ssc]
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Reference
6  [PMID:2952644]
  Authors
Bendiak B, Schachter H.
  Title
Control of glycoprotein synthesis. Purification of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2 N-acetylglucosaminyltransferase II from rat liver.
  Journal
J. Biol. Chem. 262 (1987) 5775-83.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
105913-04-0
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