KEGG   ENZYME: 2.4.1.144Help
Entry
EC 2.4.1.144                Enzyme                                 

Name
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase III;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III;
beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTIII
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [RN:R07259]
Reaction(KEGG)
R07259;
(other) R05986(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-mannosyl-R [CPD:C04942]
Product
UDP [CPD:C00015];
4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [CPD:C15544]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram). The action of this enzyme probably prevents further attachment of N-acetylglucosamine residues to the growing carbohydrate chain.
History
EC 2.4.1.144 created 1984, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984)
Pathway
N-Glycan biosynthesis
Metabolic pathways
Orthology
K00737  
beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Genes
HSA: 
4248(MGAT3)
PTR: 
470218(MGAT3)
PPS: 
100986687(MGAT3)
GGO: 
101140166(MGAT3)
PON: 
100461728(MGAT3)
MCC: 
703643(MGAT3)
MCF: 
102119319(MGAT3)
MMU: 
17309(Mgat3)
RNO: 
29582(Mgat3)
CGE: 
100689076(Mgat3)
HGL: 
101726123(Mgat3)
TUP: 
102479156(MGAT3)
CFA: 
481244(MGAT3)
AML: 
FCA: 
101096819(MGAT3)
PTG: 
102951185(MGAT3)
BTA: 
520087(MGAT3)
BOM: 
102272014(MGAT3)
PHD: 
102326943(MGAT3)
CHX: 
102185445(MGAT3)
SSC: 
100625969(MGAT3)
CFR: 
102511595(MGAT3)
BACU: 
103016283(MGAT3)
LVE: 
103083856(MGAT3)
ECB: 
100055333(MGAT3)
MYB: 
102245140(MGAT3)
MYD: 
102751860(MGAT3)
PALE: 
102897210(MGAT3)
MDO: 
100012345(MGAT3)
SHR: 
100917350(MGAT3)
OAA: 
100090777(MGAT3)
GGA: 
418013(MGAT3)
MGP: 
TGU: 
100226352(MGAT3)
FAB: 
101814927(MGAT3)
PHI: 
102100315(MGAT3)
APLA: 
101794219(MGAT3)
FPG: 
101921320(MGAT3)
FCH: 
102048799(MGAT3)
CLV: 
102093513(MGAT3)
ASN: 
102370976(MGAT3)
AMJ: 
102563722(MGAT3)
PSS: 
102450203(MGAT3)
CMY: 
102941302(MGAT3)
ACS: 
PBI: 
103058421(MGAT3)
XTR: 
100492491(mgat3)
DRE: 
553676(mgat3a) 570828
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103172616(mgat3)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
PHU: 
ISC: 
NVE: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0001s35510g POPTR_0006s06560g POPTR_0008s19000g(POPTRDRAFT_1085621) POPTR_0010s05700g(POPTRDRAFT_230496) POPTR_0018s12800g(POPTRDRAFT_578921)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0594900-01(Os02g0594900) Os02t0595100-01(Os02g0595100) Os04t0477500-01(Os04g0477500) Os12t0611900-01(Os12g0611900)
OBR: 
BDI: 
SBI: 
SORBI_04g024790(SORBIDRAFT_04g024790) SORBI_06g020110(SORBIDRAFT_06g020110) SORBI_08g021190(SORBIDRAFT_08g021190)
ZMA: 
SITA: 
ATR: 
s00049p00218400(AMTR_s00049p00218400) s00092p00122190(AMTR_s00092p00122190)
SMO: 
PPP: 
OLU: 
MPP: 
CSL: 
GSL: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
ELA: 
SSL: 
BFU: 
MBE: 
AJE: 
ZTR: 
PFJ: 
BCOM: 
LBC: 
MPR: 
SCM: 
ACAN: 
NGD: 
GTT: 
ENC: 
ECLO: 
EEC: 
EAU: 
MPC: 
BMU: 
BMJ: 
BGD: 
PNU: 
PNE: 
BBA: 
BBAT: 
BBAC: 
PSF: 
RCE: 
ABS: 
TMO: 
PGV: 
APM: 
BPB: 
SSG: 
SRI: 
TPX: 
 » show all
Taxonomy
Reference
1  [PMID:6213618]
  Authors
Narasimhan S.
  Title
Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides.
  Journal
J. Biol. Chem. 257 (1982) 10235-42.
  Organism
Gallus gallus
Reference
2  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83744-93-8

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