| Entry |
|
|---|
| Name |
beta-1,4-mannosyl-glycoprotein
4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase III;
N-glycosyl-oligosaccharide-glycoprotein
N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-glycopeptide
beta4-acetylglucosaminyltransferase III;
beta-1,4-mannosyl-glycoprotein
beta-1,4-N-acetylglucosaminyltransferase;
GnTIII |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein
4-beta-N-acetyl-D-glucosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP +
4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [RN:R07259] |
|---|
| Reaction(KEGG) |
R07259;
(other) R05986(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-mannosyl-R [CPD:C04942] |
|---|
| Product |
UDP [CPD:C00015];
4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R [CPD:C15544] |
|---|
| Comment |
R represents the remainder of the N-linked oligosaccharide in the
glycoprotein acceptor (click here for diagram). The action of this
enzyme probably prevents further attachment of N-acetylglucosamine
residues to the growing carbohydrate chain. |
|---|
| Pathway |
PATH: ec00510 N-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00737 beta-1,4-mannosyl-glycoprotein
beta-1,4-N-acetylglucosaminyltransferase |
|---|
| Genes |
HSA: 4248(MGAT3)
PTR: 470218(MGAT3)
MCC: 703643(MGAT3)
MMU: 17309(Mgat3)
RNO: 29582(Mgat3)
CFA: 481244(MGAT3)
BTA: 520087(MGAT3)
ECB: 100055333(MGAT3)
MDO: 100012345
OAA: 100090777
GGA: 418013(MGAT3)
TGU: 100226352
DRE: 570828
NVE: NEMVE_v1g217354
OLU: OSTLU_18822
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6213618]
Narasimhan S.
Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta
4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct
which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of
the trimannosyl core of N-glycosyl oligosaccharides.
J. Biol. Chem. 257 (1982) 10235-42.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:6366476]
Schachter H, Narasimhan S, Gleeson P, Vella G.
Glycosyltransferases involved in elongation of N-glycosidically
linked oligosaccharides of the complex or N-acetyllactosamine type.
Methods. Enzymol. 98 (1983) 98-134. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.144
IUBMB Enzyme Nomenclature: 2.4.1.144
ExPASy - ENZYME nomenclature database: 2.4.1.144
BRENDA, the Enzyme Database: 2.4.1.144
CAS: 83744-93-8 |
|---|
