KEGG   ENZYME: 2.4.1.145Help
Entry
EC 2.4.1.145                Enzyme                                 

Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase IV;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV;
beta-acetylglucosaminyltransferase IV;
uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV;
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTIV
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [RN:R04662]
Reaction(KEGG)
R04662;
(other) R05987(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04880]
Product
UDP [CPD:C00015];
3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04943]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram). The best acceptor for this enzyme is probably the same as that favoured by EC 2.4.1.144, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
History
EC 2.4.1.145 created 1984, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984)
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K00738  
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B
K13748  
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C
Genes
HSA: 
11282(MGAT4B) 11320(MGAT4A) 152586(MGAT4D) 25834(MGAT4C)
PTR: 
459434(MGAT4A) 461502 467085(MGAT4C) 471774(MGAT4B)
PPS: 
100981022(MGAT4B) 100992134(MGAT4C) 100994401 100996009(MGAT4A)
GGO: 
101141983 101143539(MGAT4A) 101148891(MGAT4B) 101151757(MGAT4C)
PON: 
100190826(MGAT4A) 100455323(MGAT4C) 100457326(MGAT4B) 100938596
MCC: 
700450 701630 705006(MGAT4B) 708094(MGAT4A)
MCF: 
101866133(MGAT4A) 101866242(MGAT4C) 102143163(MGAT4B) 102146807
MMU: 
103534(Mgat4b) 269181(Mgat4a) 67555(4933434I20Rik) 67569(Mgat4c)
RNO: 
102554921 299756(Mgat4c) 303100(Mgat4b) 304646(RGD1310572) 367252(Mgat4a)
CGE: 
100760589(Mgat4c) 100766200(Mgat4a) 100768637(Mgat4b) 100774333
HGL: 
TUP: 
102467784(MGAT4C) 102475912(MGAT4A) 102480932 102484580(MGAT4B)
CFA: 
102153780 474562(MGAT4A) 475418(MGAT4C) 481458(MGAT4B)
AML: 
100465193(MGAT4C) 100469508 100481251(MGAT4A)
FCA: 
101088153(MGAT4A) 101095945(MGAT4B) 101096077(MGAT4C) 102900578
PTG: 
102953882(MGAT4B) 102962178 102966537(MGAT4A) 102971513(MGAT4C)
BTA: 
101907024 282276(MGAT4A) 526256(MGAT4B) 539661(MGAT4C)
BOM: 
PHD: 
102316698(MGAT4B) 102325642(MGAT4C) 102337122 102340515(MGAT4A)
CHX: 
OAS: 
101105106 101108733(MGAT4C) 101108820(MGAT4A) 101119044(MGAT4B)
SSC: 
100512242 100521073(MGAT4B) 100524079(MGAT4A) 414851(MGAT4C)
CFR: 
102503643 102503714(MGAT4C) 102506006(MGAT4B) 102522357(MGAT4A)
BACU: 
103004161(MGAT4C) 103010086(MGAT4A) 103011292(MGAT4B) 103018629
LVE: 
103075784(MGAT4A) 103080459(MGAT4C) 103086020(MGAT4B)
ECB: 
100050964(MGAT4A) 100051064(MGAT4C) 100067257(MGAT4B) 102147352
MYB: 
MYD: 
102760456 102762292(MGAT4A) 102769462(MGAT4C) 102770440(MGAT4B)
PALE: 
102882602(MGAT4C) 102882798(MGAT4A) 102891025 102891973(MGAT4B)
MDO: 
100013784(MGAT4A) 100020942(MGAT4C) 100027218 100028175(MGAT4B)
SHR: 
100916939 100920029(MGAT4A) 100932381(MGAT4C) 100933355(MGAT4B)
OAA: 
100081053(MGAT4C) 100081934 100093525(MGAT4A)
GGA: 
395415(MGAT4C) 416285(MGAT4B) 418692(MGAT4A) 422448 427873(MGAT4C)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
443870(mgat4b) 734354(mgat4a)
XTR: 
100124983(mgat4b) 100145594(mgat4a) 100486336(mgat4c) 100489322
DRE: 
100333333 431727(mgat4b) 563038(mgat4a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412423(GB10809)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
TAD: 
MBR: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:6222042]
  Authors
Gleeson PA, Schachter H.
  Title
Control of glycoprotein synthesis.
  Journal
J. Biol. Chem. 258 (1983) 6162-73.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
86498-16-0

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