KEGG   ENZYME: 2.4.1.147Help
Entry
EC 2.4.1.147                Enzyme                                 
Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase;
mucin core 3 beta3-GlcNAc-transferase;
Core 3beta-GlcNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R [RN:R03513]
Reaction(KEGG)
R03513;
(other) R05909(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
N-acetyl-beta-D-galactosaminyl-R [CPD:C04135]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
Comment
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K00739  
acetylgalactosaminyl-0-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA: 
192134(B3GNT6)
PTR: 
451437(B3GNT6)
PPS: 
100976514(B3GNT6)
GGO: 
101135837(B3GNT6)
PON: 
100447110(B3GNT6)
MCC: 
697946(B3GNT6)
MMU: 
272411(B3gnt6)
RNO: 
292325(B3gnt6)
CFA: 
485176(B3GNT6)
AML: 
FCA: 
101088357(B3GNT6)
BTA: 
540848(B3GNT6) 786615(B3GNT6)
SSC: 
100524328
ECB: 
100146508
 » show all
Taxonomy
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr. Res. 120 (1983) 3-16.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
87927-96-6
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