KEGG   ENZYME: 2.4.1.147Help
Entry
EC 2.4.1.147                Enzyme                                 

Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase;
mucin core 3 beta3-GlcNAc-transferase;
Core 3beta-GlcNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] = UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] [RN:R05909]
Reaction(KEGG)
R05909(G);
(other) R03513
Show
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Product
UDP [CPD:C00015];
O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Comment
The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
History
EC 2.4.1.147 created 1984, modified 2015
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K00739  
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA: 
192134(B3GNT6)
PTR: 
451437(B3GNT6)
PPS: 
100976514(B3GNT6)
GGO: 
101135837(B3GNT6)
PON: 
100447110(B3GNT6)
NLE: 
100590559(B3GNT6)
MCC: 
697946(B3GNT6)
MCF: 
102140679(B3GNT6)
RRO: 
104665081(B3GNT6)
CJC: 
100395512(B3GNT6)
MMU: 
272411(B3gnt6)
RNO: 
292325(B3gnt6)
CGE: 
100768656(B3gnt6)
NGI: 
103743061(B3gnt6)
HGL: 
101709961(B3gnt6)
OCU: 
100351306(B3GNT6)
TUP: 
102471967(B3GNT6)
CFA: 
485176(B3GNT6)
AML: 
100477436(B3GNT6)
FCA: 
101088357(B3GNT6)
BTA: 
540848(B3GNT6)
BOM: 
102281875(B3GNT6)
PHD: 
102343067(B3GNT6)
CHX: 
102177179(B3GNT6)
OAS: 
101110268(B3GNT6)
SSC: 
100524328(B3GNT6)
CFR: 
102514253(B3GNT6)
BACU: 
103008870(B3GNT6)
LVE: 
103070939(B3GNT6)
ECB: 
100146508(B3GNT6)
 » show all
Taxonomy
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr. Res. 120 (1983) 3-16.
Reference
2  [PMID:3160388]
  Authors
Brockhausen I, Matta KL, Orr J, Schachter H
  Title
Mucin synthesis. UDP-GlcNAc:GalNAc-R beta 3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from pig and rat colon mucosa.
  Journal
Biochemistry. 24 (1985) 1866-74.
Reference
3  [PMID:7655172]
  Authors
Vavasseur F, Yang JM, Dole K, Paulsen H, Brockhausen I
  Title
Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines.
  Journal
Glycobiology. 5 (1995) 351-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
87927-96-6

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