KEGG   ENZYME: 2.4.1.149Help
Entry
EC 2.4.1.149                Enzyme                                 

Name
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase;
poly-N-acetyllactosamine extension enzyme;
Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase;
UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase;
N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase;
UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-acetylglucosaminyltransferase;
GnTE;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [RN:R02789]
Reaction(KEGG)
R02789 > R05974(G) R05975(G);
(other) R04659
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C00694]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C04890]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and other glycoproteins and oligosaccharides.
History
EC 2.4.1.149 created 1984
Pathway
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00741  
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA: 
10678(B3GNT2) 11041(B3GNT1)
PTR: 
451344(B3GNT1) 745838(B3GNT2)
PPS: 
100969129(B3GNT1) 100973625(B3GNT2)
GGO: 
101130700(B3GNT2) 101144764(B3GNT1)
PON: 
NLE: 
100593252(B3GNT2) 100607325(B3GNT2)
MCC: 
693396(B3GNT2) 714270(B3GNT1)
MCF: 
CJC: 
100385332 100396330(B3GNT1) 100407247(B3GNT2)
MMU: 
108902(B3gnt1) 53625(B3gnt2)
RNO: 
100911750 293667(B3gnt1) 305571(B3gnt2)
CGE: 
100762253(B3gnt1) 100766691(B3gnt2)
NGI: 
103725028(B3gnt1) 103743255(B3gnt2)
HGL: 
101723595(B3gnt2) 101724680(B3gnt1) 101728658
OCU: 
100342947(B3GNT2) 100355603(B3GNT1)
TUP: 
102471847(B3GNT2) 102495897(B3GNT1)
CFA: 
474611(B3GNT2) 476013(B3GNT1)
AML: 
UMR: 
103671308(B3GNT2) 103679492(B3GNT1)
FCA: 
101080523(B3GNT2) 101084574(B3GNT1)
PTG: 
102953748(B3GNT2) 102965050(B3GNT1)
BTA: 
515585(B3GNT2) 618055(B3GNT1)
BOM: 
PHD: 
102325600(B3GNT1) 102337098(B3GNT2)
CHX: 
102172908(B3GNT2) 102175929(B3GNT1)
OAS: 
101105702(B3GNT1) 101117403(B3GNT2)
SSC: 
100518412(B3GNT1) 100524195(B3GNT2) 100623864
CFR: 
102506509(B3GNT2) 102509238(B3GNT1)
BACU: 
103006629(B3GNT1) 103013589(B3GNT2) 103018714
LVE: 
103077012(B3GNT1) 103079240(B3GNT2)
ECB: 
100058396(B3GNT1) 100064405(B3GNT2)
MYB: 
MYD: 
102754559(B3GNT1) 102762333(B3GNT2)
PALE: 
102879580(B3GNT1) 102879999(B3GNT2)
MDO: 
100029667(B3GNT1) 100031891(B3GNT2)
SHR: 
100928418(B3GNT2) 100928923(B3GNT1)
OAA: 
100078191(B3GNT2) 100086023(B3GNT1)
GGA: 
421286(B3GNT2)
MGP: 
APLA: 
101793948(B3GNT2)
TGU: 
FAB: 
101811829(B3GNT2)
PHI: 
102107608(B3GNT2) 102111308(B3GNT1)
FPG: 
101910333(B3GNT2)
FCH: 
102047111(B3GNT2)
CLV: 
102085751(B3GNT2)
ASN: 
AMJ: 
102559888(B3GNT1) 102573235(B3GNT2)
PSS: 
102453435(B3GNT1) 102453681 102460724(B3GNT2)
CMY: 
ACS: 
100554272(b3gnt2) 100563251(b3gnt1)
PBI: 
103048729 103052938(B3GNT2) 103060672(B3GNT1)
XLA: 
414647(b3gnt2)
XTR: 
100170561(b3gnt2) 100170600(b3gnt1)
DRE: 
101669768(b3gnt1) 793362(b3gnt2b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352330(B3GNT1) 102354201 102359554(B3GNT2)
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410005(GB19259)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
HRO: 
LGI: 
NVE: 
TAD: 
DSQ: 
PCO: 
MBR: 
 » show all
Taxonomy
Reference
1  [PMID:3160874]
  Authors
Takeya A, Hosomi O, Kogure T.
  Title
The presence of N-acetyllactosamine and lactose: beta (1-3)N-acetylglucosaminyltransferase activity in human urine.
  Journal
Jpn. J. Med. Sci. Biol. 38 (1985) 1-8.
Reference
2  [PMID:6219989]
  Authors
van den Eijnden DH, Winterwerp H, Smeeman P, Schiphorst WE.
  Title
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.
  Journal
J. Biol. Chem. 258 (1983) 3435-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85638-39-7

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