KEGG   ENZYME: 2.4.1.150Help
Entry
EC 2.4.1.150                Enzyme                                 
Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase;
N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase;
Galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase;
UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferasel UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminide 6-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [RN:R02790]
Reaction(KEGG)
R02790;
(other) R06189(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C00694]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C04891]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein.
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00742  
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
Genes
HSA: 
2651(GCNT2)
PTR: 
PPS: 
GGO: 
PON: 
100173016(GCNT2)
MCC: 
697356 697468(GCNT2)
MMU: 
14538(Gcnt2)
RNO: 
306860(Gcnt2)
CFA: 
488214 488215(GCNT2)
AML: 
FCA: 
101094925
BTA: 
100848875 100850229 520336(GCNT2)
SSC: 
100152566(GCNT2) 100738362
ECB: 
100063202 100063291(GCNT2)
MDO: 
100027080
SHR: 
100925756
OAA: 
100084006 100084044
GGA: 
420861(GCNT2) 428479
MGP: 
100539032
ACS: 
100558219 100558415
XLA: 
432275(gcnt2)
XTR: 
100038221(gcnt2)
BFO: 
BRAFLDRAFT_138210
SPU: 
579029
NVE: 
NEMVE_v1g110143
 » show all
Taxonomy
Reference
1  [PMID:6219989]
  Authors
van den Eijnden DH, Winterwerp H, Smeeman P, Schiphorst WE.
  Title
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.
  Journal
J. Biol. Chem. 258 (1983) 3435-7.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85638-40-0
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