KEGG   ENZYME: 2.4.1.152Help
Entry
EC 2.4.1.152                Enzyme                                 
Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase;
Lewis-negative alpha-3-fucosyltransferase;
plasma alpha-3-fucosyltransferase;
guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase;
galactoside 3-fucosyltransferase;
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Reaction(IUBMB)
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R [RN:R03519]
Reaction(KEGG)
R03519 > R05904(G) R06025(G) R06038(G) R06039(G);
(other) R06075(G) R06076(G) R06095(G)
Show
Substrate
GDP-beta-L-fucose [CPD:C00325];
(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
Product
GDP [CPD:C00035];
(1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R
Comment
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
Pathway
Other types of O-glycan biosynthesis
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K03663  
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
Genes
HSA: 
10690(FUT9)
PTR: 
449500(FUT9)
PPS: 
GGO: 
PON: 
MCC: 
708361(FUT9)
MMU: 
14348(Fut9)
RNO: 
84597(Fut9)
CFA: 
449027(FUT9)
AML: 
BTA: 
282853(FUT9)
ECB: 
100071396
MDO: 
100020278(FUT9)
SHR: 
100925710
OAA: 
100075626
GGA: 
771133(FUT9)
MGP: 
100538515
ACS: 
100565195
XLA: 
100337597(fut9)
XTR: 
548391(fut9)
DRE: 
796410
TRU: 
446062(fut9a)
OLA: 
100302422(fut9a)
 » show all
Taxonomy
Reference
1  [PMID:7295318]
  Authors
Johnson PH, Yates AD, Watkins WM.
  Title
Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene.
  Journal
Biochem. Biophys. Res. Commun. 100 (1981) 1611-8.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Reference
3  [PMID:12676935]
  Authors
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE.
  Title
C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer.
  Journal
J. Biol. Chem. 278 (2003) 21893-900.
  Organism
Homo sapiens [GN:hsa], Helicobacter pylori
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39279-34-0
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