KEGG   ENZYME: 2.4.1.152Help
Entry
EC 2.4.1.152                Enzyme                                 

Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase;
Lewis-negative alpha-3-fucosyltransferase;
plasma alpha-3-fucosyltransferase;
guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase;
galactoside 3-fucosyltransferase;
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Reaction(IUBMB)
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R [RN:R03519]
Reaction(KEGG)
R03519 > R05904(G) R06025(G) R06038(G) R06039(G);
(other) R06075(G) R06076(G) R06095(G)
Show
Substrate
GDP-beta-L-fucose [CPD:C00325];
(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
Product
GDP [CPD:C00035];
(1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R
Comment
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
History
EC 2.4.1.152 created 1984, modified 2002
Pathway
Other types of O-glycan biosynthesis
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K03663  
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
Genes
HSA: 
10690(FUT9)
PTR: 
449500(FUT9)
PPS: 
GGO: 
PON: 
MCC: 
708361(FUT9)
MCF: 
MMU: 
14348(Fut9)
RNO: 
84597(Fut9)
CGE: 
100689036(Fut9)
HGL: 
TUP: 
102469465(FUT9)
CFA: 
449027(FUT9)
AML: 
FCA: 
101080384(FUT9)
PTG: 
102953801(FUT9)
BTA: 
282853(FUT9)
BOM: 
102265797(FUT9)
PHD: 
102325045(FUT9)
CHX: 
102190604(FUT9)
SSC: 
102160171(FUT9)
CFR: 
102504781(FUT9)
BACU: 
103013395(FUT9)
LVE: 
103076056(FUT9)
ECB: 
MYB: 
102244048(FUT9)
MYD: 
102761474(FUT9)
PALE: 
102880999(FUT9)
MDO: 
100020278(FUT9)
SHR: 
OAA: 
100075626(FUT9)
GGA: 
771133(FUT9)
MGP: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
102381575(FUT9)
AMJ: 
PSS: 
102445061(FUT9)
CMY: 
102943905(FUT9)
ACS: 
PBI: 
XLA: 
100337597(fut9)
XTR: 
548391(fut9)
DRE: 
796410(fut9a)
TRU: 
101073723 101074839 445968(fut9b) 445969(fut9c) 446062(fut9a)
MZE: 
OLA: 
100302422(fut9a) 100302423(fut9b) 100302424(fut9c)
XMA: 
LCM: 
102347013(FUT9)
CMK: 
CIN: 
 » show all
Taxonomy
Reference
1  [PMID:7295318]
  Authors
Johnson PH, Yates AD, Watkins WM.
  Title
Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene.
  Journal
Biochem. Biophys. Res. Commun. 100 (1981) 1611-8.
  Organism
Homo sapiens
Reference
2  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods. Enzymol. 98 (1983) 98-134.
Reference
3  [PMID:12676935]
  Authors
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE.
  Title
C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer.
  Journal
J. Biol. Chem. 278 (2003) 21893-900.
  Organism
Homo sapiens, Helicobacter pylori
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39279-34-0

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