KEGG   ENZYME: 2.4.1.155Help
Entry
EC 2.4.1.155                Enzyme                                 

Name
alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase V;
alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase;
UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase;
alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase;
GnTV
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [RN:R04665]
Reaction(KEGG)
R04665;
(other) R05991(G)
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C04944]
Product
UDP [CPD:C00015];
6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [CPD:C05159]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram).
History
EC 2.4.1.155 created 1986, modified 2001
Pathway
N-Glycan biosynthesis
Metabolic pathways
Orthology
K00744  
alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
Genes
HSA: 
4249(MGAT5)
PTR: 
459625(MGAT5)
PPS: 
100989629(MGAT5)
GGO: 
101129003(MGAT5)
PON: 
100445523(MGAT5)
NLE: 
100597446(MGAT5)
MCC: 
709108(MGAT5)
MCF: 
102123398(MGAT5)
CJC: 
100414526(MGAT5)
MMU: 
107895(Mgat5)
RNO: 
65271(Mgat5)
CGE: 
100760162(Mgat5)
NGI: 
103733594(Mgat5)
HGL: 
101721991(Mgat5)
OCU: 
100346879(MGAT5)
TUP: 
102497975(MGAT5)
CFA: 
483895(MGAT5)
AML: 
100483104(MGAT5)
UMR: 
103667662(MGAT5)
FCA: 
101088682(MGAT5)
PTG: 
102969054(MGAT5)
BTA: 
537595(MGAT5)
BOM: 
102275628(MGAT5)
PHD: 
102335781(MGAT5)
CHX: 
102174983(MGAT5)
OAS: 
101107672(MGAT5)
SSC: 
100512563(MGAT5)
CFR: 
102521418(MGAT5)
BACU: 
102997655(MGAT5)
LVE: 
103072240(MGAT5)
ECB: 
100050356(MGAT5)
MYB: 
102246850(MGAT5)
MYD: 
102761898(MGAT5)
PALE: 
102884190(MGAT5)
MDO: 
100011845(MGAT5)
SHR: 
100929992(MGAT5)
OAA: 
100091600(MGAT5)
GGA: 
424286(MGAT5)
MGP: 
APLA: 
101797784(MGAT5)
TGU: 
100228988(MGAT5)
FAB: 
101814359(MGAT5)
PHI: 
102101886(MGAT5)
FPG: 
101918414(MGAT5)
FCH: 
102055854(MGAT5)
CLV: 
102084918(MGAT5)
ASN: 
102386992(MGAT5)
AMJ: 
102563315(MGAT5)
PSS: 
102455461(MGAT5)
CMY: 
102946323(MGAT5)
ACS: 
100566008(mgat5)
PBI: 
XTR: 
100145551(mgat5)
DRE: 
724006(mgat5)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102363158(MGAT5)
CMK: 
103180379(mgat5) 103184928(ccdc126)
BFO: 
CIN: 
SPU: 
CEL: 
CBR: 
CBG12645(Cbr-gly-2)
BMY: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
MPP: 
MRR: 
 » show all
Taxonomy
Reference
1  [PMID:6216250]
  Authors
Cummings RD, Trowbridge IS, Kornfeld S.
  Title
A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase.
  Journal
J. Biol. Chem. 257 (1982) 13421-7.
Reference
2  [PMID:2834054]
  Authors
Hindsgaul O, Tahir SH, Srivastava OP, Pierce M.
  Title
The trisaccharide beta-D-GlcpNAc-(1----2)-alpha-D-Manp-(1----6)-beta-D-Manp, as its 8-methoxycarbonyloctyl glycoside, is an acceptor selective for N-acetylglucosaminyltransferase V.
  Journal
Carbohydr. Res. 173 (1988) 263-72.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83588-90-3

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