KEGG   ENZYME: 2.4.1.174Help
Entry
EC 2.4.1.174                Enzyme                                 

Name
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase;
N-acetylgalactosaminyltransferase I;
glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I;
UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan [RN:R05929]
Reaction(KEGG)
R05929(G)
Show
Substrate
UDP-N-acetyl-D-galactosamine [CPD:C00203];
beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
Product
UDP [CPD:C00015];
N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
Comment
Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
History
EC 2.4.1.174 created 1989, modified 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Metabolic pathways
Orthology
K00746  
chondroitin sulfate N-acetylgalactosaminyltransferase 1/2
Genes
HSA: 
55454(CSGALNACT2) 55790(CSGALNACT1)
PTR: 
450416(CSGALNACT2) 464030(CSGALNACT1)
PPS: 
100974901 100987599(CSGALNACT1) 100994377(CSGALNACT2)
GGO: 
101151962(CSGALNACT2) 101154228(CSGALNACT1)
PON: 
100172853(CSGALNACT2) 100442293(CSGALNACT1)
NLE: 
100583001(CSGALNACT1) 100602432(CSGALNACT2) 100605754
MCC: 
703703(CSGALNACT2) 704901(CSGALNACT1)
MCF: 
102125913(CSGALNACT1) 102136560(CSGALNACT2)
CJC: 
100399122(CSGALNACT2) 100407007(CSGALNACT1)
MMU: 
234356(Csgalnact1) 78752(Csgalnact2)
RNO: 
297554(Csgalnact2) 306375(Csgalnact1)
CGE: 
100754969(Csgalnact1) 100770830(Csgalnact2)
NGI: 
103733802(Csgalnact2) 103747604(Csgalnact1)
HGL: 
101700905(Csgalnact1) 101719048(Csgalnact2)
OCU: 
100339411(CSGALNACT1) 100339435(CSGALNACT2)
TUP: 
102468989(CSGALNACT2) 102490797(CSGALNACT1)
CFA: 
482831(CSGALNACT1) 486786(CSGALNACT2)
AML: 
100468746(CSGALNACT1) 100484755(CSGALNACT2)
UMR: 
103667936(CSGALNACT2) 103677036(CSGALNACT1)
FCA: 
101096311(CSGALNACT1) 101100841(CSGALNACT2)
PTG: 
102956824(CSGALNACT1) 102966347(CSGALNACT2)
BTA: 
509328(CSGALNACT2) 528057(CSGALNACT1)
BOM: 
102266543(CSGALNACT1) 102285203(CSGALNACT2)
PHD: 
102330279(CSGALNACT2) 102333649(CSGALNACT1)
CHX: 
102179349(CSGALNACT1) 102185714(CSGALNACT2)
OAS: 
101118243(CSGALNACT2) 101120469(CSGALNACT1)
SSC: 
100157878(CSGALNACT2) 100517735(CSGALNACT1)
CFR: 
102513810 102514190(CSGALNACT2) 102514921(CSGALNACT1)
BACU: 
103007226(CSGALNACT2) 103010484(CSGALNACT1)
LVE: 
103069443(CSGALNACT2) 103084873(CSGALNACT1)
ECB: 
100050200(CSGALNACT2) 100052192(CSGALNACT1)
MYB: 
102244364(CSGALNACT1) 102262652(CSGALNACT2)
MYD: 
102764495(CSGALNACT2) 102768920(CSGALNACT1)
PALE: 
102878385(CSGALNACT2) 102889741(CSGALNACT1)
MDO: 
100012272(CSGALNACT2) 100030310(CSGALNACT1)
SHR: 
100925396(CSGALNACT1) 100925905(CSGALNACT2)
OAA: 
100076249(CSGALNACT2) 100078026(CSGALNACT1)
GGA: 
422488(CSGALNACT1) 423632(CSGALNACT2)
MGP: 
100538576(CSGALNACT1) 100550089(CSGALNACT2)
APLA: 
101796158(CSGALNACT2) 101799131(CSGALNACT1)
TGU: 
100223510(CSGALNACT1) 100231851(CSGALNACT2)
FAB: 
101812240(CSGALNACT1) 101820745(CSGALNACT2)
PHI: 
102113363(CSGALNACT2) 102113419(CSGALNACT1)
FPG: 
101910473(CSGALNACT1) 101919107(CSGALNACT2)
FCH: 
102049509(CSGALNACT2) 102059429(CSGALNACT1)
CLV: 
102088612(CSGALNACT1) 102097544(CSGALNACT2)
ASN: 
102388579(CSGALNACT2) 102388616(CSGALNACT1)
AMJ: 
102562660(CSGALNACT1) 102567960(CSGALNACT2)
PSS: 
102447091(CSGALNACT1) 102458703(CSGALNACT2)
CMY: 
102940405(CSGALNACT2) 102945055(CSGALNACT1)
ACS: 
100558813(csgalnact2) 100560783(csgalnact1)
PBI: 
103048163(CSGALNACT1) 103058428(CSGALNACT2)
XTR: 
100124741(csgalnact2) 100497098(csgalnact1)
DRE: 
560826(csgalnact2) 793671(csgalnact1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102358556(CSGALNACT2) 102366614(CSGALNACT1)
CMK: 
103181211(csgalnact2) 103186731(csgalnact1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
PHU: 
LGI: 
NVE: 
HMG: 
CCP: 
 » show all
Taxonomy
Reference
1  [PMID:3922754]
  Authors
Rohrmann K, Niemann R, Buddecke E.
  Title
Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate.
  Journal
Eur. J. Biochem. 148 (1985) 463-9.
Reference
2  [PMID:11788602]
  Authors
Uyama T, Kitagawa H, Tamura Ji J, Sugahara K.
  Title
Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.
  Journal
J. Biol. Chem. 277 (2002) 8841-6.
  Sequence
[hsa:55790]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
96189-39-8

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