| Entry |
|
|---|
| Name |
glucuronylgalactosylproteoglycan
4-beta-N-acetylgalactosaminyltransferase;
N-acetylgalactosaminyltransferase I;
glucuronylgalactosylproteoglycan
beta-1,4-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-chondroitin
acetylgalactosaminyltransferase I;
UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-
proteoglycan beta-1,4-N-acetylgalactosaminyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1->3)-beta-D-galactosyl-p
roteoglycan 4-beta-N-acetylgalactosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-galactosamine +
beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP +
N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-
galactosylproteoglycan [RN:R05929] |
|---|
| Reaction(KEGG) |
R05929(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-galactosamine [CPD:C00203];
beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan |
|---|
| Product |
UDP [CPD:C00015];
N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-
galactosylproteoglycan |
|---|
| Cofactor |
Manganese [CPD:C00034] |
|---|
| Comment |
Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate.
Key enzyme activity for the initiation of chondroitin and dermatan
sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core. |
|---|
| Pathway |
PATH: ec00532 Chondroitin sulfate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00746 N-acetylgalactosaminyltransferase I |
|---|
| Genes |
HSA: 55454(CSGALNACT2) 55790(CSGALNACT1)
PTR: 450416(CSGALNACT2) 464030(CSGALNACT1)
MCC: 703703 704901
MMU: 234356(Csgalnact1) 78752(Csgalnact2)
RNO: 297554(Csgalnact2) 306375(Csgalnact1)
CFA: 482831(CSGALNACT1) 486786(CSGALNACT2)
BTA: 509328(CSGALNACT2) 528057(CSGALNACT1)
SSC: 100155287 100157878
ECB: 100050200(CSGALNACT2) 100052192
MDO: 100012272 100030310
OAA: 100076249 100078026
GGA: 422488(CSGALNACT1) 423632(CSGALNACT2)
TGU: 100223510 100231851
XTR: 100124741(csgalnact2)
DRE: 560826(DKEY-192P21.4) 793671
BFO: BRAFLDRAFT_123885
CIN: 100177589
SPU: 579124
DME: Dmel_CG12913
DPO: Dpse_GA11904
DAN: Dana_GF12786
DER: Dere_GG24153
DPE: Dper_GL11584
DSE: Dsec_GM21196
DSI: Dsim_GD10724
DYA: Dyak_GE19348
DGR: Dgri_GH21775
DMO: Dmoj_GI19322
AGA: AgaP_AGAP007720
AAG: AaeL_AAEL013572
CQU: CpipJ_CPIJ019283
NVE: NEMVE_v1g177601
HMG: 100201765
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3922754]
Rohrmann K, Niemann R, Buddecke E.
Two N-acetylgalactosaminyltransferase are involved in the
biosynthesis of chondroitin sulfate.
Eur. J. Biochem. 148 (1985) 463-9.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:11788602]
Uyama T, Kitagawa H, Tamura Ji J, Sugahara K.
Molecular cloning and expression of human chondroitin
N-acetylgalactosaminyltransferase: the key enzyme for chain
initiation and elongation of chondroitin/dermatan sulfate on the
protein linkage region tetrasaccharide shared by heparin/heparan
sulfate.
J. Biol. Chem. 277 (2002) 8841-6.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.174
IUBMB Enzyme Nomenclature: 2.4.1.174
ExPASy - ENZYME nomenclature database: 2.4.1.174
BRENDA, the Enzyme Database: 2.4.1.174
CAS: 96189-39-8 |
|---|
