KEGG   ENZYME: 2.4.1.175Help
Entry
EC 2.4.1.175                Enzyme                                 

Name
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase;
N-acetylgalactosaminyltransferase II;
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
chondroitin synthase;
glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II;
UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan [RN:R04603]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Comment
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.
History
EC 2.4.1.175 created 1989, modified 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Metabolic pathways
Orthology
K00746  
chondroitin sulfate N-acetylgalactosaminyltransferase 1/2
K00747  
chondroitin polymerizing factor
K13499  
chondroitin sulfate synthase
K13500  
chondroitin synthase
Genes
HSA: 
22856(CHSY1) 337876(CHSY3) 55454(CSGALNACT2) 55790(CSGALNACT1) 79586(CHPF)
PTR: 
450416(CSGALNACT2) 464030(CSGALNACT1) 467777(CHSY1) 471623(CHSY3) 743513(CHPF)
PPS: 
100968775(CHSY1) 100971582(CHPF) 100972801 100987599(CSGALNACT1) 100994377(CSGALNACT2)
GGO: 
101126045(CHSY3) 101136357(CHSY1) 101144411(CHPF) 101151962(CSGALNACT2) 101154228(CSGALNACT1)
PON: 
100172853(CSGALNACT2) 100442293(CSGALNACT1) 100449809(CHSY1) 100455730(CHPF)
MCC: 
100423555(CHSY3) 694481(CHSY1) 703703(CSGALNACT2) 703860(CHPF) 704901(CSGALNACT1) 705715
MCF: 
101866114 102125913(CSGALNACT1) 102136125(CHSY1) 102136240(CHSY3) 102136560(CSGALNACT2)
MMU: 
234356(Csgalnact1) 269941(Chsy1) 74241(Chpf) 78752(Csgalnact2) 78923(Chsy3)
RNO: 
100910780 291577(Chsy3) 292999(Chsy1) 297554(Csgalnact2) 306375(Csgalnact1) 316533(Chpf)
CGE: 
100754969(Csgalnact1) 100765856(Chpf) 100767985(Chsy3) 100770803(Chsy1) 100770830(Csgalnact2)
HGL: 
101700301(Chsy1) 101700905(Csgalnact1) 101701741(Chsy3) 101707555(Chpf) 101719048(Csgalnact2)
TUP: 
102468989(CSGALNACT2) 102488411(CHPF) 102490797(CSGALNACT1) 102491913(CHSY3) 102495682(CHSY1)
CFA: 
481492(CHSY3) 482831(CSGALNACT1) 486786(CSGALNACT2) 488539(CHPF) 488704(CHSY1)
AML: 
100466495(CHSY1) 100468746(CSGALNACT1) 100484507(CHSY3) 100484755(CSGALNACT2)
FCA: 
101083179(CHSY1) 101092580(CHSY3) 101096311(CSGALNACT1) 101097752(CHPF) 101100841(CSGALNACT2)
PTG: 
102952320(CHSY1) 102956824(CSGALNACT1) 102959394(CHPF) 102966347(CSGALNACT2) 102971026(CHSY3)
BTA: 
281690(CHSY1) 509328(CSGALNACT2) 528057(CSGALNACT1) 528149(CHSY3) 540002(CHPF)
BOM: 
102266543(CSGALNACT1) 102281638(CHSY1) 102281650(CHSY3) 102284379(CHPF) 102285203(CSGALNACT2)
PHD: 
102319423(CHPF) 102326020 102327197 102330279(CSGALNACT2) 102333649(CSGALNACT1) 102334956 102344003(CHSY1)
CHX: 
102170413(CHSY3) 102179324(CHSY1) 102179349(CSGALNACT1) 102181823(CHPF) 102185714(CSGALNACT2)
SSC: 
100157878(CSGALNACT2) 100517735(CSGALNACT1) 100518720(CHSY3) 100520288(CHSY1) 100623047(CHPF) 102163855
CFR: 
102504589(CHSY3) 102513810 102514190(CSGALNACT2) 102514921(CSGALNACT1) 102523829(CHSY1) 102524541(CHPF)
BACU: 
103007226(CSGALNACT2) 103010484(CSGALNACT1) 103011106(CHPF) 103012595(CHSY1) 103019431(CHSY3)
LVE: 
103069443(CSGALNACT2) 103069960(CHPF) 103072590(CHSY3) 103082442(CHSY1) 103083412 103084873(CSGALNACT1)
ECB: 
100050200(CSGALNACT2) 100052192(CSGALNACT1) 100057477(CHSY1) 100059511(CHPF) 100072984(CHSY3)
MYB: 
102240097(CHPF) 102240619(CHSY3) 102244364(CSGALNACT1) 102249440 102262652(CSGALNACT2)
MYD: 
102761493(CHPF) 102764495(CSGALNACT2) 102767110(CHSY3) 102768473(CHSY1) 102768920(CSGALNACT1)
PALE: 
102878385(CSGALNACT2) 102881434(CHPF) 102889741(CSGALNACT1) 102890373(CHSY1) 102895704 102897068(CHSY3)
MDO: 
100010621(CHPF) 100012272(CSGALNACT2) 100020781(CHSY1) 100030310(CSGALNACT1)
SHR: 
100913326(CHPF) 100923374(CHSY1) 100925396(CSGALNACT1) 100925905(CSGALNACT2)
OAA: 
100076249(CSGALNACT2) 100078026(CSGALNACT1) 100680815 103170669(CHSY1)
GGA: 
415521(CHSY1) 415598(CHSY3) 422488(CSGALNACT1) 423632(CSGALNACT2) 769112(CHPF)
MGP: 
100538576(CSGALNACT1) 100540185(CHSY1) 100550036 100550089(CSGALNACT2) 100550164(CHSY3)
TGU: 
100222602(CHSY1) 100223510(CSGALNACT1) 100223757(CHSY3) 100225582(CHPF) 100231851(CSGALNACT2)
FAB: 
101809918(CHPF) 101812240(CSGALNACT1) 101812932(CHSY3) 101818662(CHSY1) 101820745(CSGALNACT2)
PHI: 
102104336(CHSY1) 102105051(CHPF) 102107624(CHSY3) 102113363(CSGALNACT2) 102113419(CSGALNACT1)
APLA: 
101796158(CSGALNACT2) 101799131(CSGALNACT1) 101799372(CHSY3) 101800894(CHPF) 101801430(CHSY1)
FPG: 
101910473(CSGALNACT1) 101919107(CSGALNACT2) 101919161(CHSY1) 101919353(CHSY3) 101923812(CHPF)
FCH: 
102049509(CSGALNACT2) 102054731(CHSY1) 102054841(CHSY3) 102056391(CHPF) 102059429(CSGALNACT1)
CLV: 
102088360(CHPF) 102088612(CSGALNACT1) 102090190(CHSY1) 102091017(CHSY3) 102097544(CSGALNACT2)
ASN: 
102375772(CHSY1) 102384714(CHSY3) 102388579(CSGALNACT2) 102388616(CSGALNACT1) 102388640(CHPF)
AMJ: 
102562491(CHSY1) 102562660(CSGALNACT1) 102566190(CHSY3) 102567960(CSGALNACT2) 102572614 102572696(CHPF)
PSS: 
102444940(CHSY3) 102446783(CHPF) 102447091(CSGALNACT1) 102458703(CSGALNACT2) 102459255(CHSY1)
CMY: 
102932901(CHPF) 102938881(CHSY1) 102939048(CHSY3) 102940405(CSGALNACT2) 102945055(CSGALNACT1)
ACS: 
100554248(chsy1) 100556433(chsy3) 100558813(csgalnact2) 100560221 100560783(csgalnact1)
PBI: 
103048163(CSGALNACT1) 103049632(CHSY3) 103057166(CHSY1) 103058428(CSGALNACT2) 103068101(CHPF)
XTR: 
100036707(chsy1) 100124741(csgalnact2) 100379780(chpf) 100494038(chsy3) 100497098(csgalnact1)
DRE: 
100331155(chpfa) 324407(chsy1) 368477(chsy3) 560826 793671
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346351 102357727(CHSY3) 102358556(CSGALNACT2) 102363926(CHPF) 102366614(CSGALNACT1) 102366930(CHSY1)
CMK: 
103172383 103178043(chsy3) 103181211(csgalnact2) 103186731(csgalnact1) 103187742(chsy1)
BFO: 
CIN: 
SPU: 
579124 579341(CHSY1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413549(GB13893)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_PAR2.4(mig-22) CELE_T24D1.1(sqv-5)
CBR: 
CBG03828(Cbr-sqv-5) CBG06915(Cbr-mig-22)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
AQU: 
GSL: 
CCP: 
PMU: 
FBL: 
CPH: 
 » show all
Taxonomy
Reference
1  [PMID:3922754]
  Authors
Rohrmann K, Niemann R, Buddecke E.
  Title
Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate.
  Journal
Eur. J. Biochem. 148 (1985) 463-9.
  Organism
Bos taurus
Reference
2  [PMID:11514575]
  Authors
Kitagawa H, Uyama T, Sugahara K.
  Title
Molecular cloning and expression of a human chondroitin synthase.
  Journal
J. Biol. Chem. 276 (2001) 38721-6.
  Organism
Homo sapiens
  Sequence
[hsa:22856]
Reference
3  [PMID:10818104]
  Authors
DeAngelis PL, Padgett-McCue AJ.
  Title
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.
  Journal
J. Biol. Chem. 275 (2000) 24124-9.
  Organism
Pasteurella multocida
  Sequence
[pmu:PM0775]
Reference
4  [PMID:11943778]
  Authors
Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K.
  Title
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.
  Journal
J. Biol. Chem. 277 (2002) 21567-75.
  Organism
Escherichia coli
  Sequence
[up:Q8L0V4]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
96189-40-1

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