KEGG   ENZYME: 2.4.1.175Help
Entry
EC 2.4.1.175                Enzyme                                 

Name
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase;
N-acetylgalactosaminyltransferase II;
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
chondroitin synthase;
glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II;
UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan [RN:R04603]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Comment
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.
History
EC 2.4.1.175 created 1989, modified 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Metabolic pathways
Orthology
K00746  
chondroitin sulfate N-acetylgalactosaminyltransferase 1/2
K00747  
chondroitin polymerizing factor
K13499  
chondroitin sulfate synthase
K13500  
chondroitin synthase
Genes
HSA: 
22856(CHSY1) 337876(CHSY3) 55454(CSGALNACT2) 55790(CSGALNACT1) 79586(CHPF)
PTR: 
107972286(CHSY1) 450416(CSGALNACT2) 464030(CSGALNACT1) 467777(CHSY1) 471623(CHSY3) 743513(CHPF)
PPS: 
100968775(CHSY1) 100971582(CHPF) 100972801(CHSY3) 100974901 100987599(CSGALNACT1) 100994377(CSGALNACT2)
GGO: 
101126045(CHSY3) 101136357(CHSY1) 101144411(CHPF) 101151962(CSGALNACT2) 101154228(CSGALNACT1)
PON: 
100172853(CSGALNACT2) 100442293(CSGALNACT1) 100449809(CHSY1) 100455730(CHPF) 103888550
NLE: 
100583001(CSGALNACT1) 100588681(CHSY3) 100589763(CHPF) 100602432(CSGALNACT2) 100602507(CHSY1)
MCC: 
694481(CHSY1) 703703(CSGALNACT2) 703860(CHPF) 704901(CSGALNACT1) 705715(CHSY3)
MCF: 
101866114(CHPF) 102125913(CSGALNACT1) 102136125(CHSY1) 102136240(CHSY3) 102136560(CSGALNACT2)
CSAB: 
103215414(CSGALNACT1) 103215756(CSGALNACT2) 103217919(CHPF) 103231288(CHSY1) 103244479(CHSY3)
RRO: 
104653929(CSGALNACT2) 104660068(CHPF) 104662459(CSGALNACT1) 104676683(CHSY3) 104676811(CHSY1)
CJC: 
100392140(CHSY3) 100399122(CSGALNACT2) 100403329(CHPF) 100405485(CHSY1) 100407007(CSGALNACT1)
SBQ: 
101027448(CSGALNACT2) 101046087(CHPF) 101047506(CHSY3) 101048885(CSGALNACT1) 101054458(CHSY1)
MMU: 
234356(Csgalnact1) 269941(Chsy1) 74241(Chpf) 78752(Csgalnact2) 78923(Chsy3)
RNO: 
100910780(Chsy3l) 291577(Chsy3) 292999(Chsy1) 297554(Csgalnact2) 306375(Csgalnact1) 316533(Chpf)
CGE: 
100754969(Csgalnact1) 100765856(Chpf) 100767985(Chsy3) 100770803(Chsy1) 100770830(Csgalnact2)
NGI: 
103727760(Chpf) 103733802(Csgalnact2) 103747203(Chsy1) 103747604(Csgalnact1) 103751045(Chsy3)
HGL: 
101700301(Chsy1) 101700905(Csgalnact1) 101701741(Chsy3) 101707555(Chpf) 101719048(Csgalnact2)
OCU: 
100328892(CHPF) 100339411(CSGALNACT1) 100339435(CSGALNACT2) 100351896(CHSY3) 103351288(CHSY1)
TUP: 
102468989(CSGALNACT2) 102488411(CHPF) 102490797(CSGALNACT1) 102491913(CHSY3) 102495682(CHSY1)
CFA: 
481492(CHSY3) 482831(CSGALNACT1) 486786(CSGALNACT2) 488539(CHPF) 488704(CHSY1)
AML: 
100466495(CHSY1) 100468746(CSGALNACT1) 100484507(CHSY3) 100484755(CSGALNACT2) 105240013(CHPF)
UMR: 
103660037(CHSY1) 103662872(CHPF) 103667936(CSGALNACT2) 103670570(CHSY3) 103677036(CSGALNACT1)
FCA: 
101083179(CHSY1) 101096311(CSGALNACT1) 101097752(CHPF) 101100841(CSGALNACT2) 105260677(CHSY3)
PTG: 
102952320(CHSY1) 102956824(CSGALNACT1) 102959394(CHPF) 102966347(CSGALNACT2) 102971026(CHSY3)
AJU: 
106970041(CHPF) 106970692(CHSY3) 106972094(CHSY1) 106972130(CSGALNACT2) 106978257(CSGALNACT1)
BTA: 
281690(CHSY1) 509328(CSGALNACT2) 528057(CSGALNACT1) 528149(CHSY3) 540002(CHPF)
BOM: 
102266543(CSGALNACT1) 102281638(CHSY1) 102281650(CHSY3) 102284379(CHPF) 102285203(CSGALNACT2)
PHD: 
102319423(CHPF) 102326020 102327197 102330279(CSGALNACT2) 102333649(CSGALNACT1) 102334956 102344003(CHSY1)
CHX: 
102170413(CHSY3) 102179324(CHSY1) 102179349(CSGALNACT1) 102181823(CHPF) 102185714(CSGALNACT2)
OAS: 
101104485(CHSY3) 101109305(CHSY1) 101114088(CHPF) 101118243(CSGALNACT2) 101120469(CSGALNACT1) 105605252
SSC: 
100157878(CSGALNACT2) 100517735(CSGALNACT1) 100518720 100520288(CHSY1) 100623047(CHPF) 102163855(CHSY3)
CFR: 
102504589(CHSY3) 102513810 102514190(CSGALNACT2) 102514921(CSGALNACT1) 102523829(CHSY1) 102524541(CHPF)
BACU: 
103007226(CSGALNACT2) 103010484(CSGALNACT1) 103011106(CHPF) 103012595(CHSY1) 103019431(CHSY3)
LVE: 
103069443(CSGALNACT2) 103069960(CHPF) 103072590(CHSY3) 103082442(CHSY1) 103083412 103084873(CSGALNACT1)
ECB: 
100050200(CSGALNACT2) 100052192(CSGALNACT1) 100057477(CHSY1) 100059511(CHPF) 100072984(CHSY3)
MYB: 
102240097(CHPF) 102240619(CHSY3) 102244364(CSGALNACT1) 102249440(CHSY1) 102262652(CSGALNACT2)
MYD: 
102761493(CHPF) 102764495(CSGALNACT2) 102767110(CHSY3) 102768473(CHSY1) 102768920(CSGALNACT1)
HAI: 
109375394(CHSY3) 109380347(CHSY1) 109380579(CHPF) 109386291(CSGALNACT1) 109395550(CSGALNACT2)
PALE: 
102878385(CSGALNACT2) 102881434(CHPF) 102889741(CSGALNACT1) 102890373(CHSY1) 102897068(CHSY3)
LAV: 
100654033(CSGALNACT1) 100657082(CHSY1) 100661660(CSGALNACT2) 100671059(CHPF) 100677323(CHSY3)
MDO: 
100010621(CHPF) 100012272(CSGALNACT2) 100020781(CHSY1) 100030310(CSGALNACT1)
SHR: 
100913326(CHPF) 100923374(CHSY1) 100925396(CSGALNACT1) 100925905(CSGALNACT2)
OAA: 
100076249(CSGALNACT2) 100078026(CSGALNACT1) 100680815 103170669(CHSY1)
GGA: 
415521(CHSY1) 415598(CHSY3) 422488(CSGALNACT1) 423632(CSGALNACT2) 769112(CHPF)
MGP: 
100538576(CSGALNACT1) 100540185(CHSY1) 100550036(CHPF) 100550089(CSGALNACT2)
CJO: 
107306320(CHSY3) 107313214(CSGALNACT1) 107315593(CSGALNACT2) 107316900(CHPF) 107318958(CHSY1)
APLA: 
101796158(CSGALNACT2) 101799131(CSGALNACT1) 101799372(CHSY3) 101800894(CHPF) 101801430(CHSY1)
TGU: 
100222602(CHSY1) 100223510(CSGALNACT1) 100223757(CHSY3) 100225582(CHPF) 100231851(CSGALNACT2)
GFR: 
102033481(CSGALNACT1) 102038477(CHPF) 102041114(CHSY3) 102043050(CSGALNACT2) 102043414(CHSY1)
FAB: 
101809918(CHPF) 101812240(CSGALNACT1) 101812932(CHSY3) 101818662(CHSY1) 101820745(CSGALNACT2)
PHI: 
102104336(CHSY1) 102105051(CHPF) 102107624(CHSY3) 102113363(CSGALNACT2) 102113419(CSGALNACT1)
CCW: 
104684076(CHSY1) 104689810(CHSY3) 104690220(CSGALNACT2) 104693941(CHPF) 104697139(CSGALNACT1)
FPG: 
101910473(CSGALNACT1) 101919107(CSGALNACT2) 101919161(CHSY1) 101919353(CHSY3) 101923812(CHPF)
FCH: 
102049509(CSGALNACT2) 102054731(CHSY1) 102054841(CHSY3) 102056391(CHPF) 102059429(CSGALNACT1)
CLV: 
102088360(CHPF) 102088612(CSGALNACT1) 102090190(CHSY1) 102091017(CHSY3) 102097544(CSGALNACT2)
AAM: 
106484360(CSGALNACT1) 106495060(CHSY3) 106495829(CHSY1) 106498950(CSGALNACT2) 106499326(CHPF)
ASN: 
102375772(CHSY1) 102384714(CHSY3) 102388579(CSGALNACT2) 102388616(CSGALNACT1) 102388640(CHPF)
AMJ: 
102562491(CHSY1) 102562660(CSGALNACT2) 102566190(CHSY3) 102572696(CHPF) 106736723(CSGALNACT1)
PSS: 
102444940(CHSY3) 102446783(CHPF) 102447091(CSGALNACT1) 102458703(CSGALNACT2) 102459255(CHSY1)
CMY: 
102932901(CHPF) 102938881(CHSY1) 102939048(CHSY3) 102940405(CSGALNACT2) 102945055(CSGALNACT1)
CPIC: 
101937753(CSGALNACT2) 101942137(CHSY3) 101945190(CHSY1) 101949751(CHPF) 101950451(CSGALNACT1)
ACS: 
100554248(chsy1) 100556433(chsy3) 100558813(csgalnact2) 100560221(chpf) 100560783(csgalnact1)
PBI: 
103048163(CSGALNACT1) 103049632(CHSY3) 103057166(CHSY1) 103058428(CSGALNACT2) 103068101(CHPF)
GJA: 
107107034(CSGALNACT1) 107115005(CSGALNACT2) 107116102(CHSY1) 107119174 107123338(CHSY3) 107123996(CHPF)
XLA: 
100158319(chpf.L) 108696289(csgalnact2.L) 108702913(chpf.S) 108706822(csgalnact1.S) 108707191 108711484(chsy1.L) 108712229(csgalnact1.L) 108712816(chsy1.S) 108717241
XTR: 
100036707(chsy1) 100124741(csgalnact2) 100379780(chpf) 100494038(chsy3) 100497098(csgalnact1) 108645693
DRE: 
100331155(chpfa) 324407(chsy1) 368477(chsy3) 560826(csgalnact2) 793671(csgalnact1a)
IPU: 
108263569(csgalnact2) 108265223 108271046(chsy1) 108273176(chpf) 108277248(csgalnact1) 108277355(chsy3)
TRU: 
101061544(chpf) 101067591 101071007 101079035(chsy1) 101079052(csgalnact2) 101079135(csgalnact1)
TNG: 
LCO: 
104920113(csgalnact1) 104920841 104921883(csgalnact2) 104927007(chpf) 104929727(chsy1) 104937434(chsy3) 104939177
MZE: 
101469087 101469922(csgalnact1) 101473522(chsy3) 101474654 101476345(csgalnact2) 101478644(chsy1)
OLA: 
101155099(chpf) 101155793(csgalnact2) 101157180(chsy1) 101159591 101162617(csgalnact1) 105355887
XMA: 
SASA: 
LCM: 
102346351 102357727(CHSY3) 102358556(CSGALNACT2) 102363926(CHPF) 102366614(CSGALNACT1) 102366930(CHSY1)
CMK: 
103172383 103178043(chsy3) 103181211(csgalnact2) 103186731(csgalnact1) 103187742(chsy1)
BFO: 
CIN: 
SPU: 
579124 579341(CHSY1)
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD10724(Dsim_GD10724) Dsimw501_GD15794(Dsim_GD15794) Dsimw501_GD24523(Dsim_GD24523)
DWI: 
DYA: 
Dyak_GE16036(dyak_GLEANR_17496) Dyak_GE16179(dyak_GLEANR_17625) Dyak_GE19348(dyak_GLEANR_3121)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_PAR2.4(mig-22) CELE_T24D1.1(sqv-5)
CBR: 
CBG03828(Cbr-sqv-5) CBG06915(Cbr-mig-22)
BMY: 
LOA: 
TSP: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
AQU: 
GSL: 
CCP: 
PMU: 
PUL: 
PMP: 
Pmu_08530(hyaD)
PMUL: 
DR93_1611(hyaD)
FBL: 
AYM: 
CPH: 
 » show all
Taxonomy
Reference
1  [PMID:3922754]
  Authors
Rohrmann K, Niemann R, Buddecke E.
  Title
Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate.
  Journal
Eur. J. Biochem. 148 (1985) 463-9.
Reference
2  [PMID:11514575]
  Authors
Kitagawa H, Uyama T, Sugahara K.
  Title
Molecular cloning and expression of a human chondroitin synthase.
  Journal
J. Biol. Chem. 276 (2001) 38721-6.
  Sequence
[hsa:22856]
Reference
3  [PMID:10818104]
  Authors
DeAngelis PL, Padgett-McCue AJ.
  Title
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.
  Journal
J. Biol. Chem. 275 (2000) 24124-9.
  Sequence
[pmu:PM0775]
Reference
4  [PMID:11943778]
  Authors
Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K.
  Title
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.
  Journal
J. Biol. Chem. 277 (2002) 21567-75.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
96189-40-1

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