| Entry |
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| Name |
phosphatidylinositol N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase;
uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase
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| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN: R02654 R05916]
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| Reaction(KEGG) |
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| Substrate |
UDP-N-acetyl-D-glucosamine [CPD: C00043];
1-phosphatidyl-1D-myo-inositol [CPD: C01194]
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| Product |
UDP [CPD: C00015];
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD: C01288]
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| Comment |
Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
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| Pathway |
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | | Metabolic pathways |
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| Orthology |
| phosphatidylinositol glycan, class A |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | MTR: | | CSV: | | RCU: | | POP: | | VVI: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | OLU: | | OTA: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | MGL: | | PGR: | | ECU: | | EIN: | | EHE: | | NCE: | | MBR: | | NGR: | | DDI: | | DPP: | | EHI: | | EDI: | | PFA: | | PFD: | | PFH: | | PYO: | | PCB: | | PBE: | | PKN: | | PVX: | | PCY: | | TAN: | | TPV: | | BBO: | | CPV: | | CHO: | | TGO: | | TET: | | PTM: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | GLA: | | PTI: | | TPS: | |
» show all
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| Reference |
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| Authors |
Doering TL, Masterson WJ, Englund PT, Hart GW. |
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| Title |
Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine. |
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| Journal |
J. Biol. Chem. 264 (1989) 11168-73. |
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| Organism |
Trypanosoma brucei [GN: tbr] |
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| Reference |
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| Authors |
Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T. |
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| Title |
The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. |
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| Journal |
EMBO. J. 17 (1998) 877-85. |
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| Organism |
Homo sapiens [GN: hsa], Saccharomyces cerevisiae [GN: sce], Plasmodium falciparum [GN: pfa], Trypanosoma brucei [GN: tbr] |
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| Reference |
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| Authors |
Watanabe R, Murakami Y, Marmor MD, Inoue N, Maeda Y, Hino J, Kangawa K, Julius M, Kinoshita T. |
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| Title |
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. |
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| Journal |
EMBO. J. 19 (2000) 4402-11. |
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| Organism |
Plasmodium falciparum [GN: pfa], Trypanosoma brucei [GN: tbr] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 144388-35-2 |
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