KEGG   ENZYME: 2.4.1.201Help
Entry
EC 2.4.1.201                Enzyme                                 

Name
alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase VI;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI;
uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI;
mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTVI
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R = UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R [RN:R04642]
Reaction(KEGG)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R [CPD:C04906]
Product
UDP [CPD:C00015];
2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R [CPD:C04934]
Comment
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor (click here for diagram).
History
EC 2.4.1.201 created 1992, modified 2001
Pathway
N-Glycan biosynthesis
Metabolic pathways
Orthology
K13748  
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C
Genes
HSA: 
25834(MGAT4C)
PTR: 
467085(MGAT4C)
PPS: 
100992134(MGAT4C)
GGO: 
101151757(MGAT4C)
PON: 
100455323(MGAT4C)
MCC: 
MCF: 
101866242(MGAT4C)
MMU: 
67569(Mgat4c)
RNO: 
299756(Mgat4c)
CGE: 
100760589(Mgat4c)
HGL: 
101725010(Mgat4c)
TUP: 
102467784(MGAT4C)
CFA: 
475418(MGAT4C)
AML: 
100465193(MGAT4C)
FCA: 
101096077(MGAT4C)
PTG: 
102971513(MGAT4C)
BTA: 
539661(MGAT4C)
BOM: 
PHD: 
102325642(MGAT4C)
CHX: 
102169257(MGAT4C)
SSC: 
414851(MGAT4C)
CFR: 
102503714(MGAT4C)
ECB: 
100051064(MGAT4C)
MYB: 
MYD: 
102769462(MGAT4C)
PALE: 
102882602(MGAT4C)
MDO: 
100020942(MGAT4C)
SHR: 
100932381(MGAT4C)
OAA: 
100081053(MGAT4C)
GGA: 
395415(MGAT4C) 427873(MGAT4C)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XTR: 
100486336(mgat4c)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
SPU: 
TAD: 
MBR: 
 » show all
Taxonomy
Reference
1  [PMID:2525556]
  Authors
Brockhausen I, Hull E, Hindsgaul O, Schachter H, Shah RN, Michnick SW, Carver JP.
  Title
Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc beta 1-6 (GlcNAc beta 1-2)Man alpha-R (GlcNAc to Man) beta-4-N-acetylglucosaminyltransferase VI.
  Journal
J. Biol. Chem. 264 (1989) 11211-21.
  Organism
Gallus gallus
Reference
2  [PMID:10903319]
  Authors
Taguchi T, Ogawa T, Inoue S, Inoue Y, Sakamoto Y, Korekane H, Taniguchi N.
  Title
Purification and characterization of UDP-GlcNAc: GlcNAcbeta 1-6(GlcNAcbeta 1-2)Manalpha 1-R [GlcNAc to Man]-beta 1, 4-N-acetylglucosaminyltransferase VI from hen oviduct.
  Journal
J. Biol. Chem. 275 (2000) 32598-602.
  Organism
Gallus gallus
  Sequence
[gga:395415]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
119699-68-2

DBGET integrated database retrieval system