KEGG   ENZYME: 2.4.1.206Help
Entry
EC 2.4.1.206                Enzyme                                 

Name
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04493 R05971]
Reaction(KEGG)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
History
EC 2.4.1.206 created 1992
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K03766  
beta-1,3-N-acetylglucosaminyltransferase 5
Genes
HSA: 
84002(B3GNT5)
PTR: 
735383(B3GNT5)
PPS: 
100978128(B3GNT5)
GGO: 
101133247(B3GNT5)
PON: 
100438226(B3GNT5)
MCC: 
701071 705694(B3GNT5)
MCF: 
MMU: 
RNO: 
116740(B3gnt5)
CGE: 
100757919(B3gnt5)
HGL: 
TUP: 
CFA: 
102154559(B3GNT5)
AML: 
FCA: 
PTG: 
BTA: 
BOM: 
PHD: 
102327597(B3GNT5)
CHX: 
SSC: 
397599(B3GNT5)
CFR: 
102514403(B3GNT5)
BACU: 
103015740(B3GNT5)
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
100092498(B3GNT5) 100681736(B3GALT4)
GGA: 
417126(B3GNTL2) 424960(B3GNT5)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
PBI: 
XLA: 
446540(b3gnt5-b) 496364(b3gnt5-a)
XTR: 
DRE: 
101883349 336526(b3gnt5a) 791470(b3gnt5b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103184652 103190749(b3galt4) 103190900(b3gnt5)
BFO: 
TAD: 
GSL: 
 » show all
Taxonomy
Reference
1  [PMID:1825612]
  Authors
Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman HS, Bigner DD, Svennerholm L.
  Title
Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.
  Journal
Biochim. Biophys. Acta. 1081 (1991) 253-61.
  Organism
Homo sapiens
Reference
2  [PMID:2960671]
  Authors
Holmes EH, Hakomori S, Ostrander GK.
  Title
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
  Journal
J. Biol. Chem. 262 (1987) 15649-58.
  Organism
Homo sapiens
Reference
3  [PMID:1901591]
  Authors
Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.
  Title
Glycosphingolipid glycosyltransferases in human fetal brain.
  Journal
J. Neurochem. 56 (1991) 1461-5.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83682-80-8

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