| Entry |
|
|---|
| Name |
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide
beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide
beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-
glucosyl(11)ceramide 3-beta-N-acetylglucosaminyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-
(11)-ceramide 3-beta-N-acetylglucosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-glucosamine +
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide = UDP +
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-
glucosyl-(11)-ceramide [RN:R04493 R05971] |
|---|
| Reaction(KEGG) |
R04493 R05971(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide |
|---|
| Product |
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-
glucosyl-(11)-ceramide |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03766 beta-1,3-N-acetylglucosaminyltransferase 5 |
|---|
| Genes |
HSA: 84002(B3GNT5)
PTR: 735383(B3GNT5)
MCC: 705694(B3GNT5)
MMU: 108105(B3gnt5)
RNO: 116740(B3gnt5)
BTA: 767899(B3GNT5)
SSC: 397599(B3GNT5)
ECB: 100058694
MDO: 100015321
OAA: 100092498
GGA: 424960(B3GNT5)
TGU: 100224977
XLA: 446540(b3gnt5a) 496364(b3gnt5b)
XTR: 394849(b3gnt5)
DRE: 336526(b3gnt5)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:1825612]
Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman
HS, Bigner DD, Svennerholm L.
Glycolipids and glycosyltransferases in permanent cell lines
established from human medulloblastomas.
Biochim. Biophys. Acta. 1081 (1991) 253-61.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2960671]
Holmes EH, Hakomori S, Ostrander GK.
Synthesis of type 1 and 2 lacto series glycolipid antigens in human
colonic adenocarcinoma and derived cell lines is due to activation
of a normally unexpressed beta
1----3N-acetylglucosaminyltransferase.
J. Biol. Chem. 262 (1987) 15649-58.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:1901591]
Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.
Glycosphingolipid glycosyltransferases in human fetal brain.
J. Neurochem. 56 (1991) 1461-5.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.206
IUBMB Enzyme Nomenclature: 2.4.1.206
ExPASy - ENZYME nomenclature database: 2.4.1.206
BRENDA, the Enzyme Database: 2.4.1.206
CAS: 83682-80-8 |
|---|
