KEGG   ENZYME: 2.4.1.221Help
Entry
EC 2.4.1.221                Enzyme                                 

Name
peptide-O-fucosyltransferase;
GDP-L-fucose:polypeptide fucosyltransferase;
GDP-fucose protein O-fucosyltransferase;
GDP-fucose:polypeptide fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase
Reaction(IUBMB)
transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor [RN:R09295]
Reaction(KEGG)
R09295(G)
Show
Comment
Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
History
EC 2.4.1.221 created 2002
Pathway
Other types of O-glycan biosynthesis
Orthology
K03691  
peptide-O-fucosyltransferase
Genes
HSA: 
23275(POFUT2) 23509(POFUT1)
PTR: 
449504(POFUT1) 449505(POFUT2)
PPS: 
100974304(POFUT1) 100982903(POFUT2)
GGO: 
101147854(POFUT2) 101150837(POFUT1)
PON: 
100294553(POFUT1) 100454664(POFUT2)
MCC: 
711966(POFUT1) 721991
MCF: 
MMU: 
140484(Pofut1) 80294(Pofut2)
RNO: 
309686(Pofut2) 311551(Pofut1)
CGE: 
100753417(Pofut1) 100765129(Pofut2)
HGL: 
101705482(Pofut2) 101707778(Pofut1)
TUP: 
102494095(POFUT1) 102497145(POFUT2)
CFA: 
100855959(POFUT2) 609881(POFUT1)
AML: 
FCA: 
101086742(POFUT2) 101094335(POFUT1)
PTG: 
BTA: 
360194(POFUT1) 404083(POFUT2)
BOM: 
102273757(POFUT1) 102284798(POFUT2)
PHD: 
102334960(POFUT1) 102336641(POFUT2)
CHX: 
102174438(POFUT2) 102185013(POFUT1)
SSC: 
100153934 100738385(POFUT2) 397627(POFUT1)
CFR: 
BACU: 
103011309(POFUT2) 103014718(POFUT1)
LVE: 
103076939(POFUT1) 103085778(POFUT2)
ECB: 
100055890(POFUT2) 100068638(POFUT1)
MYB: 
102246188(POFUT1) 102252154(POFUT2)
MYD: 
102763905(POFUT1) 102766539(POFUT2)
PALE: 
102880623(POFUT2) 102890765(POFUT1)
MDO: 
SHR: 
100913462(POFUT1) 100928136(POFUT2)
OAA: 
100076963(POFUT2) 100088179(POFUT1)
GGA: 
395070(POFUT1) 395112(POFUT2)
MGP: 
TGU: 
FAB: 
PHI: 
102101164(POFUT1) 102106960(POFUT2)
APLA: 
FPG: 
101911006(POFUT2) 101923244(POFUT1)
FCH: 
102049839(POFUT1) 102058325(POFUT2)
CLV: 
102089223(POFUT2) 102092521(POFUT1)
ASN: 
102373385(POFUT2) 102378150(POFUT1)
AMJ: 
PSS: 
102443515(POFUT1) 102455022(POFUT2)
CMY: 
102940672(POFUT1) 102946661(POFUT2)
ACS: 
PBI: 
103049826(POFUT2) 103056988(POFUT1)
XLA: 
398423(pofut1)
XTR: 
496411(pofut1) 779585(pofut2)
DRE: 
403029(pofut1) 777668(pofut2)
TRU: 
445894(fut13) 445971(fut12)
MZE: 
OLA: 
100125467(pofut1) 100125468(pofut2)
XMA: 
LCM: 
102348539(POFUT2) 102355355(POFUT1)
CMK: 
103176848(pofut2)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG12366(O-fut1) Dmel_CG14789(O-fut2)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE13556(Dyak_O-fut1) Dyak_GE16526(Dyak_O-fut2)
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551457(O-fut1) 724730(O-fut2)
NVI: 
TCA: 
BMOR: 
692614(pofut1) 692681(pofut2)
API: 
PHU: 
ISC: 
CEL: 
CELE_C15C7.7(C15C7.7) CELE_K10G9.3(pad-2)
CBR: 
CBG14147 CBG24618(Cbr-pad-2)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0003s07110g(POPTRDRAFT_817154)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os07t0572600-01(Os07g0572600)
OBR: 
BDI: 
SBI: 
SORBI_02g037060(SORBIDRAFT_02g037060)
SITA: 
ATR: 
s00147p00102480(AMTR_s00147p00102480)
SMO: 
PPP: 
MBR: 
PFA: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
CPV: 
CHO: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:9525914]
  Authors
Wang Y, Spellman MW.
  Title
Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells.
  Journal
J. Biol. Chem. 273 (1998) 8112-8.
  Organism
Cricetulus griseus
  Sequence
[cge:100753417]
Reference
2  [PMID:11524432]
  Authors
Wang Y, Shao L, Shi S, Harris RJ, Spellman MW, Stanley P, Haltiwanger RS.
  Title
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
  Journal
J. Biol. Chem. 276 (2001) 40338-45.
  Organism
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus
  Sequence
[cel:CELE_C15C7.7] [dme:Dmel_CG12366] [hsa:23509] [mmu:140484]
Reference
3  [PMID:9023546]
  Authors
Wang Y, Lee GF, Kelley RF, Spellman MW.
  Title
Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains.
  Journal
Glycobiology. 6 (1996) 837-42.
  Organism
Rattus norvegicus, Cricetulus griseus
  Sequence
[rno:311551] [cge:100753417]
Reference
4  [PMID:11067851]
  Authors
Hofsteenge J, Huwiler KG, Macek B, Hess D, Lawler J, Mosher DF, Peter-Katalinic J.
  Title
C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
  Journal
J. Biol. Chem. 276 (2001) 6485-98.
  Organism
Homo sapiens
  Sequence
[hsa:23275]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-08-3

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