KEGG   ENZYME: 2.4.1.221Help
Entry
EC 2.4.1.221                Enzyme                                 
Name
peptide-O-fucosyltransferase;
GDP-L-fucose:polypeptide fucosyltransferase;
GDP-fucose protein O-fucosyltransferase;
GDP-fucose:polypeptide fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase
Reaction(IUBMB)
transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor [RN:R09295]
Reaction(KEGG)
R09295(G)
Show
Comment
Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
Pathway
Other types of O-glycan biosynthesis
Orthology
K03691  
peptide-O-fucosyltransferase
Genes
HSA: 
23275(POFUT2) 23509(POFUT1)
PTR: 
449504(POFUT1) 449505(POFUT2)
PPS: 
100974304(POFUT1) 100982903(POFUT2)
GGO: 
101147854(POFUT2) 101150837(POFUT1)
PON: 
100294553(POFUT1) 100454664(POFUT2)
MCC: 
711966(POFUT1) 721991
MMU: 
140484(Pofut1) 80294(Pofut2)
RNO: 
309686(Pofut2) 311551(Pofut1)
CFA: 
AML: 
FCA: 
101086742(POFUT2) 101094335(POFUT1)
BTA: 
360194(POFUT1) 404083(POFUT2)
SSC: 
100153934 100738385 397627(POFUT1)
ECB: 
100055890 100068638
MDO: 
100010283 100017276
SHR: 
100913462(POFUT1) 100928136(POFUT2)
OAA: 
100076963 100088179
GGA: 
395070(POFUT1) 395112(POFUT2)
MGP: 
100544049 100547768(POFUT2)
TGU: 
100219075(POFUT1) 100228829
ACS: 
100557912 100562354
XLA: 
398423(pofut1)
XTR: 
496411(pofut1) 779585(pofut2)
DRE: 
403029(pofut1) 777668(pofut2)
TRU: 
445894(fut13) 445971(fut12)
OLA: 
100125467(pofut1) 100125468(pofut2)
BFO: 
BRAFLDRAFT_129871 BRAFLDRAFT_78575 BRAFLDRAFT_87806
CIN: 
100181584 445727(fut13)
SPU: 
578163 585387
DME: 
Dmel_CG12366(O-fut1) Dmel_CG14789(O-fut2)
DPO: 
Dpse_GA11584(Dpse_O-fut1) Dpse_GA13247
DAN: 
Dana_GF12028 Dana_GF21276
DER: 
Dere_GG12697 Dere_GG20425
DPE: 
Dper_GL11249 Dper_GL14377
DSE: 
Dsec_GM18972 Dsec_GM21511
DSI: 
Dsim_GD11022 Dsim_GD24636
DWI: 
Dwil_GK22169 Dwil_GK25021
DYA: 
Dyak_GE13556(Dyak_O-fut1) Dyak_GE16526(Dyak_O-fut2)
DGR: 
Dgri_GH11874 Dgri_GH22788
DMO: 
Dmoj_GI15662 Dmoj_GI20583
DVI: 
Dvir_GJ19195 Dvir_GJ20763
AGA: 
AgaP_AGAP000757 AgaP_AGAP011338
AAG: 
AaeL_AAEL000839 AaeL_AAEL004163
CQU: 
CpipJ_CPIJ010627 CpipJ_CPIJ013732
AME: 
551457(O-fut1) 724730(O-fut2)
NVI: 
100118147(NV15910)
TCA: 
662820 663255
API: 
100163639 100169478
PHU: 
Phum_PHUM091880 Phum_PHUM129460
ISC: 
IscW_ISCW001300 IscW_ISCW015119 IscW_ISCW022327
CEL: 
CELE_C15C7.7(C15C7.7)
CBR: 
CBG14147 CBG24618(Cbr-pad-2)
BMY: 
Bm1_16120 Bm1_39355
TSP: 
Tsp_00008 Tsp_05840
SMM: 
Smp_065240 Smp_131810
NVE: 
NEMVE_v1g124761 NEMVE_v1g187029 NEMVE_v1g99372
HMG: 
100197986 100204988
TAD: 
TRIADDRAFT_14457 TRIADDRAFT_21697 TRIADDRAFT_50901
AQU: 
100634689
ATH: 
AT1G17270 AT1G53770 AT5G50420
ALY: 
ARALYDRAFT_474511 ARALYDRAFT_889130 ARALYDRAFT_918074
GMX: 
100776069
MTR: 
MTR_8g023490
CSV: 
101208722 101230373
RCU: 
RCOM_0995430
POP: 
POPTR_817154
VVI: 
100254979
OSA: 
4343677
DOSA: 
Os07t0572600-01(Os07g0572600)
BDI: 
100825796
SBI: 
SORBI_02g037060(SORBIDRAFT_02g037060)
SMO: 
SELMODRAFT_94197(GT68A1)
PPP: 
PHYPADRAFT_232070
MBR: 
MONBRDRAFT_12575 MONBRDRAFT_25935
PFA: 
PFI0445c
PFH: 
PFHG_00144
PYO: 
PY03133
PCB: 
PC000119.05.0
PBE: 
PB000761.02.0
PKN: 
PKH_070660
PVX: 
PVX_098900
PCY: 
PCYB_071700
CPV: 
cgd1_2440
CHO: 
Chro.10274
 » show all
Taxonomy
Reference
1  [PMID:9525914]
  Authors
Wang Y, Spellman MW.
  Title
Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells.
  Journal
J. Biol. Chem. 273 (1998) 8112-8.
  Organism
Cricetulus griseus
Reference
2  [PMID:11524432]
  Authors
Wang Y, Shao L, Shi S, Harris RJ, Spellman MW, Stanley P, Haltiwanger RS.
  Title
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
  Journal
J. Biol. Chem. 276 (2001) 40338-45.
  Organism
Cricetulus griseus
Reference
3  [PMID:9023546]
  Authors
Wang Y, Lee GF, Kelley RF, Spellman MW.
  Title
Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains.
  Journal
Glycobiology. 6 (1996) 837-42.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:11067851]
  Authors
Hofsteenge J, Huwiler KG, Macek B, Hess D, Lawler J, Mosher DF, Peter-Katalinic J.
  Title
C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
  Journal
J. Biol. Chem. 276 (2001) 6485-98.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-08-3
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