| Entry |
|
|---|
| Name |
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase;
chondroitin glucuronyltransferase II;
alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-
glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D
-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-alpha-D-glucuronate +
N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-
proteoglycan = UDP +
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-
beta-D-glucuronosyl-proteoglycan [RN:R07336] |
|---|
| Reaction(KEGG) |
R07336 > R05931(G) R05933(G)
 |
|---|
| Substrate |
UDP-alpha-D-glucuronate [CPD:C00167];
N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-
proteoglycan |
|---|
| Product |
UDP [CPD:C00015];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-
beta-D-glucuronosyl-proteoglycan |
|---|
| Comment |
Involved in the biosynthesis of chondroitin and dermatan sulfate.
The human chondroitin synthetase is a bifunctional
glycosyltransferase, which has the 3-beta-glucuronosyltransferase
and 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175)
activities required for the synthesis of the chondroitin sulfate
disaccharide repeats. Similar chondroitin synthase 'co-polymerases'
can be found in Pasteurella multocida and Escherichia coli. There is
also another human protein with apparently only the
3-beta-glucuronosyltransferase activity. |
|---|
| Pathway |
PATH: ec00532 Chondroitin sulfate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03419 N-acetylgalactosaminyl-proteoglycan
3-beta-glucuronosyltransferase |
|---|
| Genes |
HSA: 22856(CHSY1) 337876(CHSY3) 54480(CHPF2) 79586(CHPF)
PTR: 463886(CHPF2) 467777(CHSY1)
MCC: 703860(CHPF) 715139
MMU: 100910(Chpf2) 269941(Chsy1) 74241(Chpf) 78923(Chsy3)
RNO: 291577(Chsy3) 292999(Chsy1) 296733(RGD1306404) 316533(Chpf)
CFA: 481492(CHSY3) 482807(CHPF2) 488538(CHPF) 488704(CHSY1)
BTA: 281690(CHSY1) 512538(CHPF2) 528149(CHSY3) 540002(CHPF)
SSC: 100156261
ECB: 100057477(CHSY1) 100059511 100072984
MDO: 100010621 100015571 100020781
OAA: 100075185
GGA: 415521(CHSY1) 415598(CHSY3) 769112(CHPF)
TGU: 100222602 100223757 100225582 100229326
XTR: 100036707
DRE: 100000654 324407(chys1) 565504
BFO: BRAFLDRAFT_124328
SPU: 578984
DME: Dmel_CG4351 Dmel_CG9220
DPO: Dpse_GA18127 Dpse_GA22578
DAN: Dana_GF22250
DER: Dere_GG19389
DPE: Dper_GL16444
DSE: Dsec_GM22544
DSI: Dsim_GD15794
DYA: Dyak_GE16036
DGR: Dgri_GH11859
DMO: Dmoj_GI15636
AGA: AgaP_AGAP001010
AAG: AaeL_AAEL006466
CQU: CpipJ_CPIJ015759
AME: 413549
TCA: 656073
API: 100158987 100166045
ISC: IscW_ISCW013435
CEL: PAR2.4(mig-22)
CBR: CBG03828
BMY: Bm1_19700 Bm1_44390
NVE: NEMVE_v1g240106 NEMVE_v1g94211
HMG: 100199409
PMU: PM0775
 |
|---|
| Structures |
PDB: 2Z86 2Z87 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11514575]
Kitagawa H, Uyama T, Sugahara K.
Molecular cloning and expression of a human chondroitin synthase.
J. Biol. Chem. 276 (2001) 38721-6.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10818104]
DeAngelis PL, Padgett-McCue AJ.
Identification and molecular cloning of a chondroitin synthase from
Pasteurella multocida type F.
J. Biol. Chem. 275 (2000) 24124-9.
Pasteurella multocida [GN:pmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:11943778]
Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K.
Molecular cloning and characterization of chondroitin polymerase
from Escherichia coli strain K4.
J. Biol. Chem. 277 (2002) 21567-75.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:12145278]
Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, Inaba
N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H.
Molecular cloning and characterization of a novel chondroitin
sulfate glucuronyltransferase that transfers glucuronic acid to
N-acetylgalactosamine.
J. Biol. Chem. 277 (2002) 38179-88.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.226
IUBMB Enzyme Nomenclature: 2.4.1.226
ExPASy - ENZYME nomenclature database: 2.4.1.226
BRENDA, the Enzyme Database: 2.4.1.226
CAS: 269077-98-7 |
|---|
