KEGG   ENZYME: 2.4.1.226Help
Entry
EC 2.4.1.226                Enzyme                                 

Name
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase;
chondroitin glucuronyltransferase II;
alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan [RN:R07336]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucuronate [CPD:C00167];
N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Product
UDP [CPD:C00015];
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Comment
Involved in the biosynthesis of chondroitin and dermatan sulfate. The human chondroitin synthetase is a bifunctional glycosyltransferase, which has the 3-beta-glucuronosyltransferase and 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175) activities required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli. There is also another human protein with apparently only the 3-beta-glucuronosyltransferase activity.
History
EC 2.4.1.226 created 2002
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Metabolic pathways
Orthology
K00747  
chondroitin polymerizing factor
K03419  
chondroitin polymerizing factor 2
K13499  
chondroitin sulfate synthase
K13500  
chondroitin synthase
Genes
HSA: 
22856(CHSY1) 337876(CHSY3) 54480(CHPF2) 79586(CHPF)
PTR: 
101058578(CHPF2) 467777(CHSY1) 471623(CHSY3) 743513(CHPF)
PPS: 
GGO: 
101126045(CHSY3) 101136357(CHSY1) 101144411(CHPF) 101153861(CHPF2)
PON: 
100445095(CHPF2) 100449809(CHSY1) 100455730(CHPF)
MCC: 
100423555(CHSY3) 100689486(CHPF2) 694481(CHSY1) 703860(CHPF)
MCF: 
101866114 102122122(CHPF2) 102136125(CHSY1) 102136240(CHSY3)
MMU: 
100910(Chpf2) 269941(Chsy1) 74241(Chpf) 78923(Chsy3)
RNO: 
291577(Chsy3) 292999(Chsy1) 296733(Chpf2) 316533(Chpf)
CGE: 
HGL: 
101700301(Chsy1) 101701741(Chsy3) 101703677(Chpf2) 101707555(Chpf)
TUP: 
102488411(CHPF) 102491913(CHSY3) 102495682(CHSY1) 102501664(CHPF2)
CFA: 
481492(CHSY3) 482807(CHPF2) 488539(CHPF) 488704(CHSY1)
AML: 
FCA: 
101083179(CHSY1) 101092580(CHSY3) 101097752(CHPF) 101099111(CHPF2)
PTG: 
102952320(CHSY1) 102959394(CHPF) 102969582(CHPF2) 102971026(CHSY3)
BTA: 
100616099(CHPF2) 281690(CHSY1) 528149(CHSY3) 540002(CHPF)
BOM: 
102264916(CHPF2) 102281638(CHSY1) 102281650(CHSY3) 102284379(CHPF)
PHD: 
CHX: 
102170413(CHSY3) 102179324(CHSY1) 102181823(CHPF) 102188381(CHPF2)
SSC: 
100517065(CHPF2) 100518720(CHSY3) 100520288(CHSY1) 100623047(CHPF)
CFR: 
102504589(CHSY3) 102505571(CHPF2) 102523829(CHSY1) 102524541(CHPF)
ECB: 
100057477(CHSY1) 100059511(CHPF) 100072984(CHSY3)
MYB: 
MYD: 
102757536(CHPF2) 102761493(CHPF) 102767110(CHSY3) 102768473(CHSY1)
PALE: 
102881434(CHPF) 102890106(CHPF2) 102890373(CHSY1) 102895704 102897068(CHSY3)
MDO: 
100010621(CHPF) 100015571(CHPF2) 100020781(CHSY1)
SHR: 
100913326(CHPF) 100922404(CHPF2) 100923374(CHSY1)
OAA: 
GGA: 
415521(CHSY1) 415598(CHSY3) 426039(CHPF2) 769112(CHPF)
MGP: 
100540185(CHSY1) 100544997(CHPF2) 100550036 100550164(CHSY3)
TGU: 
100222602(CHSY1) 100223757(CHSY3) 100225582(CHPF) 100229326(CHPF2)
FAB: 
101809918(CHPF) 101812023(CHPF2) 101812932(CHSY3) 101818662(CHSY1)
PHI: 
102104336(CHSY1) 102105051(CHPF) 102107624(CHSY3) 102110734(CHPF2)
APLA: 
101792856(CHPF2) 101799372(CHSY3) 101800894(CHPF) 101801430(CHSY1)
FPG: 
101911790(CHPF2) 101919161(CHSY1) 101919353(CHSY3) 101923812(CHPF)
FCH: 
102054731(CHSY1) 102054841(CHSY3) 102055615(CHPF2) 102056391(CHPF)
CLV: 
102085164(CHPF2) 102088360(CHPF) 102090190(CHSY1) 102091017(CHSY3)
ASN: 
102375772(CHSY1) 102383905(CHPF2) 102384714(CHSY3) 102388640(CHPF)
PSS: 
CMY: 
102932901(CHPF) 102938881(CHSY1) 102939048(CHSY3) 102939164(CHPF2)
ACS: 
XTR: 
100036707(chsy1) 100216189(chpf2) 100379780(chpf) 100494038(chsy3)
DRE: 
100000654(chpf2) 100331155(chpfa) 324407(chsy1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346351 102348174(CHPF2) 102357727(CHSY3) 102363926(CHPF) 102366930(CHSY1)
BFO: 
CIN: 
SPU: 
578984 579341(CHSY1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
100579040 413549(GB13893)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_PAR2.4(mig-22) CELE_T24D1.1(sqv-5)
CBR: 
CBG03828(Cbr-sqv-5) CBG06915(Cbr-mig-22)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
AQU: 
GSL: 
PMU: 
FBL: 
CPH: 
 » show all
Taxonomy
Reference
1  [PMID:11514575]
  Authors
Kitagawa H, Uyama T, Sugahara K.
  Title
Molecular cloning and expression of a human chondroitin synthase.
  Journal
J. Biol. Chem. 276 (2001) 38721-6.
  Organism
Homo sapiens
  Sequence
[hsa:22856]
Reference
2  [PMID:10818104]
  Authors
DeAngelis PL, Padgett-McCue AJ.
  Title
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.
  Journal
J. Biol. Chem. 275 (2000) 24124-9.
  Organism
Pasteurella multocida
  Sequence
[pmu:PM0775]
Reference
3  [PMID:11943778]
  Authors
Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K.
  Title
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.
  Journal
J. Biol. Chem. 277 (2002) 21567-75.
  Organism
Escherichia coli
  Sequence
[up:Q8L0V4]
Reference
4  [PMID:12145278]
  Authors
Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, Inaba N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H.
  Title
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.
  Journal
J. Biol. Chem. 277 (2002) 38179-88.
  Organism
Homo sapiens
  Sequence
[hsa:54480]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
269077-98-7

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