KEGG   ENZYME: 2.4.1.228Help
Entry
EC 2.4.1.228                Enzyme                                 

Name
lactosylceramide 4-alpha-galactosyltransferase;
Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase;
globotriaosylceramide/CD77 synthase;
histo-blood group Pk UDP-galactose;
UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03486 R05960]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Comment
For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.
History
EC 2.4.1.228 created 2002
Pathway
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K01988  
lactosylceramide 4-alpha-galactosyltransferase
Genes
HSA: 
53947(A4GALT)
PTR: 
470230(A4GALT)
PPS: 
100981788(A4GALT)
GGO: 
101148084(A4GALT)
PON: 
100172807(A4GALT)
MCC: 
710998(A4GALT)
MCF: 
102134894(A4GALT)
MMU: 
239559(A4galt)
RNO: 
63888(A4galt)
CGE: 
100770462(A4galt)
HGL: 
101717743(A4galt)
TUP: 
102482240(A4GALT)
CFA: 
481222(A4GALT)
AML: 
FCA: 
101085732(A4GALT)
PTG: 
102966914(A4GALT)
BTA: 
618369(A4GALT)
BOM: 
102281081(A4GALT)
PHD: 
102332009(A4GALT)
CHX: 
102190112(A4GALT)
SSC: 
100524987(A4GALT)
CFR: 
102519432(A4GALT)
BACU: 
LVE: 
103069366(A4GALT)
ECB: 
102150730(A4GALT)
MYB: 
102242406(A4GALT)
MYD: 
102751675(A4GALT)
PALE: 
102884849(A4GALT)
SHR: 
100925030(A4GALT)
OAA: 
100090950(A4GALT)
GGA: 
418220(CYB5R3)
MGP: 
TGU: 
FAB: 
PHI: 
102110169(A4GALT)
APLA: 
101791613(A4GALT)
FPG: 
FCH: 
CLV: 
ASN: 
102382036(A4GALT)
AMJ: 
102568489(A4GALT)
PSS: 
102459009(A4GALT)
CMY: 
102947245(A4GALT)
ACS: 
XTR: 
100495236(a4galt)
LCM: 
DME: 
Dmel_CG17223(alpha4GT1) Dmel_CG5878(alpha4GT2)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0004s03940g(POPTRDRAFT_856311) POPTR_0006s09980g POPTR_0011s04750g(POPTRDRAFT_890037) POPTR_0015s153201 POPTR_0016s12140g(POPTRDRAFT_257659)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0529700-01(Os04g0529700)
OBR: 
SBI: 
SORBI_02g036660(SORBIDRAFT_02g036660) SORBI_06g023350(SORBIDRAFT_06g023350)
ZMA: 
SITA: 
ATR: 
s00009p00267920(AMTR_s00009p00267920) s00029p00235780(AMTR_s00029p00235780)
SMO: 
PPP: 
BPG: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:3099784]
  Authors
Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B.
  Title
Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.
  Journal
Biochem. Biophys. Res. Commun. 141 (1986) 84-91.
  Organism
Homo sapiens
Reference
2  [PMID:10747952]
  Authors
Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H.
  Title
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.
  Journal
J. Biol. Chem. 275 (2000) 16723-9.
  Organism
Homo sapiens
  Sequence
[hsa:53947]
Reference
3  [PMID:10748143]
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.
  Journal
J. Biol. Chem. 275 (2000) 15152-6.
  Organism
Homo sapiens
  Sequence
[hsa:53947]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52725-57-2

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