KEGG   ENZYME: 2.4.1.228Help
Entry
EC 2.4.1.228                Enzyme                                 
Name
lactosylceramide 4-alpha-galactosyltransferase;
Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase;
globotriaosylceramide/CD77 synthase;
histo-blood group Pk UDP-galactose;
UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03486 R05960]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Comment
For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.
Pathway
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K01988  
lactosylceramide 4-alpha-galactosyltransferase
Genes
HSA: 
53947(A4GALT)
PTR: 
470230(A4GALT)
PPS: 
100981788(A4GALT)
GGO: 
101148084(A4GALT)
PON: 
100172807(A4GALT)
MCC: 
710998(A4GALT)
MMU: 
239559(A4galt)
RNO: 
63888(A4galt)
CFA: 
481222(A4GALT)
AML: 
FCA: 
101085732(A4GALT)
BTA: 
618369
SSC: 
100524987
SHR: 
100925030(A4GALT)
OAA: 
100090950
GGA: 
418223(A4GALT)
MGP: 
100550373
TGU: 
100222013 100224928 100227822
ACS: 
100558212
XTR: 
100495236
DME: 
Dmel_CG17223(alpha4GT1) Dmel_CG5878(alpha4GT2)
DPO: 
Dpse_GA14400 Dpse_GA26016
DAN: 
Dana_GF14753 Dana_GF16775
DER: 
Dere_GG11427 Dere_GG24467
DPE: 
Dper_GL19576 Dper_GL19577
DSE: 
Dsec_GM10267 Dsec_GM18175
DSI: 
Dsim_GD11999 Dsim_GD21237
DWI: 
Dwil_GK15176
DYA: 
Dyak_GE14957 Dyak_GE23622
DGR: 
Dgri_GH10340 Dgri_GH13059
DMO: 
Dmoj_GI17430 Dmoj_GI17680 Dmoj_GI21127 Dmoj_GI21138
DVI: 
Dvir_GJ10906 Dvir_GJ10917 Dvir_GJ17463
AGA: 
AgaP_AGAP008258
AAG: 
AaeL_AAEL001895 AaeL_AAEL001900 AaeL_AAEL005019
CQU: 
CpipJ_CPIJ001089 CpipJ_CPIJ001090 CpipJ_CPIJ001091 CpipJ_CPIJ019406 CpipJ_CPIJ019517
AME: 
727510
NVI: 
100115564(NV17533)
TCA: 
658448
API: 
100570817 100571406
PHU: 
Phum_PHUM591580
ISC: 
IscW_ISCW006262 IscW_ISCW006436
ATH: 
AT1G61050 AT2G38150 AT3G09020
ALY: 
ARALYDRAFT_478210 ARALYDRAFT_669657 ARALYDRAFT_893425 ARALYDRAFT_903014
GMX: 
100781975 100789203 100812965
MTR: 
MTR_2g013300 MTR_7g067510
CSV: 
101220697 101227553
RCU: 
RCOM_0935520 RCOM_1150980
POP: 
POPTR_257659 POPTR_856311 POPTR_890037
VVI: 
100247748 100853373
OSA: 
4336475
DOSA: 
Os04t0529700-01(Os04g0529700)
SBI: 
SORBI_02g036660(SORBIDRAFT_02g036660) SORBI_06g023350(SORBIDRAFT_06g023350)
ZMA: 
100283564
PPP: 
PHYPADRAFT_221508
 » show all
Taxonomy
Reference
1  [PMID:3099784]
  Authors
Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B.
  Title
Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.
  Journal
Biochem. Biophys. Res. Commun. 141 (1986) 84-91.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:10747952]
  Authors
Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H.
  Title
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.
  Journal
J. Biol. Chem. 275 (2000) 16723-9.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:10748143]
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.
  Journal
J. Biol. Chem. 275 (2000) 15152-6.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52725-57-2
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