KEGG   ENZYME: 2.4.1.228Help
Entry
EC 2.4.1.228                Enzyme                                 

Name
lactosylceramide 4-alpha-galactosyltransferase;
Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase;
globotriaosylceramide/CD77 synthase;
histo-blood group Pk UDP-galactose;
UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03486 R05960]
Reaction(KEGG)
R03486 R05960(G);
(other) R11375(G) R11376(G) R11377(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Comment
For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.
History
EC 2.4.1.228 created 2002
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K01988  lactosylceramide 4-alpha-galactosyltransferase
Genes
HSA: 53947(A4GALT)
PTR: 470230(A4GALT)
PPS: 100981788(A4GALT)
GGO: 101148084(A4GALT)
PON: 100172807(A4GALT)
NLE: 100582945(A4GALT)
MCC: 710998(A4GALT)
MCF: 102134894(A4GALT)
CSAB: 103223426(A4GALT)
RRO: 104668998(A4GALT)
RBB: 108514019(A4GALT)
CJC: 100399091 100399258(A4GALT)
SBQ: 101049376(A4GALT)
MMU: 239559(A4galt)
RNO: 63888(A4galt)
CGE: 100770462(A4galt)
NGI: 103743444(A4galt)
HGL: 101717743(A4galt)
CCAN: 109693113(A4galt)
OCU: 100347783(A4GALT)
TUP: 102482240(A4GALT)
CFA: 481222(A4GALT)
AML: 100473471(A4GALT)
UMR: 103674056(A4GALT)
ORO: 101378243(A4GALT)
FCA: 101085732(A4GALT)
PTG: 102966914(A4GALT)
AJU: 106967275(A4GALT)
BTA: 618369(A4GALT)
BOM: 102281081(A4GALT)
BIU: 109559887(A4GALT)
PHD: 102332009(A4GALT)
CHX: 102190112(A4GALT)
OAS: 101106675(A4GALT)
SSC: 100524987(A4GALT)
CFR: 102519432(A4GALT)
CDK: 105091872(A4GALT)
BACU: 103010830(A4GALT) 103013262
LVE: 103069366(A4GALT)
OOR: 101275372(A4GALT)
ECB: 102150730(A4GALT)
EPZ: 103560176(A4GALT)
EAI: 106845936(A4GALT)
MYB: 102242406(A4GALT)
MYD: 102751675(A4GALT)
HAI: 109371482(A4GALT)
RSS: 109436675(A4GALT)
PALE: 102884849(A4GALT)
LAV: 100654825(A4GALT)
TMU: 101343100
MDO: 100017110(A4GALT)
SHR: 100925030(A4GALT)
OAA: 100090950(A4GALT)
GGA: 418223(A4GALT)
MGP: 100550373(A4GALT)
CJO: 107317221(A4GALT)
APLA: 101791613(A4GALT)
ACYG: 106038268(A4GALT)
GFR: 102036341 102038089(A4GALT)
PHI: 102110169(A4GALT) 106628858
CCW: 104696146(A4GALT)
FPG: 101921227(A4GALT) 101921402
FCH: 102057844(A4GALT) 102058020
ASN: 102382036(A4GALT)
AMJ: 102568489(A4GALT)
PSS: 102459009(A4GALT)
CMY: 102947245(A4GALT)
CPIC: 101950887(A4GALT)
ACS: 100558212(a4galt)
PVT: 110087161(A4GALT)
GJA: 107120303(A4GALT)
XLA: 108710180(a4galt.L)
XTR: 100495236(a4galt)
NPR: 108804610(A4GALT)
DSI: Dsimw501_GD11999(Dsim_GD11999) Dsimw501_GD21237(Dsim_GD21237)
MDE: 101898147
AME: 727510
BIM: 100740409
BTER: 100650768
SOC: 105196183
AEC: 105145775
HST: 105190591
LHU: 105678152
PGC: 109860132
NVI: 100115564
TCA: 658448
NVL: 108558122
PRAP: 111002820
DNX: 107166115
LJA: Lj1g3v2311890.1(Lj1g3v2311890.1) Lj1g3v2311900.1(Lj1g3v2311900.1) Lj6g3v2044530.1(Lj6g3v2044530.1)
LANG: 109329644
OSA: 4336475
DOSA: Os04t0529700-01(Os04g0529700)
OBR: 102717891
BDI: 100831105
ATS: 109732097(LOC109732097)
SBI: 8082872
ZMA: 100283564
SITA: 101786409
MUS: 103968640
DCT: 110109954
AOF: 109820034
SMO: SELMODRAFT_419460(GT32A2)
 » show all
Taxonomy
Reference
1  [PMID:3099784]
  Authors
Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B.
  Title
Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.
  Journal
Biochem. Biophys. Res. Commun. 141 (1986) 84-91.
Reference
2  [PMID:10747952]
  Authors
Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H.
  Title
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.
  Journal
J. Biol. Chem. 275 (2000) 16723-9.
  Sequence
[hsa:53947]
Reference
3  [PMID:10748143]
  Authors
Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.
  Title
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.
  Journal
J. Biol. Chem. 275 (2000) 15152-6.
  Sequence
[hsa:53947]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.228
IUBMB Enzyme Nomenclature: 2.4.1.228
ExPASy - ENZYME nomenclature database: 2.4.1.228
BRENDA, the Enzyme Database: 2.4.1.228
CAS: 52725-57-2

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