KEGG   ENZYME: 2.4.1.232Help
Entry
EC 2.4.1.232                Enzyme                                 

Name
initiation-specific alpha-1,6-mannosyltransferase;
alpha-1,6-mannosyltransferase;
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase;
GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase;
glycolipid 6-alpha-mannosyltransferase;
GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase
Reaction(IUBMB)
Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage
Reaction(KEGG)
(other) R06986(G) R08599(G)
Show
Comment
Requires Mn2+. In Saccharomyces cerevisiae, this enzyme catalyses an essential step in the outer chain elongation of N-linked oligosaccharides. Man8GlcNAc and Man9GlcNAc are equally good substrates.
History
EC 2.4.1.232 created 2004
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K05528  alpha 1,6-mannosyltransferase
K05529  mannan polymerase complexes MNN9 subunit
Genes
BFO: BRAFLDRAFT_123269
HRO: HELRODRAFT_153976
CRG: 105320143
OBI: 106869556
LAK: 106162184 106173809
VCN: VOLCADRAFT_96511
MNG: MNEG_11989 MNEG_3415 MNEG_9768
CME: CYME_CMT636C
GSL: Gasu_17110 Gasu_59940
SCE: YGL038C(OCH1) YPL050C(MNN9)
KMX: KLMA_10184(och1) KLMA_40267(OCH1) KLMA_70378(MNN9)
NCS: NCAS_0A01880(NCAS0A01880) NCAS_0B02440(NCAS0B02440) NCAS_0C02330(NCAS0C02330)
NDI: NDAI_0C05250(NDAI0C05250) NDAI_0D03810(NDAI0D03810) NDAI_0E03020(NDAI0E03020)
TPF: TPHA_0F00500(TPHA0F00500) TPHA_0K01810(TPHA0K01810) TPHA_0L01370(TPHA0L01370)
TBL: TBLA_0B00380(TBLA0B00380) TBLA_0C04290(TBLA0C04290) TBLA_0H03340(TBLA0H03340)
TDL: TDEL_0B01370(TDEL0B01370) TDEL_0F02760(TDEL0F02760)
KAF: KAFR_0F03660(KAFR0F03660) KAFR_0H01390(KAFR0H01390)
CAUR: QG37_00377
SLB: AWJ20_134(HOC1) AWJ20_191(MNN9)
NCR: NCU00609(och-1) NCU02635
NTE: NEUTE1DRAFT126859(NEUTE1DRAFT_126859) NEUTE1DRAFT91925(NEUTE1DRAFT_91925)
ANG: ANI_1_606064(An07g04940) ANI_1_624034(An03g05010)
SPO: SPAC1006.05c(och1) SPAC4F10.10c(mnn9)
SMIN: v1.2.008337.t1(symbB.v1.2.008337.t1) v1.2.008337.t2(symbB.v1.2.008337.t2) v1.2.009943.t1(symbB.v1.2.009943.t1) v1.2.035750.t1(symbB.v1.2.035750.t1)
 » show all
Taxonomy
Reference
1  [PMID:2644248]
  Authors
Romero PA, Herscovics A.
  Title
Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of alpha-1,6-mannosyltransferase which initiates outer chain formation.
  Journal
J. Biol. Chem. 264 (1989) 1946-50.
Reference
2  [PMID:1820199]
  Authors
Reason AJ, Dell A, Romero PA, Herscovics A.
  Title
Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae.
  Journal
Glycobiology. 1 (1991) 387-91.
Reference
3  [PMID:8253757]
  Authors
Nakanishi-Shindo Y, Nakayama K, Tanaka A, Toda Y, Jigami Y.
  Title
Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.
  Journal
J. Biol. Chem. 268 (1993) 26338-45.
  Sequence
[sce:YGL038C]
Reference
4  [PMID:12784644]
  Authors
Yamamoto K, Okamoto M, Yoko-o T, Jigami Y.
  Title
Salt stress induces the expression of Schizosaccharomyces pombe och1+, which encodes an initiation-specific alpha-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins.
  Journal
Biosci. Biotechnol. Biochem. 67 (2003) 927-9.
  Sequence
Reference
5  [PMID:11754484]
  Authors
Cui Z, Horecka J, Jigami Y.
  Title
Cdc4 is involved in the transcriptional control of OCH1, a gene encoding alpha-1,6-mannosyltransferase in Saccharomyces cerevisiae.
  Journal
Yeast. 19 (2002) 69-77.
Reference
6
  Authors
Tsukahara, K., Watanabe, T., Yoko-o, T. and Chigami, Y.
  Title
Schizosaccharomyces pombe och1+ gene encoding alpha-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation.
  Journal
Jpn. Kokai Tokkyo Koho Koho (2001) 11.
Reference
7  [PMID:9276464]
  Authors
Nakayama K, Nakanishi-Shindo Y, Tanaka A, Haga-Toda Y, Jigami Y.
  Title
Substrate specificity of alpha-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae.
  Journal
FEBS. Lett. 412 (1997) 547-50.
Reference
8  [PMID:8797833]
  Authors
Suzuki A, Shibata N, Suzuki M, Saitoh F, Takata Y, Oshie A, Oyamada H, Kobayashi H, Suzuki S, Okawa Y.
  Title
Characterization of alpha-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan.
  Journal
Eur. J. Biochem. 240 (1996) 37-44.
Reference
9  [PMID:8146181]
  Authors
Yip CL, Welch SK, Klebl F, Gilbert T, Seidel P, Grant FJ, O'Hara PJ, MacKay VL.
  Title
Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 2723-7.
  Sequence
[sce:YPL050C]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.232
IUBMB Enzyme Nomenclature: 2.4.1.232
ExPASy - ENZYME nomenclature database: 2.4.1.232
BRENDA, the Enzyme Database: 2.4.1.232
CAS: 346003-17-6

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