| Entry |
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| Name |
mannosylfructose-phosphate synthase;
mannosylfructose-6-phosphate synthase;
MFPS
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
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| Sysname |
GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase
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| Reaction(IUBMB) |
GDP-mannose + D-fructose 6-phosphate = GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate [RN: R08947]
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| Reaction(KEGG) |
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| Substrate |
GDP-mannose [CPD: C00096];
D-fructose 6-phosphate [CPD: C00085]
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| Product |
GDP [CPD: C00035];
beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate [CPD: C18050]
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| Comment |
This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity. GDP-mannose can be replaced by ADP-mannose but with a concomitant decrease in activity. The product of this reaction is dephosphorylated by EC 3.1.3.79 (mannosylfructose-phosphate phosphatase) to form the non-reducing disaccharide mannosylfructose, which is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress. The F in the product name is used to indicate that the fructose residue of sucrose carries the substituent.
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| Orthology |
| mannosylfructose-phosphate synthase |
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| Genes |
 |
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| Reference |
|
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| Authors |
Torres LL, Salerno GL |
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| Title |
A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases. |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 14318-23. |
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| Organism |
Agrobacterium tumefaciens C58 [GN: atu] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 92480-04-1 |
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