KEGG   ENZYME: 2.4.1.267Help
Entry
EC 2.4.1.267                Enzyme                                 
Name
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase;
ALG6;
Dol-P-Glc:Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase
Reaction(IUBMB)
dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06262]
Reaction(KEGG)
R06262(G)
Show
Substrate
dolichyl beta-D-glucosyl phosphate [CPD:C01246];
D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
Product
D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:C00110]
Comment
The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase) and EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly.
Pathway
N-Glycan biosynthesis
Metabolic pathways
Orthology
K03848  
alpha-1,3-glucosyltransferase
Genes
HSA: 
29929(ALG6)
PTR: 
456906(ALG6)
PPS: 
100979540(ALG6)
GGO: 
101136901(ALG6)
PON: 
100174089(ALG6)
MCC: 
696323(ALG6)
MMU: 
320438(Alg6)
RNO: 
362547(Alg6)
CFA: 
609974(ALG6)
AML: 
100474628(ALG6)
FCA: 
101082423(ALG6)
BTA: 
510138(ALG6)
SSC: 
100521457(ALG6)
ECB: 
100070118(ALG6)
SHR: 
100914646(ALG6)
OAA: 
100087624(ALG6)
GGA: 
395078(ALG6)
MGP: 
100550656
TGU: 
100225071(ALG6)
ACS: 
100566228
XLA: 
446684(alg6)
XTR: 
496948(alg6)
DRE: 
445327(alg6)
TRU: 
101071162
OLA: 
101155182
BFO: 
BRAFLDRAFT_227830
CIN: 
100177063
SPU: 
591591
DME: 
Dmel_CG5091(gny)
DPO: 
Dpse_GA18653
DAN: 
Dana_GF15776
DER: 
Dere_GG10119
DPE: 
Dper_GL19144
DSE: 
Dsec_GM18280
DSI: 
Dsim_GD23688
DWI: 
Dwil_GK18996
DYA: 
Dyak_GE18933
DGR: 
Dgri_GH13362
DMO: 
Dmoj_GI18289
DVI: 
Dvir_GJ15406
AGA: 
AgaP_AGAP008946
AAG: 
AaeL_AAEL006438
CQU: 
CpipJ_CPIJ004202
TCA: 
660992
PHU: 
Phum_PHUM448540
ISC: 
IscW_ISCW004503
CEL: 
CELE_C08B11.8(C08B11.8)
CBR: 
CBG13345
TSP: 
Tsp_07541
SMM: 
Smp_096910
NVE: 
NEMVE_v1g165140
HMG: 
100212807
TAD: 
TRIADDRAFT_28993
AQU: 
100637175
ATH: 
AT5G38460
ALY: 
ARALYDRAFT_494131
GMX: 
100809881
CSV: 
101213368
RCU: 
RCOM_1725550
POP: 
POPTR_266210 POPTR_555846
VVI: 
100241202
OSA: 
4342475
DOSA: 
Os07t0164500-01(Os07g0164500)
BDI: 
100834235
ZMA: 
100278369
SMO: 
SELMODRAFT_452924(GT57A1)
PPP: 
PHYPADRAFT_149102
CRE: 
CHLREDRAFT_36194(GTR21)
VCN: 
VOLCADRAFT_62003
CME: 
CMH028C
SCE: 
YOR002W(ALG6)
AGO: 
AGOS_ACR004W
ERC: 
Ecym_3027
KLA: 
KLLA0D01221g
LTH: 
KLTH0C11176g
PPA: 
PAS_chr2-1_0549
VPO: 
Kpol_1037p27
ZRO: 
ZYRO0C07744g
CGR: 
CAGL0E02629g
NCS: 
NCAS_0D02160(NCAS0D02160)
NDI: 
NDAI_0C02630(NDAI0C02630)
TPF: 
TPHA_0J00350(TPHA0J00350)
TBL: 
TBLA_0G00970(TBLA0G00970)
TDL: 
TDEL_0G04470(TDEL0G04470)
KAF: 
KAFR_0A05070(KAFR0A05070)
DHA: 
DEHA2E21428g
PIC: 
PICST_29880(ALG6)
PGU: 
PGUG_03534
LEL: 
LELG_03132
CAL: 
CaO19.1843(ALG6) CaO19.9402(ALG6)
CTP: 
CTRG_00695
CDU: 
CD36_32420
COT: 
CORT_0D06230
YLI: 
YALI0D17028g
CLU: 
CLUG_04659
NCR: 
NCU03317
PAN: 
PODANSg5667
TTT: 
THITE_2121621
MTM: 
MYCTH_2294795
MGR: 
MGG_09310
FGR: 
FG05607.1
NHE: 
NECHADRAFT_95467
VAL: 
VDBG_04725
ANI: 
AN4864.2
NFI: 
NFIA_069450
AFM: 
AFUA_3G07700
AOR: 
AOR_1_720084(AO090020000410)
AFV: 
AFLA_100040
ACT: 
ACLA_035660
PCS: 
Pc15g01240
CIM: 
CIMG_02332
CPW: 
CPC735_039780
URE: 
UREG_01418
ABE: 
ARB_06600
TVE: 
TRV_04803
AJE: 
HCAG_01909
PNO: 
SNOG_15246
PTE: 
PTT_11965
ZTR: 
MYCGRDRAFT_53203
TML: 
GSTUM_00001621001
SPO: 
SPBC342.01c(alg6)
LBC: 
LACBIDRAFT_399393(ALG6)
MPR: 
MPER_10344
CCI: 
CC1G_11710
SCM: 
SCHCODRAFT_66786
MGL: 
MGL_2343
NGR: 
NAEGRDRAFT_29661
DDI: 
DDB_G0283841(alg6)
DPP: 
DICPUDRAFT_43700
CPV: 
cgd4_3120
CHO: 
Chro.40356
TET: 
TTHERM_00500810
PTM: 
GSPATT00015853001
PTI: 
PHATR_44117
TPS: 
THAPSDRAFT_5389
PIF: 
PITG_05541
 » show all
Taxonomy
Reference
1  [PMID:8877369]
  Authors
Reiss G, te Heesen S, Zimmerman J, Robbins PW, Aebi M
  Title
Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway.
  Journal
Glycobiology. 6 (1996) 493-8.
Reference
2  [PMID:6423630]
  Authors
Runge KW, Huffaker TC, Robbins PW
  Title
Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway.
  Journal
J. Biol. Chem. 259 (1984) 412-7.
Reference
3  [PMID:14517965]
  Authors
Westphal V, Xiao M, Kwok PY, Freeze HH
  Title
Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic.
  Journal
Hum. Mutat. 22 (2003) 420-1.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system