KEGG   ENZYME: 2.4.1.267Help
Entry
EC 2.4.1.267                Enzyme                                 

Name
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase;
ALG6;
Dol-P-Glc:Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase
Reaction(IUBMB)
dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06262]
Reaction(KEGG)
R06262(G)
Show
Substrate
dolichyl beta-D-glucosyl phosphate [CPD:C01246];
D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
Product
D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:C00110]
Comment
The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase) and EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly.
History
EC 2.4.1.267 created 2011, modified 2012
Pathway
N-Glycan biosynthesis
Metabolic pathways
Orthology
K03848  
alpha-1,3-glucosyltransferase
Genes
HSA: 
29929(ALG6)
PTR: 
456906(ALG6)
PPS: 
100979540(ALG6)
GGO: 
101136901(ALG6)
PON: 
100174089(ALG6)
NLE: 
100595734(ALG6)
MCC: 
696323(ALG6)
MCF: 
CJC: 
100413929(ALG6)
MMU: 
320438(Alg6)
RNO: 
362547(Alg6)
CGE: 
100753783(Alg6)
NGI: 
103732484(Alg6)
HGL: 
101713296(Alg6)
OCU: 
100357591(ALG6)
TUP: 
102503200(ALG6)
CFA: 
609974(ALG6)
AML: 
100474628(ALG6)
UMR: 
103663065(ALG6)
FCA: 
101082423(ALG6)
PTG: 
102962752(ALG6)
BTA: 
510138(ALG6)
BOM: 
102274203(ALG6)
PHD: 
102329022(ALG6)
CHX: 
102184686(ALG6)
OAS: 
101108436(ALG6)
SSC: 
100521457(ALG6)
CFR: 
102521650(ALG6)
BACU: 
103007399(ALG6)
LVE: 
103088486(ALG6)
ECB: 
100070118(ALG6)
MYB: 
102250476(ALG6)
MYD: 
102753718(ALG6)
PALE: 
102877923(ALG6)
SHR: 
100914646(ALG6)
OAA: 
100087624(ALG6)
GGA: 
395078(ALG6)
MGP: 
APLA: 
101791177(ALG6)
TGU: 
100225071(ALG6)
FAB: 
101821337(ALG6)
PHI: 
102099752(ALG6)
FPG: 
101921068(ALG6)
FCH: 
102047964(ALG6)
CLV: 
102097072(ALG6)
ASN: 
102369593(ALG6)
AMJ: 
102560193(ALG6)
PSS: 
102459075(ALG6)
CMY: 
102934394(ALG6)
ACS: 
100566228(alg6)
PBI: 
103053033(ALG6)
XLA: 
446684(alg6)
XTR: 
496948(alg6)
DRE: 
445327(alg6)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103188824(alg6)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552184(GB12138)
TCA: 
BMOR: 
PHU: 
ISC: 
CEL: 
CELE_C08B11.8(C08B11.8)
CBR: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os07t0164500-01(Os07g0164500)
OBR: 
BDI: 
ZMA: 
SITA: 
PDA: 
ATR: 
s00029p00242660(AMTR_s00029p00242660)
SMO: 
PPP: 
CRE: 
VCN: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YOR002W(ALG6)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0D02160(NCAS0D02160)
NDI: 
NDAI_0C02630(NDAI0C02630)
TPF: 
TPHA_0J00350(TPHA0J00350)
TBL: 
TBLA_0G00970(TBLA0G00970)
TDL: 
TDEL_0G04470(TDEL0G04470)
KAF: 
KAFR_0A05070(KAFR0A05070)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_720084(AO090020000410)
ANG: 
ANI_1_1736024(An02g12630)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT74153(AGABI1DRAFT_74153)
ABV: 
AGABI2DRAFT206973(AGABI2DRAFT_206973)
CPUT: 
SLA: 
MGL: 
PGR: 
MLR: 
DDI: 
DPP: 
ACAN: 
CPV: 
CHO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:8877369]
  Authors
Reiss G, te Heesen S, Zimmerman J, Robbins PW, Aebi M
  Title
Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway.
  Journal
Glycobiology. 6 (1996) 493-8.
  Sequence
[sce:YOR002W]
Reference
2  [PMID:6423630]
  Authors
Runge KW, Huffaker TC, Robbins PW
  Title
Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway.
  Journal
J. Biol. Chem. 259 (1984) 412-7.
Reference
3  [PMID:14517965]
  Authors
Westphal V, Xiao M, Kwok PY, Freeze HH
  Title
Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic.
  Journal
Hum. Mutat. 22 (2003) 420-1.
  Sequence
[hsa:29929]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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