| Entry |
|
|---|
| Name |
fucosylgalactoside 3-alpha-galactosyltransferase;
UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose
alpha-D-galactosyltransferase;
UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose
3-alpha-D-galactosyltransferase;
[blood group substance] alpha-galactosyltransferase;
blood-group substance B-dependent galactosyltransferase;
glycoprotein-fucosylgalactoside alpha-galactosyltransferase;
histo-blood group B transferase;
histo-blood substance B-dependent galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside
3-alpha-D-galactosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside
3-alpha-D-galactosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP +
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R
(where R can be OH, an oligosaccharide or a glycoconjugate)
[RN:R04548] |
|---|
| Reaction(KEGG) |
R04548 > R06029(G) R06168(G) R06190(G)
 |
|---|
| Substrate |
UDP-galactose [CPD:C00052];
alpha-L-fucosyl-(1->2)-D-galactosyl-R [CPD:C04648] |
|---|
| Product |
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R
(where R can be OH, an oligosaccharide;
a glycoconjugate) |
|---|
| Comment |
Acts on blood group substance, and can use a number of
2-fucosyl-galactosides as acceptors. |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00709 histo-blood group ABO system transferase |
|---|
| Genes |
HSA: 28(ABO)
PTR: 450164(ABO)
MCC: 722252(ABO)
MMU: 80908(Abo)
RNO: 296504(Abo_predicted) 65270(Abo)
CFA: 491265(ABO)
BTA: 515340(ABO)
SSC: 396713(A)
ECB: 100058033 100058525
OAA: 100075215
XLA: 495825
XTR: 549437(abo)
 |
|---|
| Structures |
PDB: 1R7U 1R7X 1R80 1R82 2A8W 2PGV 2PGY 2RIT 2RIX 2RIY
2RIZ 2RJ0 2RJ1 2RJ4 2RJ5 2RJ6 2RJ7 2RJ8 2RJ9 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:16742598]
Race C, Ziderman D, Watkins WM.
An alpha-d-galactosyltransferase associated with the blood-group B
character.
Biochem. J. 107 (1968) 733-735.
Homo sapiens [GN:hsa], Papio sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.37
IUBMB Enzyme Nomenclature: 2.4.1.37
ExPASy - ENZYME nomenclature database: 2.4.1.37
BRENDA, the Enzyme Database: 2.4.1.37
CAS: 37257-33-3 |
|---|
