KEGG   ENZYME: 2.4.1.38Help
Entry
EC 2.4.1.38                 Enzyme                                 

Name
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose---glycoprotein galactosyltransferase;
glycoprotein 4-beta-galactosyl-transferase;
beta-N-acetyl-beta1-4-galactosyltransferase;
thyroid glycoprotein beta-galactosyltransferase;
glycoprotein beta-galactosyltransferase;
thyroid galactosyltransferase;
uridine diphosphogalactose-glycoprotein galactosyltransferase;
beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase;
GalT;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide [RN:R04495]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminylglycopeptide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Comment
Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase).
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Metabolic pathways
Orthology
K07966  
beta-1,4-galactosyltransferase 1
K07967  
beta-1,4-galactosyltransferase 2
K07968  
beta-1,4-galactosyltransferase 3
Genes
HSA: 
2683(B4GALT1) 8703(B4GALT3) 8704(B4GALT2)
PTR: 
100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 
100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3)
GGO: 
101133326(B4GALT2) 101138982(B4GALT1) 101152694(B4GALT3)
PON: 
100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1)
MCC: 
703541(B4GALT1) 704038(B4GALT2) 719920(B4GALT3)
MCF: 
102115300(B4GALT2) 102123574(B4GALT3) 102131044(B4GALT1)
MMU: 
14595(B4galt1) 53418(B4galt2) 57370(B4galt3)
RNO: 
24390(B4galt1) 313536(B4galt2) 494342(B4galt3)
CGE: 
100689346(B4galt3) 100689430(Beta4galt-1) 100689434(B4galt2)
HGL: 
101702700(B4galt3) 101718811(B4galt2) 101721414(B4galt1)
TUP: 
102470655(B4GALT1) 102489782(B4GALT2) 102501629(B4GALT3)
CFA: 
476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3)
AML: 
FCA: 
101084809(B4GALT2) 101089738(B4GALT3) 101100927
BTA: 
100125390(B4GALT2) 281781(B4GALT1) 515771(B4GALT3)
BOM: 
102269762(B4GALT1) 102273575(B4GALT3) 102283249(B4GALT2)
PHD: 
102317609(B4GALT2) 102321948(B4GALT1) 102343232(B4GALT3)
CHX: 
100860927(B4GALT1) 102191101(B4GALT2) 102191287(B4GALT3)
SSC: 
100154856(B4GALT3) 100511655(B4GALT1) 100514465 100736821(B4GALT2)
CFR: 
102509909 102516080(B4GALT2) 102517623(B4GALT1) 102523348(B4GALT3)
ECB: 
100065936 100066144(B4GALT3) 100066149(B4GALT2) 100068209(B4GALT1)
MYB: 
102240062(B4GALT1) 102245477(B4GALT3) 102248727(B4GALT2)
MDO: 
SHR: 
OAA: 
GGA: 
396121(B4GALT1) 396122(B4GALT2) 418342(B4GALT3)
MGP: 
TGU: 
100219809 100223650(B4GALT1) 100230857(B4GALT2)
FAB: 
101805871(B4GALT2) 101807052(B4GALT1) 101809643
PHI: 
102106294(B4GALT2) 102108330 102109081(B4GALT1)
APLA: 
101792630 101792817(B4GALT1) 101802590(B4GALT2)
FPG: 
101910439(B4GALT3) 101915824 101916596(B4GALT2) 101918852(B4GALT1)
FCH: 
102046112(B4GALT1) 102051290 102056545(B4GALT2) 102057757(B4GALT3)
CLV: 
102088289(B4GALT1) 102088677(B4GALT2) 102094059(B4GALT3)
ASN: 
102370415 102372956(B4GALT1) 102376584(B4GALT2) 102388067(B4GALT3)
PSS: 
102448865(B4GALT3) 102459690(B4GALT1) 102461193
ACS: 
XLA: 
100190782(b4galt2) 379106(MGC52827) 414540 446718(b4galt3) 496041
XTR: 
100145518(b4galt1.1) 100486704 100492356(b4galt2) 448369(b4galt3) 549418(b4galt1.2)
DRE: 
100148828 550425(b4galt1) 556544(fd56f09) 561756 768123
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CIN: 
CEL: 
CBR: 
CBG22165(Cbr-bre-4)
LOA: 
 » show all
Taxonomy
Reference
1  [PMID:6784450]
  Authors
Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL.
  Title
Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 52 (1981) 23-175.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:6816588]
  Authors
Blanken WM, Hooghwinkel GJ, Van Den Eijnden DH.
  Title
Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum beta-N-acetyl-D-glucosaminide beta 1 leads to 4 galactosyltransferase.
  Journal
Eur. J. Biochem. 127 (1982) 547-52.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J. Biol. Chem. 260 (1985) 12927-34.
  Organism
Bos taurus [GN:bta]
Reference
4  [PMID:5726898]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase.
  Journal
J. Biol. Chem. 243 (1968) 6529-37.
  Organism
Homo sapiens [GN:hsa], Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37237-43-7

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