KEGG   ENZYME: 2.4.1.38Help
Entry
EC 2.4.1.38                 Enzyme                                 
Name
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose---glycoprotein galactosyltransferase;
glycoprotein 4-beta-galactosyl-transferase;
beta-N-acetyl-beta1-4-galactosyltransferase;
thyroid glycoprotein beta-galactosyltransferase;
glycoprotein beta-galactosyltransferase;
thyroid galactosyltransferase;
uridine diphosphogalactose-glycoprotein galactosyltransferase;
beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase;
GalT;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide [RN:R04495]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminylglycopeptide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Comment
Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase).
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Metabolic pathways
Orthology
K07966  
beta-1,4-galactosyltransferase 1
K07967  
beta-1,4-galactosyltransferase 2
K07968  
beta-1,4-galactosyltransferase 3
Genes
HSA: 
2683(B4GALT1) 8703(B4GALT3) 8704(B4GALT2)
PTR: 
100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 
100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3)
GGO: 
101133326(B4GALT2) 101138982(B4GALT1) 101152694(B4GALT3)
PON: 
100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1)
MCC: 
703541(B4GALT1) 704038(B4GALT2) 719920(B4GALT3)
MMU: 
14595(B4galt1) 53418(B4galt2) 57370(B4galt3)
RNO: 
24390(B4galt1) 313536(B4galt2) 494342(B4galt3)
CFA: 
476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3)
AML: 
FCA: 
101084809(B4GALT2) 101089738(B4GALT3) 101100927
BTA: 
100125390(B4GALT2) 281781(B4GALT1) 515771(B4GALT3)
SSC: 
100154856 100511655(B4GALT1) 100514465
ECB: 
100065936 100066144 100066149(B4GALT2) 100068209
MDO: 
100010600 100028240 100032749 100617718
SHR: 
100917085(B4GALT3) 100918732(B4GALT2) 100929465 100934965
OAA: 
100075607 100092000
GGA: 
396121(B4GALT1) 396122(B4GALT2) 418342(B4GALT3)
MGP: 
100543545 100548019
TGU: 
100219809 100223650(B4GALT1) 100230857(B4GALT2)
ACS: 
100553459 100557158 100557558 100558708 100561064
XLA: 
100190782(b4galt2) 379106(MGC52827) 414540 446718(b4galt3) 496041
XTR: 
100145518(b4galt1.1) 100492356 448369(b4galt3) 549418(b4galt1.2)
DRE: 
100148828 550425(b4galt1) 556544(fd56f09) 561756 768123
TRU: 
101066088 101072068 101075953 101076002
OLA: 
100301598(b4gal-t2) 101159351 101162708 101171148
CIN: 
100175041
CEL: 
CELE_Y73E7A.7(bre-4)
CBR: 
CBG22165(Cbr-bre-4)
 » show all
Taxonomy
Reference
1  [PMID:6784450]
  Authors
Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL.
  Title
Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 52 (1981) 23-175.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:6816588]
  Authors
Blanken WM, Hooghwinkel GJ, Van Den Eijnden DH.
  Title
Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum beta-N-acetyl-D-glucosaminide beta 1 leads to 4 galactosyltransferase.
  Journal
Eur. J. Biochem. 127 (1982) 547-52.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J. Biol. Chem. 260 (1985) 12927-34.
  Organism
Bos taurus [GN:bta]
Reference
4  [PMID:5726898]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase.
  Journal
J. Biol. Chem. 243 (1968) 6529-37.
  Organism
Homo sapiens [GN:hsa], Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37237-43-7
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