| Entry |
|
|---|
| Name |
beta-N-acetylglucosaminylglycopeptide
beta-1,4-galactosyltransferase;
UDP-galactose---glycoprotein galactosyltransferase;
glycoprotein 4-beta-galactosyl-transferase;
beta-N-acetyl-beta1-4-galactosyltransferase;
thyroid glycoprotein beta-galactosyltransferase;
glycoprotein beta-galactosyltransferase;
thyroid galactosyltransferase;
uridine diphosphogalactose-glycoprotein galactosyltransferase;
beta-N-acetylglucosaminyl-glycopeptide
beta-1,4-galactosyltransferase;
GalT;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide
beta-1,4-galactosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide
4-beta-galactosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP +
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
[RN:R04495] |
|---|
| Reaction(KEGG) |
R04495 > R05989(G)
 |
|---|
| Substrate |
UDP-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminylglycopeptide |
|---|
| Product |
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide |
|---|
| Comment |
Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides,
glycoproteins and glycopeptides can act as acceptor. High activity
is shown towards such residues in branched-chain polysaccharides
when these are linked by beta-1,6-links to galactose residues; lower
activity towards residues linked to galactose by beta-1,3-links. A
component of EC 2.4.1.22 (lactose synthase). |
|---|
| Pathway |
PATH: ec00510 N-Glycan biosynthesis
PATH: ec00533 Keratan sulfate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00708 beta-N-acetylglucosaminylglycopeptide
beta-1,4-galactosyltransferase |
|---|
| Genes |
HSA: 2683(B4GALT1) 8703(B4GALT3) 8704(B4GALT2)
PTR: 457451(B4GALT3)
MCC: 704038(B4GALT2) 719920
MMU: 14595(B4galt1) 53418(B4galt2) 57370(B4galt3)
RNO: 24390(B4galt1) 313536(B4galt2) 494342(B4galt3)
CFA: 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3)
BTA: 100125390(B4GALT2) 281781(B4GALT1) 515771(B4GALT3)
ECB: 100066144 100066149
MDO: 100010600 100032749
OAA: 100092000
GGA: 396121(B4GALT1) 396122(B4GALT2) 418342(B4GALT3)
TGU: 100219809 100230857
XLA: 379106(MGC52827)
XTR: 448369(b4galt3) 549418(b4galt2)
DRE: 100148828(CH211-261P7.4) 561756 768123
 |
|---|
| Structures |
PDB: 1FGX 1FR8 1NF5 1NHE 1NKH 1NMM 1NQI 1OQM 1PZY 1TVY
1TW1 1TW5 1YRO 3EE5 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6784450]
Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL.
Glycosyltransferases and their use in assessing oligosaccharide
structure and structure-function relationships.
Adv. Enzymol. Relat. Areas. Mol. Biol. 52 (1981) 23-175.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6816588]
Blanken WM, Hooghwinkel GJ, Van Den Eijnden DH.
Biosynthesis of blood-group I and i substances. Specificity of
bovine colostrum beta-N-acetyl-D-glucosaminide beta 1 leads to 4
galactosyltransferase.
Eur. J. Biochem. 127 (1982) 547-52.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3932335]
Blanken WM, Van den Eijnden DH.
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R
oligosaccharide sequences on glycoconjugates. Purification and
acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha
1----3-galactosyltransferase from calf thymus.
J. Biol. Chem. 260 (1985) 12927-34.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:5726898]
Spiro MJ, Spiro RG.
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid
galactosyltransferase.
J. Biol. Chem. 243 (1968) 6529-37.
Homo sapiens [GN:hsa], Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.38
IUBMB Enzyme Nomenclature: 2.4.1.38
ExPASy - ENZYME nomenclature database: 2.4.1.38
BRENDA, the Enzyme Database: 2.4.1.38
CAS: 37237-43-7 |
|---|
