| Entry |
|
|---|
| Name |
glycoprotein-fucosylgalactoside
alpha-N-acetylgalactosaminyltransferase;
A-transferase;
histo-blood group A glycosyltransferase
(Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase);
UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-
acetylgalactosaminyltransferase;
alpha-3-N-acetylgalactosaminyltransferase;
blood-group substance alpha-acetyltransferase;
blood-group substance A-dependent acetylgalactosaminyltransferase;
fucosylgalactose acetylgalactosaminyltransferase;
histo-blood group A acetylgalactosaminyltransferase;
histo-blood group A transferase;
UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose
3-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-
galactose 3-N-acetyl-D-galactosaminyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-g
alactose 3-N-acetyl-D-galactosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-galactosamine +
glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP +
glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-
fucosyl-(1->2)]-D-galactose [RN:R04423] |
|---|
| Reaction(KEGG) |
R04423;
(other) R06167(G) R06187(G) R06191(G) R06193(G) R06197(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-galactosamine [CPD:C00203];
glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose |
|---|
| Product |
UDP [CPD:C00015];
glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-
(1,2)]-D-galactose [CPD:C06483] |
|---|
| Comment |
Acts on blood group substance, and can use a number of
2-fucosyl-galactosides as acceptors. |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00709 histo-blood group ABO system transferase |
|---|
| Genes |
HSA: 28(ABO)
PTR: 450164(ABO)
MCC: 722252(ABO)
MMU: 80908(Abo)
RNO: 296504(Abo_predicted) 65270(Abo)
CFA: 491265(ABO)
BTA: 515340(ABO)
SSC: 396713(A)
ECB: 100058033 100058525
OAA: 100075215
XLA: 495825
XTR: 549437(abo)
 |
|---|
| Structures |
PDB: 1LZ0 1LZI 1R7T 1R7V 1R7Y 1R81 1WSZ 1WT0 1WT1 1WT2
1WT3 1XZ6 1ZHJ 1ZI1 1ZI3 1ZI4 1ZI5 1ZJO 2A8W |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5661629]
Kobata A, Grollman EF, Ginsburg V.
An enzymic basis for blood type A in humans.
Arch. Biochem. Biophys. 124 (1968) 609-12.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2341371]
Takeya A, Hosomi O, Ishiura M.
Complete purification and characterization of
alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood
group A gene.
J. Biochem. (Tokyo). 107 (1990) 360-8.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6434182]
Yates AD, Feeney J, Donald AS, Watkins WM.
Characterisation of a blood-group A-active tetrasaccharide
synthesised by a blood-group B gene-specified glycosyltransferase.
Carbohydr. Res. 130 (1984) 251-60.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.40
IUBMB Enzyme Nomenclature: 2.4.1.40
ExPASy - ENZYME nomenclature database: 2.4.1.40
BRENDA, the Enzyme Database: 2.4.1.40
CAS: 9067-69-0 |
|---|
