KEGG   ENZYME: 2.4.1.41Help
Entry
EC 2.4.1.41                 Enzyme                                 
Name
polypeptide N-acetylgalactosaminyltransferase;
protein-UDP acetylgalactosaminyltransferase;
UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase;
UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase;
glycoprotein acetylgalactosaminyltransferase;
polypeptide-N-acetylgalactosamine transferase;
UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase;
UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase;
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase;
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase;
ppGalNAc-T
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide [RN:R02183]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
polypeptide [CPD:C00403]
Product
UDP [CPD:C00015];
N-acetyl-alpha-D-galactosaminyl-polypeptide
Comment
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.
Pathway
Mucin type O-Glycan biosynthesis
Metabolic pathways
Orthology
K00710  
polypeptide N-acetylgalactosaminyltransferase
Genes
HSA: 
100528030(POC1B-GALNT4) 11226(GALNT6) 11227(GALNT5) 114805(GALNT13) 117248(GALNT15) 168391(GALNTL5) 2589(GALNT1) 2590(GALNT2) 2591(GALNT3) 26290(GALNT8) 374378(GALNT18) 442117(GALNTL6) 50614(GALNT9) 51809(GALNT7) 55568(GALNT10) 57452(GALNT16) 63917(GALNT11) 64409(WBSCR17) 79623(GALNT14) 79695(GALNT12) 8693(GALNT4)
PTR: 
451027(GALNTL4) 451767(GALNT8) 451904(GALNT6) 457808(GALNT2) 459130(GALNT14) 459667(GALNT13) 459702(GALNT3) 462207(GALNT10) 463458(WBSCR17) 463877(GALNT11) 463878(GALNTL5) 467488(GALNTL1) 468521(GALNT1) 470563(GALNT5) 470761(GALNTL2) 471350(GALNTL6) 473486 740702(GALNT7) 746171(GALNT4) 747531(GALNT12)
PPS: 
100968173(GALNTL1) 100970082(GALNT5) 100970451(GALNT12) 100972708(GALNT13) 100974256(GALNT4) 100977525(GALNT6) 100980923(GALNTL2) 100981343(GALNT7) 100982058(GALNT10) 100984050(GALNT14) 100985196(GALNT1) 100985908(GALNT8) 100988844(GALNT2) 100990308(GALNTL5) 100990428(GALNT3) 100990655(GALNT11) 100991628(GALNTL4) 100992452(GALNTL6) 100993574(GALNT9)
GGO: 
101127419(GALNT12) 101128220(GALNTL6) 101128576(GALNT7) 101128775(GALNT4) 101130520(WBSCR17) 101131599(GALNT11) 101133234(GALNTL2) 101135115(GALNTL4) 101136192(GALNT14) 101138153(GALNT2) 101140138(GALNT1) 101142202(GALNT8) 101144407(GALNT6) 101150785(GALNTL1) 101151140(GALNT5) 101151147
PON: 
100171466(GALNT7) 100171713(GALNT14) 100431189(GALNT2) 100439914(GALNT1) 100441221(GALNTL4) 100441225(GALNT6) 100442252(GALNT3) 100443972(GALNTL6) 100449758(GALNTL5) 100450118(GALNT11) 100451033(GALNT13) 100451579(GALNT10) 100455002(GALNT5) 100455942(GALNTL1) 100456742(GALNT12) 100460846(GALNTL2) 100461536(GALNT4)
MCC: 
100430612(GALNT4) 694784(GALNTL2) 695019(GALNT6) 695207(WBSCR17) 695898(GALNTL6) 696924(GALNT7) 697430(GALNT5) 701790(GALNTL4) 705068(GALNT14) 707605(GALNT3) 708930(GALNT1) 710382(GALNT9) 714287(GALNT10) 714371(GALNT2) 714574(GALNTL1) 715128(GALNT12) 715572(GALNT11) 716567 721912(GALNT8)
MMU: 
108148(Galnt2) 108150(Galnt7) 108760(Galnt16) 14423(Galnt1) 14425(Galnt3) 14426(Galnt4) 171212(Galnt10) 207839(Galnt6) 212996(Wbscr17) 230145(Galnt12) 231050(Galnt11) 233733(Galnt18) 241391(Galnt5) 270049(Galntl6) 271786(Galnt13) 67909(Galntl5) 71685(Galnt14) 78754(Galnt15)
RNO: 
100360475(Galnt15) 100361647(Galnt6) 170501(Galnt10) 288611(Wbscr17) 292090(Galnt2) 293181(Galnt18) 29750(Galnt7) 311039(Galnt13) 311952(Galnt11) 313233(Galnt12) 313878(Galnt14) 361142(Galntl6) 362760(Galnt16) 366061(Galnt3) 499968(Galntl5) 500826(Galnt4) 79214(Galnt1) 83627(Galnt5)
CFA: 
100682763(GALNT2) 474777(GALNT12) 477056(GALNTL2) 478753(GALNT13) 478774(GALNT3) 480161(GALNT1) 480370(GALNTL1) 482809(GALNT11) 483025(GALNT14) 485390(GALNTL4) 486063(GALNTL6) 486224(GALNT9) 486734(GALNT8) 486771(GALNT7) 488359(GALNT5) 489165(GALNT10) 489790(WBSCR17) 607787(GALNT6) 611040(GALNTL5)
AML: 
FCA: 
101081320(GALNT3) 101083227(WBSCR17) 101083669(GALNT11) 101086384(GALNTL5) 101089099(GALNTL6) 101089934(GALNT14) 101090138(GALNTL4) 101090539(GALNT5) 101091362(GALNT7) 101093556(GALNT12) 101094456(GALNT1) 101094703(GALNT2) 101096076(GALNT6) 101096836(GALNTL2) 101097132(GALNT10) 101097673(GALNT9) 101097905(GALNT4) 101099809(GALNTL1)
BTA: 
100125265(GALNT4) 282241(GALNT1) 504711(GALNT5) 504951(GALNT9) 505622(WBSCR17) 506903(GALNT6) 508488(GALNT12) 524529(GALNT7) 526331(GALNTL1) 532545(GALNT13) 534904(GALNT11) 535458(GALNT3) 540500(GALNT14) 540652(GALNT8) 614203(GALNTL4) 615819(GALNTL6) 616218(GALNT2) 617031(GALNTL5) 618078(GALNTL2) 787200(GALNT10)
SSC: 
100153028(GALNT2) 100156842(GALNT9) 100157572(GALNTL2) 100158205(GALNT7) 100511419(GALNT10) 100512452(GALNT12) 100513992(GALNTL1) 100514952 100515515(GALNT11) 100515629(GALNT3) 100515695 100519410(GALNTL4) 100522491(GALNT8) 100621801 100627600(GALNT5) 100738063 100738545 100738635(GALNT4)
ECB: 
100050588(GALNT13) 100050823(GALNT5) 100051940(GALNT3) 100052358(GALNTL2) 100052833 100058625 100060897(GALNT6) 100060956 100061194(GALNTL6) 100063207(GALNT4) 100063633(GALNT11) 100063861(GALNT12) 100063926 100064586 100065695(GALNT2) 100066545 100070711(GALNT14) 100071405(GALNT10) 100071409
MDO: 
100010613 100010982(GALNT1) 100011789 100013701 100015873(GALNT11) 100019338 100019347(GALNT8) 100019519(GALNTL6) 100020598(GALNT13) 100021225(GALNT5) 100022258(GALNT2) 100023186 100028262(GALNT9) 100028689 100029985(GALNTL4) 100030660 100031452(GALNT14)
SHR: 
100913537 100914362(GALNT12) 100917578(GALNT3) 100920318(GALNT11) 100921891(GALNTL4) 100925221(GALNT10) 100925740(GALNTL1) 100928169(GALNT1) 100930509(GALNT5) 100932016(GALNT2) 100932845(GALNT9) 100933497 100934394(GALNT14) 100934808(GALNT7)
OAA: 
100074266 100075634 100076970(GALNT10) 100077198 100077335(GALNT3) 100079372(GALNT14) 100080309 100080971(GALNT13) 100081487(GALNT5) 100082272(GALNT1) 100082436(GALNT11) 100084102(GALNTL2) 100092328(GALNT12) 100092956
GGA: 
416260(GALNT10) 416796(GALNT9) 417480(WBSCR17) 420436(GALNT11) 420642(GALNTL2) 420955(GALNT1) 420978(GALNT12) 421305(GALNT14) 421540(GALNT2) 422560(GALNTL6) 422561(GALNT7) 423034(GALNTL4) 423263(GALNTL1) 424177(GALNT3) 424319(GALNT13) 424324(GALNT5) 429501(GALNT6)
MGP: 
100539607 100542228(GALNTL2) 100542413(GALNT4) 100543050(GALNTL4) 100544386(GALNT1) 100544871(GALNT13) 100545172 100545954 100547543 100547876 100548094 100548952 100550869
TGU: 
100218474(GALNT10) 100219937(GALNT9) 100220675(GALNT15) 100221225(GALNT2) 100222501(GALNT12) 100223249(GALNT7) 100225198(WBSCR17) 100225482(GALNT18) 100225764(GALNT16) 100226111(GALNTL6) 100227566(GALNT3) 100228681(GALNT5) 100229109(GALNT1) 100229575(GALNT14) 100231024(GALNT11)
ACS: 
100552674 100553001(galntl6) 100553448(galnt1) 100553625(galnt14) 100553777(galnt11) 100553930 100554029 100556410 100556784(galntl2) 100557458(galnt3) 100559679(galnt13) 100561039 100561683(galnt6) 100563296(galnt9) 100564266(galntl4) 100566755(galnt10) 100567307(galnt2)
XLA: 
100101309(galnt16) 100158361 100381149(galnt6) 398911(galnt1) 431894(galnt7) 432105(galnt4) 444557(galnt13) 447314(galnt11)
XTR: 
100485011 100487935(galntl6) 100488284 100488466(galnt3) 100489899 100490061(galnt9) 100497888 100497898 407859(galnt7) 448751(galnt11) 550031(galnt13) 594943(galnt1) 733908(galnt16) 779822(galnt14) 779898(galnt10) 780162(galnt4)
DRE: 
100170813(galnt18a) 100310831(galnt18b) 100330695(galnt13) 100535692(galnt8) 406477(fc23d02) 503760(poc1bl) 553668(galnt7) 558716(galnt11) 559073(galnt1) 559373(galnt8b) 559736(galnt12) 562739(galnt14) 567794 568547(galnt8a) 570248(galnt2) 797549(galnt9) 799387(galntl1)
TRU: 
101061084 101062548 101067037 101067378 101068080 101069400 101070064 101072353 101072395 101075088 101075239 101075435 101076724 101076971 101077798 101078998 101079274 101079501 101079939
OLA: 
101155477 101158340 101160340 101161071 101161358 101161598 101162458 101162693 101164556 101166578 101166838 101167608 101170356 101170818 101171188 101172857 101172873 101173021
BFO: 
BRAFLDRAFT_105269 BRAFLDRAFT_114107 BRAFLDRAFT_114654 BRAFLDRAFT_125191 BRAFLDRAFT_127524 BRAFLDRAFT_208719 BRAFLDRAFT_246892 BRAFLDRAFT_248153
CIN: 
100175975 100176918(galnt4) 100179270(galnt2) 100181305(galnt1)
SPU: 
574835 575483 575722 579469 586004
DME: 
Dmel_CG10000 Dmel_CG2103(pgant6) Dmel_CG30463 Dmel_CG31651(pgant5) Dmel_CG31776 Dmel_CG31956(pgant4) Dmel_CG3254(pgant2) Dmel_CG4445(pgant3) Dmel_CG6394(GalNAc-T2) Dmel_CG7297(pgant8) Dmel_CG7304 Dmel_CG7480(Pgant35A) Dmel_CG7579 Dmel_CG8182(GalNAc-T1)
DPO: 
Dpse_GA15243 Dpse_GA16368 Dpse_GA16586 Dpse_GA16973 Dpse_GA18187 Dpse_GA19561 Dpse_GA20382 Dpse_GA20875 Dpse_GA25136
DAN: 
Dana_GF12252 Dana_GF13042 Dana_GF13455 Dana_GF14884 Dana_GF15237 Dana_GF15238 Dana_GF15680 Dana_GF15722 Dana_GF16431 Dana_GF22410 Dana_GF24092 Dana_GF24250
DER: 
Dere_GG10775 Dere_GG12057 Dere_GG13525 Dere_GG14889 Dere_GG15923 Dere_GG15924 Dere_GG18114 Dere_GG20529 Dere_GG22251 Dere_GG24317 Dere_GG24441 Dere_GG24946 Dere_GG24947 Dere_GG25115
DPE: 
Dper_GL10955 Dper_GL11821 Dper_GL18655 Dper_GL18803 Dper_GL19517 Dper_GL20074 Dper_GL21271 Dper_GL22638 Dper_GL27027
DSE: 
Dsec_GM11141 Dsec_GM11142 Dsec_GM12286 Dsec_GM14515 Dsec_GM15572 Dsec_GM18035 Dsec_GM18147 Dsec_GM20039 Dsec_GM20824 Dsec_GM21620 Dsec_GM22807 Dsec_GM24469 Dsec_GM25553 Dsec_GM25555
DSI: 
Dsim_GD10277 Dsim_GD11122 Dsim_GD11982 Dsim_GD12542 Dsim_GD13712 Dsim_GD14568 Dsim_GD14569 Dsim_GD15630 Dsim_GD18021 Dsim_GD22759 Dsim_GD23235 Dsim_GD23236 Dsim_GD23962 Dsim_GD25523
DWI: 
Dwil_GK10725 Dwil_GK10985 Dwil_GK14594 Dwil_GK15558 Dwil_GK16570 Dwil_GK18112 Dwil_GK18434 Dwil_GK21532 Dwil_GK23025 Dwil_GK23729 Dwil_GK25256
DYA: 
Dyak_GE10498 Dyak_GE11714 Dyak_GE14045 Dyak_GE14879 Dyak_GE15519 Dyak_GE18237 Dyak_GE18238 Dyak_GE18697 Dyak_GE19032 Dyak_GE20340 Dyak_GE22270 Dyak_GE22271 Dyak_GE22825 Dyak_GE24246
DGR: 
Dgri_GH10909 Dgri_GH11183 Dgri_GH11345 Dgri_GH11491 Dgri_GH12336 Dgri_GH14160 Dgri_GH16989 Dgri_GH17086 Dgri_GH20244 Dgri_GH20386 Dgri_GH22705
DMO: 
Dmoj_GI10532 Dmoj_GI11401 Dmoj_GI11687 Dmoj_GI12891 Dmoj_GI13183 Dmoj_GI15842 Dmoj_GI16986 Dmoj_GI18492 Dmoj_GI19414 Dmoj_GI20058
DVI: 
Dvir_GJ10330 Dvir_GJ11361 Dvir_GJ11465 Dvir_GJ11806 Dvir_GJ13596 Dvir_GJ14949 Dvir_GJ15190 Dvir_GJ18184 Dvir_GJ21354 Dvir_GJ22477 Dvir_GJ24116 Dvir_GJ24184
AGA: 
AgaP_AGAP000656 AgaP_AGAP004429 AgaP_AGAP006881 AgaP_AGAP006925 AgaP_AGAP008229 AgaP_AGAP008613 AgaP_AGAP010078 AgaP_AGAP012414
AAG: 
AaeL_AAEL000654 AaeL_AAEL001121 AaeL_AAEL004538 AaeL_AAEL006452 AaeL_AAEL008037 AaeL_AAEL008252 AaeL_AAEL011095 AaeL_AAEL012823 AaeL_AAEL013274
CQU: 
CpipJ_CPIJ005695 CpipJ_CPIJ005697 CpipJ_CPIJ007696 CpipJ_CPIJ009181 CpipJ_CPIJ009408 CpipJ_CPIJ011238 CpipJ_CPIJ013569 CpipJ_CPIJ014647 CpipJ_CPIJ017883
AME: 
100578215 410470 410938(pgant3) 411054 411799(GalNAc-T2) 413987 552496
NVI: 
100117315(NV17598) 100117924(NV15903) 100118765(NV10039) 100118787(NV11868) 100120912(NV50068) 100121727(NV13453)
TCA: 
658118 658959 661929(PNR-like) 662349 662767 663798 664097
API: 
100159657 100162214 100162325 100164321 100166413 100166487 100167831
PHU: 
Phum_PHUM055320 Phum_PHUM170220 Phum_PHUM268270 Phum_PHUM401800 Phum_PHUM496390 Phum_PHUM498070 Phum_PHUM590070
ISC: 
IscW_ISCW001971 IscW_ISCW006788 IscW_ISCW008344 IscW_ISCW008544 IscW_ISCW008981 IscW_ISCW012212 IscW_ISCW017814
CEL: 
CELE_Y116F11B.12(gly-4) CELE_Y39E4B.12(gly-5) CELE_Y45F10D.3(gly-10) CELE_Y46H3A.6(gly-7) CELE_ZK688.8(gly-3)
CBR: 
CBG12289(Cbr-gly-3) CBG13209(Cbr-gly-9) CBG21807(Cbr-gly-7) CBG22373(Cbr-gly-10) CBG23000(Cbr-gly-5) CBG23019(Cbr-gly-11) CBG24518(Cbr-gly-4)
BMY: 
Bm1_02810 Bm1_23955 Bm1_34610 Bm1_39295 Bm1_45025 Bm1_46045 Bm1_47265 Bm1_51265
TSP: 
Tsp_00063 Tsp_00506 Tsp_02203 Tsp_10803
SMM: 
Smp_005500 Smp_057620 Smp_139230
NVE: 
NEMVE_v1g138673 NEMVE_v1g141560 NEMVE_v1g192133 NEMVE_v1g31464 NEMVE_v1g91041
HMG: 
100197345 100209581 100213223 100215859
TAD: 
TRIADDRAFT_22201 TRIADDRAFT_22565 TRIADDRAFT_22839 TRIADDRAFT_22976 TRIADDRAFT_27318
AQU: 
100640418
MBR: 
MONBRDRAFT_23972 MONBRDRAFT_24325 MONBRDRAFT_27397 MONBRDRAFT_29734 MONBRDRAFT_32151 MONBRDRAFT_37866 MONBRDRAFT_38577
CPV: 
cgd7_4160
TGO: 
TGME49_056080 TGME49_059530 TGME49_118730
TPS: 
THAPSDRAFT_32016
 » show all
Taxonomy
Reference
1  [PMID:6809738]
  Authors
Sugiura M, Kawasaki T, Yamashina I.
  Title
Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66.
  Journal
J. Biol. Chem. 257 (1982) 9501-7.
  Organism
Bos taurus [GN:bta]
Reference
2
  Authors
Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H.
  Title
Purification and characterization of UDP-N-acetylgalactosamine-kappa-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow.
  Journal
Agric. Biol. Chem. 49 (1985) 1059-1069.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-15-4
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