| Entry |
|
|---|
| Name |
polypeptide N-acetylgalactosaminyltransferase;
protein-UDP acetylgalactosaminyltransferase;
UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase;
UDP-N-acetylgalactosamine:kappa-casein polypeptide
N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-glycoprotein
acetylgalactosaminyltransferase;
glycoprotein acetylgalactosaminyltransferase;
polypeptide-N-acetylgalactosamine transferase;
UDP-acetylgalactosamine-glycoprotein
acetylgalactosaminyltransferase;
UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase;
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase;
UDP-N-acetyl-alpha-D-galactosamine:polypeptide
N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine-glycoprotein
N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:polypeptide
N-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl
transferase;
ppGalNAc-T |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-galactosamine:polypeptide
N-acetylgalactosaminyl-transferase |
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| Reaction(IUBMB) |
UDP-N-acetyl-D-galactosamine + polypeptide = UDP +
N-acetyl-D-galactosaminyl-polypeptide [RN:R02183] |
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| Reaction(KEGG) |
R02183 > R05907(G)
 |
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| Substrate |
UDP-N-acetyl-D-galactosamine [CPD:C00203];
polypeptide [CPD:C00403] |
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| Product |
UDP [CPD:C00015];
N-acetyl-D-galactosaminyl-polypeptide [CPD:C04387] |
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| Cofactor |
Manganese [CPD:C00034];
Calcium [CPD:C00076] |
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| Comment |
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to
threonine or serine hydroxy groups on the polypeptide core of
submaxillary mucin, kappa-casein, apofetuin and some other acceptors
of high molecular mass. |
|---|
| Pathway |
PATH: ec00512 O-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00710 polypeptide N-acetylgalactosaminyltransferase
KO: K09667 polypeptide N-acetylglucosaminyltransferase |
|---|
| Genes |
HSA: 11226(GALNT6) 11227(GALNT5) 114805(GALNT13) 117248(GALNTL2)
168391(GALNTL5) 2589(GALNT1) 2590(GALNT2) 2591(GALNT3)
26290(GALNT8) 374378(GALNTL4) 442117(GALNTL6) 50614(GALNT9)
51809(GALNT7) 55568(GALNT10) 57452(GALNTL1) 63917(GALNT11)
64409(WBSCR17) 79623(GALNT14) 79695(GALNT12) 8473(OGT)
8693(GALNT4)
PTR: 451027(GALNTL4) 451904(GALNT6) 457808(GALNT2) 459130(GALNT14)
459667(GALNT13) 459702(GALNT3) 462207(GALNT10) 463458(WBSCR17)
463877(GALNT11) 465702(OGT) 467488(GALNTL1) 468521(GALNT1)
470563(GALNT5) 470761(GALNTL2) 471350(GALNTL6) 747531(GALNT12)
MCC: 694784(GALNTL2) 695019(GALNT6) 695207(WBSCR17) 695898(GALNTL6)
696924(GALNT7) 697430(GALNT5) 701790(GALNTL4) 705068(GALNT14)
707605(GALNT3) 708930 710382(GALNT9) 714287 714371
714574(GALNTL1) 715128 715572(GALNT11) 716567 721912(GALNT8)
MMU: 108148(Galnt2) 108150(Galnt7) 108155(Ogt) 108760(Galntl1)
14423(Galnt1) 14425(Galnt3) 14426(Galnt4) 171212(Galnt10)
207839(Galnt6) 212996(Wbscr17) 230145(Galnt12) 231050(Galnt11)
233733(Galntl4) 241391(Galnt5) 271786(Galnt13) 67909(Galntl5)
71685(Galnt14) 78754(Galntl2)
RNO: 170501(Galnt10) 26295(Ogt) 288611(Wbscr17) 292090(Galnt2)
293181(Galntl4) 29750(Galnt7) 306268(Galntl2) 311039(Galnt13)
311952(Galnt11) 313233(Galnt12) 313878(Galnt14) 361142(Galntl6)
362760(Galntl1) 366061(Galnt3) 499968(Galntl5) 500826(Galnt4)
683264 79214(Galnt1) 83627(Galnt5)
CFA: 474777(GALNT12) 477056(GALNTL2) 478753(GALNT13) 478774(GALNT3)
480161(GALNT1) 480370(GALNTL1) 480955(OGT) 482809(GALNT11)
483025(GALNT14) 485390(GALNTL4) 486224(GALNT9) 486734(GALNT8)
486771(GALNT7) 488359 489165(GALNT10) 489790 607787(GALNT6)
611040(GALNTL5)
BTA: 100125265(GALNT4) 282241(GALNT1) 504711(GALNT5) 505622
506903(GALNT6) 508488(GALNT12) 524529(GALNT7) 526331(GALNTL1)
532053(OGT) 532545(GALNT13) 534904(GALNT11) 535458(GALNT3)
540500(GALNT14) 540652(GALNT8) 614203(GALNTL4) 615819(GALNTL6)
616218(GALNT2) 617031(GALNTL5) 618078(GALNTL2) 787200(GALNT10)
SSC: 100152872 100153028 100156842 100157457 100157572 100158205
664652(OGT)
ECB: 100050588 100050823(GALNT5) 100051940(GALNT3) 100052358
100052833 100056148(OGT) 100058625 100060897 100060956
100061194 100063207(GALNT4) 100063633(GALNT11)
100063861(GALNT12) 100063926 100064586 100065695(GALNT2)
100066545 100070711 100071405(GALNT10) 100071409
MDO: 100010613 100010982 100011073 100011789 100013701 100015873
100019338 100019347 100020598 100022258 100028262 100028689
100029985 100030660 100031452
OAA: 100074266 100075634 100076970 100077198 100077335 100079372
100080971 100081487 100082272 100082436 100084102 100092328
GGA: 416260(GALNT10) 416796(GALNT9) 417480(WBSCR17) 420436(GALNT11)
420642(GALNTL2) 420955(GALNT1) 420978(GALNT12) 421305(GALNT14)
421540(GALNT2) 422203(OGT) 422560(GALNTL6) 422561(GALNT7)
423034(GALNTL4) 423263(GALNTL1) 424177(GALNT3) 424319(GALNT13)
424324(GALNT5) 429501(GALNT6)
TGU: 100218474 100220675 100221225 100224237 100225198 100225482
100225764 100226111 100227566 100227632 100228681 100229109
100229575 100231024
XLA: 100101309 398911 431894 432105 444557 447314 447694(ogt)
XTR: 407859(galnt7) 448751(galnt11) 550031(galnt13) 553157(ogt)
594943(galnt1) 733908(galntl1) 779822(galnt14)
779898(MGC147591) 780162(galnt4)
DRE: 100150660 337685(ogt) 406477 503760(wdr51bl) 553668(galnt7)
558716(galnt11) 559073 559373 559736 561084 562739(galnt14)
567794 568915(CH211-15E22.3) 570248 652952(ogt.2)
797549(CH211-126H20.1) 798489
BFO: BRAFLDRAFT_114107 BRAFLDRAFT_114654 BRAFLDRAFT_117202
BRAFLDRAFT_127524 BRAFLDRAFT_208719 BRAFLDRAFT_246892
BRAFLDRAFT_248153
CIN: 100175975 100176918 100179270 100181206 100181305
SPU: 574835 575722 579289 579469
DME: Dmel_CG10000 Dmel_CG10392(Ogt) Dmel_CG2103(pgant6) Dmel_CG30463
Dmel_CG31651(pgant5) Dmel_CG31776 Dmel_CG31956(pgant4)
Dmel_CG3254(pgant2) Dmel_CG4445(pgant3) Dmel_CG6394(GalNAc-T2)
Dmel_CG7297(pgant8) Dmel_CG7304 Dmel_CG7480(Pgant35A)
Dmel_CG7579 Dmel_CG8182(GalNAc-T1)
DPO: Dpse_GA15243 Dpse_GA16368 Dpse_GA16973 Dpse_GA18187
Dpse_GA19561 Dpse_GA20382 Dpse_GA20875 Dpse_GA29107
DAN: Dana_GF12252 Dana_GF13042 Dana_GF13455 Dana_GF13981
Dana_GF14884 Dana_GF15237 Dana_GF15238 Dana_GF15680
Dana_GF15722 Dana_GF16431 Dana_GF22410 Dana_GF24092
Dana_GF24250
DER: Dere_GG10775 Dere_GG12057 Dere_GG13525 Dere_GG14889
Dere_GG15923 Dere_GG15924 Dere_GG18114 Dere_GG20529
Dere_GG22251 Dere_GG24317 Dere_GG24441 Dere_GG24946
Dere_GG24947 Dere_GG25115
DPE: Dper_GL10955 Dper_GL11821 Dper_GL13214 Dper_GL18655
Dper_GL18803 Dper_GL19517 Dper_GL20074 Dper_GL21271
Dper_GL22638 Dper_GL27027
DSE: Dsec_GM11101 Dsec_GM11141 Dsec_GM11142 Dsec_GM12286
Dsec_GM14515 Dsec_GM15572 Dsec_GM18035 Dsec_GM18147
Dsec_GM20039 Dsec_GM20824 Dsec_GM21620 Dsec_GM22807
Dsec_GM24469 Dsec_GM25553 Dsec_GM25555
DSI: Dsim_GD10277 Dsim_GD11122 Dsim_GD11982 Dsim_GD12542
Dsim_GD13712 Dsim_GD14568 Dsim_GD14569 Dsim_GD15630
Dsim_GD18021 Dsim_GD22759 Dsim_GD23235 Dsim_GD23236
Dsim_GD23962 Dsim_GD25523
DYA: Dyak_GE10498 Dyak_GE11714 Dyak_GE14045 Dyak_GE14879
Dyak_GE15519 Dyak_GE18237 Dyak_GE18238 Dyak_GE18697
Dyak_GE19032 Dyak_GE20340 Dyak_GE22270 Dyak_GE22271
Dyak_GE22825 Dyak_GE24246
DGR: Dgri_GH10909 Dgri_GH11183 Dgri_GH11345 Dgri_GH11491
Dgri_GH12336 Dgri_GH14160 Dgri_GH16989 Dgri_GH17086
Dgri_GH20244 Dgri_GH20386 Dgri_GH21711 Dgri_GH22705
DMO: Dmoj_GI10532 Dmoj_GI11401 Dmoj_GI11687 Dmoj_GI12891
Dmoj_GI13183 Dmoj_GI15842 Dmoj_GI16986 Dmoj_GI18492
Dmoj_GI18858 Dmoj_GI19414 Dmoj_GI20058
AGA: AgaP_AGAP000656 AgaP_AGAP004429 AgaP_AGAP006254 AgaP_AGAP006925
AgaP_AGAP008229 AgaP_AGAP008613 AgaP_AGAP010078 AgaP_AGAP012414
AAG: AaeL_AAEL000654 AaeL_AAEL001121 AaeL_AAEL004538 AaeL_AAEL006452
AaeL_AAEL008037 AaeL_AAEL011095 AaeL_AAEL012823 AaeL_AAEL013274
AaeL_AAEL014746
CQU: CpipJ_CPIJ004574 CpipJ_CPIJ005697 CpipJ_CPIJ007696
CpipJ_CPIJ009181 CpipJ_CPIJ009408 CpipJ_CPIJ011238
CpipJ_CPIJ013569 CpipJ_CPIJ014647 CpipJ_CPIJ017883
AME: 410470 411054 411799 413987 551425 552496
NVI: 100116809(Ogt) 100117315 100117924 100118765 100118787
100121727
TCA: 655930 658118 658959 661929 662349 662767 663798 664097
API: 100159657 100162214 100164321 100165765 100166413 100166487
100167831
ISC: IscW_ISCW006788 IscW_ISCW008344 IscW_ISCW008544 IscW_ISCW008981
IscW_ISCW012212 IscW_ISCW017814
CEL: K04G7.3(ogt-1) Y116F11B.12(gly-4) Y39E4B.12(gly-5)
Y45F10D.3(gly-10) Y46H3A.6(gly-7) ZK688.8(gly-3)
CBR: CBG12289 CBG13209 CBG16605 CBG21807 CBG23000 CBG23019
BMY: Bm1_01735 Bm1_02810 Bm1_23955 Bm1_34610 Bm1_39295 Bm1_45025
Bm1_46045 Bm1_47265 Bm1_51265
SMM: Smp_005500 Smp_046930 Smp_057620 Smp_139230
NVE: NEMVE_v1g138673 NEMVE_v1g141560 NEMVE_v1g192133 NEMVE_v1g239520
NEMVE_v1g31464 NEMVE_v1g91041
HMG: 100197345 100201589 100206619 100209581 100213223 100215859
TAD: TRIADDRAFT_22201 TRIADDRAFT_22839 TRIADDRAFT_22976
TRIADDRAFT_27318 TRIADDRAFT_56833
ATH: AT3G04240(SEC)
POP: POPTR_895082
RCU: RCOM_0611050
VVI: 100244912
OSA: 4324353(Os01g0915400)
SBI: SORBI_04g019560(SORBIDRAFT_04g019560)
PPP: PHYPADRAFT_196321
MBR: MONBRDRAFT_27585
TGO: TGME49_118730
GLA: GL50803_12081
PTI: PHATR_44040
TPS: THAPSDRAFT_264240
 |
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| Structures |
PDB: 1XHB 2D7I 2D7R 2FFU 2FFV |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:6809738]
Sugiura M, Kawasaki T, Yamashina I.
Purification and characterization of UDP-GalNAc:polypeptide
N-acetylgalactosamine transferase from an ascites hepatoma, AH 66.
J. Biol. Chem. 257 (1982) 9501-7.
Bos taurus [GN:bta] |
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Reference
Authors
Title
Journal
|
2
Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H.
Purification and characterization of
UDP-N-acetylgalactosamine-kappa-casein polypeptide
N-acetylgalactosaminyltransferase from mammary-gland of lactating
cow.
Agric. Biol. Chem. 49 (1985) 1059-1069. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.41
IUBMB Enzyme Nomenclature: 2.4.1.41
ExPASy - ENZYME nomenclature database: 2.4.1.41
BRENDA, the Enzyme Database: 2.4.1.41
CAS: 9075-15-4 |
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