KEGG   ENZYME: 2.4.1.46Help
Entry
EC 2.4.1.46                 Enzyme                                 

Name
monogalactosyldiacylglycerol synthase;
uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose:diacylglycerol galactosyltransferase;
MGDG synthase;
UDP galactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose-diacylglyceride galactosyltransferase;
UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase;
1beta-MGDG;
1,2-diacylglycerol 3-beta-galactosyltransferase;
UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol [RN:R02691]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
UDP [CPD:C00015];
1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
Comment
This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].
History
EC 2.4.1.46 created 1972, modified 2003, modified 2005
Pathway
Glycerolipid metabolism
Metabolic pathways
Orthology
K03715  
1,2-diacylglycerol 3-beta-galactosyltransferase
Genes
ATH: 
AT2G11810(MGDC) AT4G31780(MGD1) AT5G20410(MGD2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0802700-01(Os02g0802700) Os08t0299400-01(Os08g0299400) Os09t0423600-01(Os09g0423600)
BDI: 
SBI: 
SORBI_02g025070(SORBIDRAFT_02g025070) SORBI_04g036240(SORBIDRAFT_04g036240) SORBI_07g027910(SORBIDRAFT_07g027910)
ZMA: 
SITA: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
MIS: 
MPP: 
CSL: 
CME: 
GSL: 
CCP: 
PTI: 
TPS: 
NGD: 
EHX: 
GTT: 
AJS: 
CTH: 
TBE: 
SUS: 
PLP: 
CAP: 
 » show all
Taxonomy
Reference
1  [PMID:4838219]
  Authors
Veerkamp JH.
  Title
Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.
  Journal
Biochim. Biophys. Acta. 348 (1974) 23-34.
  Organism
Bifidobacterium bifidum
Reference
2  [PMID:5681471]
  Authors
Wenger DA, Petitpas JW, Pieringer RA.
  Title
The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.
  Journal
Biochemistry. 7 (1968) 3700-7.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:10518794]
  Authors
Miege C, Marechal E, Shimojima M, Awai K, Block MA, Ohta H, Takamiya K, Douce R, Joyard J.
  Title
Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG.
  Journal
Eur. J. Biochem. 265 (1999) 990-1001.
  Organism
Spinacia oleracea
  Sequence
[up:Q9SM44]
Reference
4  [PMID:15590685]
  Authors
Benning C, Ohta H.
  Title
Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants.
  Journal
J. Biol. Chem. 280 (2005) 2397-400.
  Organism
Arabidopsis sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37277-55-7

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