| Entry |
|
|---|
| Name |
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl)
galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
galactosyl-D-glucosyl-N-acylsphingosine
beta-1,3-D-galactosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac
tosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine
3-beta-D-galactosyltransferase |
|---|
| Reaction(IUBMB) |
UDP-galactose +
N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-
beta-D-glucosyl-N-acylsphingosine = UDP +
D-galactosyl-(1->3)-beta-N-acetyl-D-galactosaminyl-(N-
acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
[RN:R04631 R05941] |
|---|
| Reaction(KEGG) |
R04631 R05941(G);
(other) R05110 R05111 R05948(G) R05953(G) R05956(G)
 |
|---|
| Substrate |
UDP-galactose [CPD:C00052];
N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-
beta-D-glucosyl-N-acylsphingosine |
|---|
| Product |
UDP [CPD:C00015];
D-galactosyl-(1->3)-beta-N-acetyl-D-galactosaminyl-(N-
acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine |
|---|
| Comment |
The substrate is also known as GM2. |
|---|
| Pathway |
PATH: ec00604 Glycosphingolipid biosynthesis - ganglio series
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00715 ganglioside galactosyltransferase |
|---|
| Genes |
HSA: 8705(B3GALT4)
PTR: 746800(B3GALT4)
MCC: 718178(B3GALT4)
MMU: 100045158 54218(B3galt4)
RNO: 171079(B3galt4)
CFA: 481737(B3GALT4)
BTA: 768038(B3GALT4)
SSC: 100155431
ECB: 100052704
MDO: 100027150
DRE: 799047(DKEYP-87A12.9)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5842076]
Basu S, Kaufman B, Roseman S.
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain
uridine diphosphate D-galactose: glycolipid galactosyltransferase.
J. Biol. Chem. 240 (1965) 4115-7.
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc], Gallus gallus
[GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4987145]
Yip GB, Dain JA.
The enzymic synthesis of ganglioside. II. UDP-galactose:
N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceram
ide galactosyltransferase in rat brain.
Biochim. Biophys. Acta. 206 (1970) 252-60.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5484669]
Yip MC, Dain JA.
Frog brain uridine diphosphate
galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosy
lceram ide galactosyltransferase.
Biochem. J. 118 (1970) 247-52.
frog |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.62
IUBMB Enzyme Nomenclature: 2.4.1.62
ExPASy - ENZYME nomenclature database: 2.4.1.62
BRENDA, the Enzyme Database: 2.4.1.62
CAS: 37217-28-0 |
|---|
