3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase;
(Lea)-dependent (alpha-3/4)-fucosyltransferase;
alpha(1,3/1,4) fucosyltransferase III;
alpha-(1->4)-L-fucosyltransferase;
alpha-4-L-fucosyltransferase;
beta-acetylglucosaminylsaccharide fucosyltransferase;
FucT-II;
Lewis alpha-(1->3/4)-fucosyltransferase;
Lewis blood group alpha-(1->3/4)-fucosyltransferase;
Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase;
blood group Lewis alpha-4-fucosyltransferase;
blood-group substance Lea-dependent fucosyltransferase;
guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase;
guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase;
guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase;
3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase;
GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase;
GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase

Transferases;
Glycosyltransferases;
Hexosyltransferases

GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R [RN:R04553]

R04553 > R06155(G);
(other) R06162(G) R06163(G) R06164(G) R06165(G)

GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R

This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-alpha-fucosylation of the GlcNAc in beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.

1  [PMID:7287719]

Prieels JP, Monnom D, Dolmans M, Beyer TA, Hill RL.

Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk.

J. Biol. Chem. 256 (1981) 10456-63.

Homo sapiens [GN:hsa]

2  [PMID:10671538]

Rasko DA, Wang G, Palcic MM, Taylor DE.

Cloning and characterization of the alpha(1,3/4) fucosyltransferase of Helicobacter pylori.

J. Biol. Chem. 275 (2000) 4988-94.

Helicobacter pylori

3  [PMID:12084979]

Wilson IB.

Identification of a cDNA encoding a plant Lewis-type alpha1,4-fucosyltransferase.

Glycoconj. J. 18 (2001) 439-47.

Solanum lycopersicum

4  [PMID:12676935]

Ma B, Wang G, Palcic MM, Hazes B, Taylor DE.

C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer.

J. Biol. Chem. 278 (2003) 21893-900.

Helicobacter pylori