KEGG   ENZYME: 2.4.1.68Help
Entry
EC 2.4.1.68                 Enzyme                                 

Name
glycoprotein 6-alpha-L-fucosyltransferase;
GDP-fucose---glycoprotein fucosyltransferase;
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase;
GDP-L-fucose-glycoprotein fucosyltransferase;
glycoprotein fucosyltransferase;
guanosine diphosphofucose-glycoprotein fucosyltransferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase;
FucT;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase
Reaction(IUBMB)
GDP-beta-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine [RN:R05988]
Reaction(KEGG)
R05988(G) > R09319(G)
Show
Substrate
GDP-beta-L-fucose [CPD:C00325];
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine
Product
GDP [CPD:C00035];
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine
Comment
This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.
History
EC 2.4.1.68 created 1972, modified 2002
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Metabolic pathways
Orthology
K00717  
glycoprotein 6-alpha-L-fucosyltransferase
Genes
HSA: 
2530(FUT8)
PTR: 
449506(FUT8)
PPS: 
GGO: 
PON: 
100437943(FUT8)
MCC: 
708839(FUT8)
MCF: 
MMU: 
53618(Fut8)
RNO: 
432392(Fut8)
CGE: 
100751648(Fut8)
HGL: 
101697170(Fut8)
TUP: 
102482164(FUT8)
CFA: 
448804(FUT8)
AML: 
FCA: 
101089525(FUT8)
PTG: 
BTA: 
281177(FUT8)
BOM: 
102272152(FUT8)
PHD: 
102328772(FUT8)
CHX: 
102190043(FUT8)
OAS: 
101111372(FUT8)
SSC: 
396933(FUT8)
CFR: 
102517686(FUT8)
BACU: 
103000193(FUT8)
LVE: 
103072802(FUT8)
ECB: 
100052546(FUT8)
MYB: 
MYD: 
102774852(FUT8)
PALE: 
102882725(FUT8)
MDO: 
100022835(FUT8)
SHR: 
OAA: 
GGA: 
423178(FUT8)
MGP: 
100546497(FUT8)
APLA: 
101800631(FUT8)
TGU: 
100229671(FUT8)
FAB: 
101808667(FUT8)
PHI: 
102109111(FUT8)
FPG: 
FCH: 
102052916(FUT8)
CLV: 
102093557(FUT8)
ASN: 
102375447(FUT8)
AMJ: 
102562325(FUT8)
PSS: 
102448855(FUT8)
CMY: 
102936338(FUT8)
ACS: 
100553032(fut8)
PBI: 
103068068(FUT8)
XLA: 
394383(fut8-a) 779338(fut8-b)
XTR: 
407913(fut8)
DRE: 
797512(fut8a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348117(FUT8)
CMK: 
103175217(fut8)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
Dpse_GA15369(Dpse_FucT6)
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE17606(Dyak_FucT6)
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552522(FucT6)
NVI: 
100114017(FucT6)
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG09273(Cbr-fut-8)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
SMO: 
BPG: 
CSL: 
DPP: 
DFA: 
DFA_12228(fut8)
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:7083256]
  Authors
Longmore GD, Schachter H.
  Title
Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich fraction from porcine liver.
  Journal
Carbohydr. Res. 100 (1982) 365-92.
Reference
2  [PMID:3364733]
  Authors
Voynow JA, Scanlin TF, Glick MC.
  Title
A quantitative method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1----6fucosyltransferase activity with lectin affinity chromatography.
  Journal
Anal. Biochem. 168 (1988) 367-73.
Reference
3  [PMID:8910378]
  Authors
Uozumi N, Yanagidani S, Miyoshi E, Ihara Y, Sakuma T, Gao CX, Teshima T, Fujii S, Shiba T, Taniguchi N.
  Title
Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase.
  Journal
J. Biol. Chem. 271 (1996) 27810-7.
  Sequence
[ssc:396933]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-08-3

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