| Entry |
|
|---|
| Name |
galactoside 2-alpha-L-fucosyltransferase;
blood group H alpha-2-fucosyltransferase;
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase;
alpha-2-fucosyltransferase;
alpha-2-L-fucosyltransferase;
blood-group substance H-dependent fucosyltransferase;
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase;
guanosine diphosphofucose-lactose fucosyltransferase;
GDP fucose-lactose fucosyltransferase;
guanosine diphospho-L-fucose-lactose fucosyltransferase;
guanosine
diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase;
guanosine
diphosphofucose-
galactosylacetylglucosaminylgalactosylglucosylceramide
alpha-L-fucosyltransferase;
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase;
H-gene-encoded beta-galactoside alpha1->2fucosyltransferase;
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase;
GDP-L-fucose:lactose fucosyltransferase;
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosami
nyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide
2-alpha-L-fucosyltransferase |
|---|
| Reaction(IUBMB) |
GDP-beta-L-fucose +
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-
galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide = GDP +
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-
glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-
ceramide [RN:R04081] |
|---|
| Reaction(KEGG) |
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G)
R06086(G) R06089(G) R06090(G) R06156(G);
(other) R06170(G)
 |
|---|
| Substrate |
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-
galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide |
|---|
| Product |
GDP [CPD:C00035];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-
glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-
ceramide |
|---|
| Comment |
Free lactose can act as acceptor. Normally acts on a glycoconjugate
where R (see reaction) is a glycoprotein or glycolipid. The action
on glycolipid was previously listed as EC 2.4.1.89. |
|---|
| Pathway |
PATH: ec00601 Glycosphingolipid biosynthesis - lacto and neolacto
series
PATH: ec00603 Glycosphingolipid biosynthesis - globo series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00718 galactoside 2-L-fucosyltransferase |
|---|
| Genes |
HSA: 2523(FUT1) 2524(FUT2)
PTR: 468944(FUT2) 468947(FUT1)
MCC: 718252(FUT1)
MMU: 14343(Fut1) 14344(Fut2)
RNO: 58924(Fut2) 81919(Fut1)
CFA: 484396(FUT1) 484398(FUT2)
BTA: 281174(FUT1) 281175(FUT2)
SSC: 397138(FUT1) 397139(FUT2)
ECB: 100054308 100054499
MDO: 100009874 100009916
OAA: 100085980
XLA: 398668(fut1)
XTR: 447958(fut1)
DDI: DDB_0191458(pgtA)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:804484]
Basu S, Basu M, Chien JL.
Enzymatic synthesis of a blood group H-related glycosphingolipid by
an alpha-fucosyltransferase from bovine spleen.
J. Biol. Chem. 250 (1975) 2956-62.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7372640]
Beyer TA, Hill RL.
Enzymatic properties of the beta-galactoside alpha 1 leads to 2
fucosyltransferase from porcine submaxillary gland.
J. Biol. Chem. 255 (1980) 5373-9.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6246105]
Beyer TA, Sadler JE, Hill RL.
Purification to homogeneity of H blood group beta-galactoside alpha
1 leads to 2 fucosyltransferase from porcine submaxillary gland.
J. Biol. Chem. 255 (1980) 5364-72.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
|
4
Grollman, A.P.
GDP-L-fucose:lactose fucosyltransferase from mammary gland.
Methods Enzymol. 8 (1966) 351-353. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.69
IUBMB Enzyme Nomenclature: 2.4.1.69
ExPASy - ENZYME nomenclature database: 2.4.1.69
BRENDA, the Enzyme Database: 2.4.1.69
CAS: 56093-23-3 |
|---|
