KEGG   ENZYME: 2.4.1.69Help
Entry
EC 2.4.1.69                 Enzyme                                 
Name
galactoside 2-alpha-L-fucosyltransferase;
blood group H alpha-2-fucosyltransferase;
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase;
alpha-(1->2)-L-fucosyltransferase;
alpha-2-fucosyltransferase;
alpha-2-L-fucosyltransferase;
blood-group substance H-dependent fucosyltransferase;
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase;
guanosine diphosphofucose-lactose fucosyltransferase;
GDP fucose-lactose fucosyltransferase;
guanosine diphospho-L-fucose-lactose fucosyltransferase;
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase;
guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase;
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase;
H-gene-encoded beta-galactoside alpha1->2fucosyltransferase;
secretor-type beta-galactoside alpha1->2fucosyltransferase;
beta-galactoside alpha1->2fucosyltransferase;
GDP-L-fucose:lactose fucosyltransferase;
GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 2-alpha-L-fucosyltransferase
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04081]
Reaction(KEGG)
R04081 > R05968(G) R06024(G) R06031(G) R06035(G) R06041(G) R06085(G) R06086(G) R06089(G) R06090(G) R06156(G);
(other) R06170(G)
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Substrate
GDP-beta-L-fucose [CPD:C00325];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
GDP [CPD:C00035];
alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Free lactose can act as acceptor. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. The action on glycolipid was previously listed as EC 2.4.1.89.
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K00718  
galactoside 2-L-fucosyltransferase 1/2
K12245  
bifunctional glycosyltransferase PgtA
Genes
HSA: 
2523(FUT1) 2524(FUT2)
PTR: 
468944(FUT2) 468947(FUT1)
PPS: 
100990363(FUT1) 100991035(FUT2)
GGO: 
PON: 
100171991(FUT1) 100445051(FUT2)
MCC: 
718252(FUT1)
MMU: 
14343(Fut1) 14344(Fut2) 56546(Sec1)
RNO: 
308586(Sec1) 58924(Fut2) 81919(Fut1)
CFA: 
484396(FUT1) 484398(FUT2) 484399
AML: 
FCA: 
101080847(FUT1) 101085847(FUT2)
BTA: 
281174(FUT1) 281175(FUT2) 281483(SEC1)
SSC: 
100524201(FUT2A) 397138(FUT1) 397139(FUT2)
ECB: 
100054216 100054259 100054308 100054499
MDO: 
100009874 100009916 100010332 100018242
SHR: 
100931578(FUT1)
OAA: 
100085980 100681084
ACS: 
100561462
XLA: 
398668(fut1)
XTR: 
100493351 447958(fut1)
AME: 
726095
TCA: 
655912
PHU: 
Phum_PHUM354220
DDI: 
DDB_G0283761(pgtA)
 » show all
Taxonomy
Reference
1  [PMID:804484]
  Authors
Basu S, Basu M, Chien JL.
  Title
Enzymatic synthesis of a blood group H-related glycosphingolipid by an alpha-fucosyltransferase from bovine spleen.
  Journal
J. Biol. Chem. 250 (1975) 2956-62.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:7372640]
  Authors
Beyer TA, Hill RL.
  Title
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J. Biol. Chem. 255 (1980) 5373-9.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:6246105]
  Authors
Beyer TA, Sadler JE, Hill RL.
  Title
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
  Journal
J. Biol. Chem. 255 (1980) 5364-72.
  Organism
Sus scofa [GN:ssc]
Reference
4
  Authors
Grollman, A.P.
  Title
GDP-L-fucose:lactose fucosyltransferase from mammary gland.
  Journal
Methods Enzymol. 8 (1966) 351-353.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56093-23-3
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