KEGG   ENZYME: 2.4.1.79Help
Entry
EC 2.4.1.79                 Enzyme                                 

Name
globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase;
globoside synthetase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase;
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase;
globoside synthase;
gUDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase;
beta3GalNAc-T1;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05631 R05962]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.
History
EC 2.4.1.79 created 1976, modified 2006
Pathway
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K00719  
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Genes
HSA: 
8706(B3GALNT1)
PTR: 
460824(B3GALNT1)
PPS: 
100974302(B3GALNT1)
GGO: 
101128316(B3GALNT1)
PON: 
100174453(B3GALNT1)
NLE: 
100582204(B3GALNT1)
MCC: 
703939(B3GALNT1)
MCF: 
102122721(B3GALNT1)
CJC: 
100412790(B3GALNT1)
MMU: 
26879(B3galnt1)
RNO: 
310508(B3galnt1)
CGE: 
100756438(B3galnt1)
NGI: 
103738016(B3galnt1)
HGL: 
OCU: 
100352272(B3GALNT1)
TUP: 
102470507(B3GALNT1)
CFA: 
100683634(B3GALNT1)
AML: 
UMR: 
103677240(B3GALNT1)
FCA: 
101092536(B3GALNT1)
PTG: 
102967614(B3GALNT1)
BTA: 
767844(B3GALNT1)
BOM: 
102268013(B3GALNT1)
PHD: 
CHX: 
102172392(B3GALNT1)
OAS: 
101104544(B3GALNT1)
SSC: 
397634(B3GALNT1)
CFR: 
102520987(B3GALNT1)
BACU: 
103007706(B3GALNT1)
LVE: 
ECB: 
100062101(B3GALNT1)
MYB: 
102245995(B3GALNT1)
MYD: 
102751273(B3GALNT1)
PALE: 
102885235(B3GALNT1)
MDO: 
100015392(B3GALNT1)
SHR: 
100914641(B3GALNT1)
OAA: 
100077633(B3GALNT1)
GGA: 
425010(B3GALNT1)
MGP: 
APLA: 
TGU: 
100228838(B3GALNT1)
FAB: 
PHI: 
102106993(B3GALNT1)
FPG: 
101912356(B3GALNT1)
FCH: 
102056837(B3GALNT1)
CLV: 
102087526(B3GALNT1)
ASN: 
102381398(B3GALNT1)
AMJ: 
102574149(B3GALNT1)
PSS: 
102454980(B3GALNT1)
CMY: 
102942089(B3GALNT1)
ACS: 
100564179(b3galnt1)
LCM: 
 » show all
Taxonomy
Reference
1  [PMID:4632917]
  Authors
Chien JL, Williams T, Basu S.
  Title
Biosynthesis of a globoside-type glycosphingolipid by a  -N-acetylgalactosaminyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 248 (1973) 1778-85.
Reference
2  [PMID:4433547]
  Authors
Ishibashi T, Kijimoto S, Makita A.
  Title
Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney.
  Journal
Biochim. Biophys. Acta. 337 (1974) 92-106.
Reference
3  [PMID:6425294]
  Authors
Taniguchi N, Makita A.
  Title
Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.
  Journal
J. Biol. Chem. 259 (1984) 5637-42.
Reference
4  [PMID:10993897]
  Authors
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K.
  Title
Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.
  Journal
J. Biol. Chem. 275 (2000) 40498-503.
  Sequence
[hsa:8706]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-46-1

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