| Entry |
|
|---|
| Name |
globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase;
uridine
diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide
acetylgalactosaminyltransferase;
globoside synthetase;
UDP-N-acetylgalactosamine:globotriaosylceramide
beta-3-N-acetylgalactosaminyltransferase;
galactosylgalactosylglucosylceramide
beta-D-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:globotriaosylceramide
beta1,3-N-acetylgalactosaminyltransferase;
globoside synthase;
galactosylgalactosylglucosylceramide
beta-D-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-
glucosylceramide beta-N-acetyl-D-galactosaminyltransferase;
beta3GalNAc-T1;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-
galactosyl-(1->4)-beta-D-glucosylceramide
3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-
galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide
3III-beta-N-acetyl-D-galactosaminyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galact
osyl-(1->4)-beta-D-glucosyl-(11)-ceramide
III3-beta-N-acetyl-D-galactosaminyltransferase |
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-D-galactosamine +
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-
(11)-ceramide = UDP +
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide [RN:R05631
R05962] |
|---|
| Reaction(KEGG) |
R05631 R05962(G)
 |
|---|
| Substrate |
UDP-N-acetyl-D-galactosamine [CPD:C00203];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-
(11)-ceramide |
|---|
| Product |
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide |
|---|
| Comment |
Globoside is a neutral glycosphingolipid in human erythrocytes and
has blood-group-P-antigen activity [4]. The enzyme requires a
divalent cation for activity, with Mn2+ required for maximal
activity [3]. UDP-GalNAc is the only sugar donor that is used
efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low
enzyme activity [3]. Lactosylceramide, globoside and gangliosides
GM3 and GD3 are not substrates [4]. For explanation of the
superscripted '3' in the systematic name, see GL-5.3.4. |
|---|
| Pathway |
PATH: ec00603 Glycosphingolipid biosynthesis - globo series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00719 galactosylgalactosylglucosylceramide
beta-D-acetylgalactosaminyltransferase |
|---|
| Genes |
HSA: 8706(B3GALNT1)
PTR: 460824(B3GALNT1)
MCC: 704055
MMU: 26879(B3galnt1)
RNO: 310508(B3galnt1)
BTA: 767844(B3GALNT1)
SSC: 397634(B3GALNT1)
ECB: 100062101
MDO: 100015392
OAA: 100077633
GGA: 425010(B3GALNT1)
TGU: 100228838
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4632917]
Chien JL, Williams T, Basu S.
Biosynthesis of a globoside-type glycosphingolipid by a
-N-acetylgalactosaminyltransferase from embryonic chicken brain.
J. Biol. Chem. 248 (1973) 1778-85.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4433547]
Ishibashi T, Kijimoto S, Makita A.
Biosynthesis of globoside and Forssman hapten from
trihexosylceramide and properties of
beta-N-acetyl-galactosaminyltransferase of guinea pig kidney.
Biochim. Biophys. Acta. 337 (1974) 92-106.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6425294]
Taniguchi N, Makita A.
Purification and characterization of UDP-N-acetylgalactosamine:
globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a
synthase of human blood group P antigen, from canine spleen.
J. Biol. Chem. 259 (1984) 5637-42.
Canis familiaris [GN:cfa] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:10993897]
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K,
Urano T, Furukawa K.
Expression cloning of human globoside synthase cDNAs. Identification
of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide
beta 1,3-N-acetylgalactosaminyltransferase.
J. Biol. Chem. 275 (2000) 40498-503.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.79
IUBMB Enzyme Nomenclature: 2.4.1.79
ExPASy - ENZYME nomenclature database: 2.4.1.79
BRENDA, the Enzyme Database: 2.4.1.79
CAS: 62213-46-1 |
|---|
