KEGG   ENZYME: 2.4.1.86Help
Entry
EC 2.4.1.86                 Enzyme                                 

Name
glucosaminylgalactosylglucosylceramide beta-galactosyltransferase;
uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase;
GalT-4;
paragloboside synthase;
glucosaminylgalactosylglucosylceramide 4-beta-galactosyltransferase;
lactotriaosylceramide 4-beta-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase;
UDP-Gal:LcOse3Cer(beta 1-4)galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosaminyl-(1->3)-D-galactosyl-(1->4)-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04610 R06006]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.1.86 created 1976
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Reference
1  [PMID:4335001]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a tetraglycosylceramide by a galactosyltransferase from rabbit bone marrow.
  Journal
J. Biol. Chem. 247 (1972) 1489-95.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:291963]
  Authors
Basu M, Presper KA, Basu S, Hoffman LM, Brooks SE.
  Title
Differential activities of glycolipid glycosyltransferases in Tay-Sachs disease: studies in cultured cells from cerebrum.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4270-4.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-46-5

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