KEGG   ENZYME: 2.4.1.87Help
Entry
EC 2.4.1.87                 Enzyme                                 

Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R [CPD:C00694]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Orthology
K00743  
N-acetyllactosaminide 3-alpha-galactosyltransferase
Genes
PON: 
CJC: 
100390928(GGTA1)
MMU: 
14594(Ggta1)
RNO: 
246766(Ggta1p)
CGE: 
100754535(Ggta1)
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
491357(GGTA1)
AML: 
UMR: 
FCA: 
493877(GGTA1)
PTG: 
BTA: 
281780(GGTA1)
BOM: 
PHD: 
CHX: 
OAS: 
443282(GGTA2P)
SSC: 
396733(GGTA1)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
100089476(GLT6D1)
ACS: 
PBI: 
AAE: 
aq_516(mtfC)
AFU: 
 » show all
Taxonomy
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J. Biol. Chem. 248 (1973) 1700-6.
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J. Biol. Chem. 260 (1985) 12927-34.
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J. Biol. Chem. 256 (1981) 5387-93.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
128449-51-4

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