KEGG   ENZYME: 2.4.1.87Help
Entry
EC 2.4.1.87                 Enzyme                                 
Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R [CPD:C00694]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide;
a glycoconjugate)
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Orthology
K00743  
N-acetyllactosaminide 3-alpha-galactosyltransferase
Genes
PTR: 
PON: 
MMU: 
14594(Ggta1)
RNO: 
246766(Ggta1p)
CFA: 
491357(GGTA1)
AML: 
FCA: 
493877(GGTA1)
BTA: 
281780(GGTA1)
SSC: 
396733(GGTA1)
ECB: 
MDO: 
100016105 100033073
SHR: 
100933356
AAE: 
aq_516(mtfC)
AFU: 
AF1728
 » show all
Taxonomy
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J. Biol. Chem. 248 (1973) 1700-6.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J. Biol. Chem. 260 (1985) 12927-34.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J. Biol. Chem. 256 (1981) 5387-93.
  Organism
Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
128449-51-4
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