KEGG   ENZYME: 2.4.1.88Help
Entry
EC 2.4.1.88                 Enzyme                                 

Name
globoside alpha-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase;
Forssman synthase;
globoside acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04182 R05965]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.1.88 created 1976
Pathway
Glycosphingolipid biosynthesis - globo series
Metabolic pathways
Orthology
K00722  
globoside alpha-N-acetylgalactosaminyltransferase
Genes
HSA: 
26301(GBGT1)
PTR: 
464823(GBGT1)
PPS: 
100978291(GBGT1)
GGO: 
101145846(GBGT1)
PON: 
100453106(GBGT1)
MCF: 
102119767(GBGT1)
MMU: 
227671(Gbgt1)
CGE: 
100771256(Gbgt1)
HGL: 
101726516(Gbgt1)
TUP: 
102477690(GBGT1)
CFA: 
403833(GBGT1)
AML: 
FCA: 
101090810(GBGT1)
PTG: 
102954717(GBGT1)
BTA: 
BOM: 
102282202(GBGT1)
PHD: 
102317887(GBGT1)
CHX: 
102180325(GBGT1)
OAS: 
101112039(GBGT1)
CFR: 
BACU: 
LVE: 
103086807(GBGT1)
ECB: 
100069388(GBGT1)
MYB: 
MYD: 
PALE: 
102880609(GBGT1)
MDO: 
100017839(GBGT1)
SHR: 
100918940(GBGT1)
OAA: 
100090987(GBGT1)
GGA: 
417163(GBGT1)
MGP: 
TGU: 
100225394(GBGT1)
FAB: 
101806513(GBGT1)
PHI: 
102103511(GBGT1)
APLA: 
101799653(GBGT1)
FPG: 
101921547(GBGT1)
FCH: 
102050463(GBGT1)
CLV: 
102095912(GBGT1)
ASN: 
102388459(GBGT1)
AMJ: 
102565956(GBGT1)
PSS: 
102455930(GBGT1)
CMY: 
102938627(GBGT1)
DRE: 
387303(gbgt1l4)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
Taxonomy
Reference
1  [PMID:4823436]
  Authors
Kijimoto S, Ishibashi T, Makita A.
  Title
Biosynthesis of Forssman hapten from globoside by alpha-N-acetylgalactosaminyltransferase of guinea pig tissues.
  Journal
Biochem. Biophys. Res. Commun. 56 (1974) 177-84.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52037-97-5

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