KEGG   ENZYME: 2.4.1.88Help
Entry
EC 2.4.1.88                 Enzyme                                 

Name
globoside alpha-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase;
Forssman synthase;
globoside acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04182 R05965]
Reaction(KEGG)
R04182 R05965(G);
(other) R11322(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.1.88 created 1976
Pathway
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00722  globoside alpha-N-acetylgalactosaminyltransferase
Genes
HSA: 26301(GBGT1)
PTR: 464823(GBGT1)
PPS: 100978291(GBGT1)
GGO: 101145846(GBGT1)
PON: 100453106(GBGT1)
NLE: 100590023(GBGT1)
MCC: 106993582(GBGT1)
MCF: 102119767(GBGT1)
CSAB: 103239703(GBGT1)
RRO: 104669732(GBGT1)
RBB: 108513510(GBGT1)
CJC: 103795439(GBGT1)
SBQ: 104652637(GBGT1)
MMU: 227671(Gbgt1)
RNO: 499764
CGE: 100771256(Gbgt1)
HGL: 101726516(Gbgt1)
CCAN: 109690998(Gbgt1)
TUP: 102477690(GBGT1)
CFA: 403833(GBGT1)
AML: 100479644(GBGT1)
UMR: 103670247(GBGT1)
ORO: 101386326(GBGT1)
FCA: 101090810(GBGT1)
PTG: 102954717(GBGT1)
AJU: 106985321(GBGT1)
BTA: 618517(GBGT1)
BOM: 102282202(GBGT1)
BIU: 109566575(GBGT1) 109566576
PHD: 102317887(GBGT1)
CHX: 102180325(GBGT1)
OAS: 101112039(GBGT1)
SSC: 110256486(GBGT1)
CDK: 105085187(GBGT1)
BACU: 103008412
LVE: 103086807(GBGT1)
OOR: 105747968(GBGT1)
ECB: 100069388(GBGT1)
EPZ: 103553672(GBGT1)
EAI: 106845361(GBGT1)
MYB: 102239613(GBGT1)
MYD: 102767739(GBGT1)
HAI: 109381005(GBGT1)
RSS: 109439852(GBGT1)
PALE: 102880609(GBGT1)
LAV: 100665584(GBGT1)
TMU: 101349194
MDO: 100017839(GBGT1)
SHR: 100918940(GBGT1)
OAA: 100090987(GBGT1)
GGA: 417163(GBGT1)
MGP: 100540036(GBGT1)
CJO: 107321913(GBGT1)
APLA: 101799653(GBGT1)
ACYG: 106044126(GBGT1)
TGU: 100225394(GBGT1)
GFR: 102040147(GBGT1)
FAB: 101806513(GBGT1)
PHI: 102103511(ABO)
PMAJ: 107212008(GBGT1)
CCW: 104688481(GBGT1)
FPG: 101921547(GBGT1)
FCH: 102050463(GBGT1)
CLV: 102095912(GBGT1)
EGZ: 104129328
AAM: 106483758(GBGT1)
ASN: 102388459(GBGT1)
AMJ: 102565956(GBGT1)
PSS: 102455930(GBGT1)
CMY: 102938627(GBGT1)
CPIC: 101945380(GBGT1)
PVT: 110079644(GBGT1)
GJA: 107124818(GBGT1)
DRE: 387303(gbgt1l4)
AMEX: 103028363
TRU: 101067861
CSEM: 103386423
HCQ: 109522118
CMK: 103178422 103183073(glt6d1)
 » show all
Taxonomy
Reference
1  [PMID:4823436]
  Authors
Kijimoto S, Ishibashi T, Makita A.
  Title
Biosynthesis of Forssman hapten from globoside by alpha-N-acetylgalactosaminyltransferase of guinea pig tissues.
  Journal
Biochem. Biophys. Res. Commun. 56 (1974) 177-84.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.88
IUBMB Enzyme Nomenclature: 2.4.1.88
ExPASy - ENZYME nomenclature database: 2.4.1.88
BRENDA, the Enzyme Database: 2.4.1.88
CAS: 52037-97-5

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