KEGG   ENZYME: 2.4.1.90Help
Entry
EC 2.4.1.90                 Enzyme                                 
Name
N-acetyllactosamine synthase;
UDP-galactose---N-acetylglucosamine beta-D-galactosyltransferase;
uridine diphosphogalactose-acetylglucosamine galactosyltransferase;
beta-1,4-galactosyltransferase;
acetyllactosamine synthetase;
lactosamine synthase;
lactosamine synthetase;
lactose synthetase A protein;
N-acetyllactosamine synthetase;
UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase;
UDP-galactose-acetylglucosamine galactosyltransferase;
UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase;
UDP-galactose-N-acetylglucosamine galactosyltransferase;
beta1-4-galactosyltransferase;
UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase;
beta1-4GalT;
NAL synthetase;
UDP-beta-1,4-galactosyltransferase;
Gal-T;
UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase;
UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase;
beta-N-acetylglucosaminide beta1-4-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-D-glucosamine [CPD:C00140]
Product
UDP [CPD:C00015];
N-acetyllactosamine [CPD:C00611]
Comment
The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.
Orthology
K07966  
beta-1,4-galactosyltransferase 1
K07967  
beta-1,4-galactosyltransferase 2
K07968  
beta-1,4-galactosyltransferase 3
K07969  
beta-1,4-galactosyltransferase 4
Genes
HSA: 
2683(B4GALT1) 8702(B4GALT4) 8703(B4GALT3) 8704(B4GALT2)
PTR: 
100608173(B4GALT4) 100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 
100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3) 100994562(B4GALT4)
GGO: 
101133326(B4GALT2) 101138982(B4GALT1) 101146705(B4GALT4) 101152694(B4GALT3)
PON: 
100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1) 100443591(B4GALT4)
MCC: 
703541(B4GALT1) 704038(B4GALT2) 711983(B4GALT4) 719920(B4GALT3)
MMU: 
14595(B4galt1) 53418(B4galt2) 56375(B4galt4) 57370(B4galt3)
RNO: 
24390(B4galt1) 303923(B4galt4) 313536(B4galt2) 494342(B4galt3)
CFA: 
476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3) 608143(B4GALT4)
AML: 
FCA: 
101084809(B4GALT2) 101089738(B4GALT3) 101100325(B4GALT4) 101100927
BTA: 
100125390(B4GALT2) 281781(B4GALT1) 511328(B4GALT4) 515771(B4GALT3)
SSC: 
100154856 100511655(B4GALT1) 100514465
ECB: 
100065936 100066144 100066149(B4GALT2) 100068209 100071082
MDO: 
100010600 100015888 100028240 100032749 100617718
SHR: 
100917085(B4GALT3) 100918732(B4GALT2) 100929465 100933479(B4GALT4) 100934965
OAA: 
100075607 100092000
GGA: 
396121(B4GALT1) 396122(B4GALT2) 418341(B4GALT4) 418342(B4GALT3)
MGP: 
100543545 100547867 100548019
TGU: 
100219809 100223650(B4GALT1) 100230291 100230857(B4GALT2)
ACS: 
100553459 100553568 100557158 100557558 100558708 100561064
XLA: 
100190782(b4galt2) 379106(MGC52827) 414540 444709(b4galt4) 446718(b4galt3) 496041
XTR: 
100145518(b4galt1.1) 100488464 100492356 448369(b4galt3) 549418(b4galt1.2)
DRE: 
100148828 492760(b4galt4) 550425(b4galt1) 556544(fd56f09) 561756 768123
TRU: 
101061200 101066088 101072068 101075953 101076002
OLA: 
100301598(b4gal-t2) 101159351 101162708 101164915 101171148
CIN: 
100175041
CEL: 
CELE_Y73E7A.7(bre-4)
CBR: 
CBG22165(Cbr-bre-4)
 » show all
Taxonomy
Reference
1  [PMID:99178]
  Authors
Deshmukh DS, Bear WD, Soifer D.
  Title
Isolation and characterization of an enriched Golgi fraction from rat brain.
  Journal
Biochim. Biophys. Acta. 542 (1978) 284-95.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:4631039]
  Authors
Helting T, Erbing B.
  Title
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
  Journal
Biochim. Biophys. Acta. 293 (1973) 94-104.
  Organism
Mus musculus [GN:mmu]
Reference
3  [PMID:812340]
  Authors
Hill RL, Brew K.
  Title
Lactose synthetase.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 43 (1975) 411-90.
Reference
4  [PMID:6201486]
  Authors
Humphreys-Beher MG.
  Title
Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol.
  Journal
J. Biol. Chem. 259 (1984) 5797-802.
  Organism
Rattus norvegicus [GN:rno]
Reference
5  [PMID:4392041]
  Authors
Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S.
  Title
Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction.
  Journal
J. Biol. Chem. 245 (1970) 1090-100.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-94-8
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